WFDC2

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells among other tissues, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

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• {{cite journal | vauthors = Kirchhoff C | title = Molecular characterization of epididymal proteins | journal = Rev. Reprod. | volume = 3 | issue = 2 | pages = 86–95 | year = 1998 | pmid = 9685187 | doi = 10.1530/ror.0.0030086 | doi-access = free }}
• {{cite journal | vauthors = Kirchhoff C, Osterhoff C, Habben I, Ivell R, Kirchloff C | title = Cloning and analysis of mRNAs expressed specifically in the human epididymis | journal = Int. J. Androl. | volume = 13 | issue = 2 | pages = 155–67 | year = 1990 | pmid = 1693137 | doi = 10.1111/j.1365-2605.1990.tb00972.x | doi-access = free }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Bingle L, Singleton V, Bingle CD | title = The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms | journal = Oncogene | volume = 21 | issue = 17 | pages = 2768–73 | year = 2002 | pmid = 11965550 | doi = 10.1038/sj.onc.1205363 | s2cid = 33406517 | doi-access = free }}
• {{cite journal | vauthors = Clauss A, Lilja H, Lundwall A | title = A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein | journal = Biochem. J. | volume = 368 | issue = Pt 1 | pages = 233–42 | year = 2002 | pmid = 12206714 | pmc = 1222987 | doi = 10.1042/BJ20020869 }}
• {{cite journal | vauthors = Hellström I, Raycraft J, Hayden-Ledbetter M, Ledbetter JA, Schummer M, McIntosh M, Drescher C, Urban N, Hellström KE | title = The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma | journal = Cancer Res. | volume = 63 | issue = 13 | pages = 3695–700 | year = 2003 | pmid = 12839961 }}
• {{cite journal | vauthors = Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR, Hecht JL | title = Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas | journal = Cancer Res. | volume = 65 | issue = 6 | pages = 2162–9 | year = 2005 | pmid = 15781627 | doi = 10.1158/0008-5472.CAN-04-3924 | doi-access = free }}
• {{cite journal | vauthors = Clauss A, Lilja H, Lundwall A | title = The evolution of a genetic locus encoding small serine proteinase inhibitors | journal = Biochem. Biophys. Res. Commun. | volume = 333 | issue = 2 | pages = 383–9 | year = 2005 | pmid = 15950183 | pmc = 1939935 | doi = 10.1016/j.bbrc.2005.05.125 }}
• {{cite journal | vauthors = Bingle L, Cross SS, High AS, Wallace WA, Rassl D, Yuan G, Hellstrom I, Campos MA, Bingle CD | title = WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung | journal = Respir. Res. | volume = 7 | issue = 1 | pages = 61 | year = 2006 | pmid = 16600032 | pmc = 1459147 | doi = 10.1186/1465-9921-7-61 | doi-access = free }}
• {{cite journal | vauthors = Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA | title = Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry | journal = J. Proteome Res. | volume = 5 | issue = 6 | pages = 1493–503 | year = 2006 | pmid = 16740002 | doi = 10.1021/pr050492k }}

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Category:Biomarkers