Login
Login

WFDC5

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

WAP four-disulfide core domain protein 5 is a protein that in humans is encoded by the WFDC5 gene.{{cite journal |vauthors=Clauss A, Lilja H, Lundwall A | title = A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein | journal = Biochem J | volume = 368 | issue = Pt 1 | pages = 233–42 |date=Nov 2002 | pmid = 12206714 | pmc = 1222987 | doi = 10.1042/BJ20020869 }}{{cite journal |vauthors=Ranganathan S, Simpson KJ, Shaw DC, Nicholas KR | title = The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling | journal = J Mol Graph Model | volume = 17 | issue = 2 | pages = 106–13, 134–6 |date=Mar 2000 | pmid = 10680116 | doi = 10.1016/S1093-3263(99)00023-6}}{{cite web | title = Entrez Gene: WFDC5 WAP four-disulfide core domain 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=149708}}

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Horikoshi N, Cong J, Kley N, Shenk T |title=Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 864–9 |year= 1999 |pmid= 10441517 |doi= 10.1006/bbrc.1999.1123 }}
  • {{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-style=vanc| author2=Matthews LH | author3=Ashurst J | display-authors=3 | last4=Burton | first4=J. | last5=Gilbert | first5=J. G. R. | last6=Jones | first6=M. | last7=Stavrides | first7=G. | last8=Almeida | first8=J. P. | last9=Babbage | first9=A. K. |bibcode=2001Natur.414..865D | doi-access=free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Clark HF |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |name-list-style=vanc| author2=Gurney AL | author3=Abaya E | display-authors=3 | last4=Baker | first4=K | last5=Baldwin | first5=D | last6=Brush | first6=J | last7=Chen | first7=J | last8=Chow | first8=B | last9=Chui | first9=C }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Nukumi N |title=Analysis of the promoter of mutated human whey acidic protein (WAP) gene |journal=J. Reprod. Dev. |volume=52 |issue= 2 |pages= 315–20 |year= 2006 |pmid= 16462094 |doi=10.1262/jrd.17068 |name-list-style=vanc| author2=Seki M | author3=Iwamori T | display-authors=3 | last4=Yada | first4=Tetsushi | last5=Naito | first5=Kunihiko | last6=Tojo | first6=Hideaki | doi-access=free }}
  • {{cite journal |author2-link=Jeffrey M. Rosen |vauthors=Mukhopadhyay SS, Rosen JM |title=The C-terminal domain of the Nuclear Factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 3 |pages= 770–6 |year= 2007 |pmid= 17511965 |doi= 10.1016/j.bbrc.2007.04.185 | pmc=1942171 }}

{{refend}}

{{gene-20-stub}}