WFIKKN2

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##

• Kazal-type serine protease inhibitor domain

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Szláma G, Kondás K, Trexler M, Patthy L | title = WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity | journal = The FEBS Journal | volume = 277 | issue = 24 | pages = 5040–50 | date = December 2010 | pmid = 21054789 | doi = 10.1111/j.1742-4658.2010.07909.x | s2cid = 45602047 | doi-access = free }}
• {{cite journal | vauthors = Hill JJ, Qiu Y, Hewick RM, Wolfman NM | title = Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains | journal = Molecular Endocrinology | volume = 17 | issue = 6 | pages = 1144–54 | date = June 2003 | pmid = 12595574 | doi = 10.1210/me.2002-0366 | doi-access = free }}
• {{cite journal | vauthors = Kondás K, Szláma G, Trexler M, Patthy L | title = Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 35 | pages = 23677–84 | date = August 2008 | pmid = 18596030 | pmc = 3259755 | doi = 10.1074/jbc.M803025200 | doi-access = free }}
• {{cite journal | vauthors = Nagy A, Trexler M, Patthy L | title = Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein | journal = European Journal of Biochemistry | volume = 270 | issue = 9 | pages = 2101–7 | date = May 2003 | pmid = 12709070 | doi = 10.1046/j.1432-1033.2003.03593.x | doi-access = free }}
• {{cite journal | vauthors = Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET | title = Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women | journal = Journal of Strength and Conditioning Research | volume = 26 | issue = 5 | pages = 1374–82 | date = May 2012 | pmid = 22395277 | doi = 10.1519/JSC.0b013e318251083f | s2cid = 12311653 | doi-access = free }}
• {{cite journal | vauthors = Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K | title = Effects of oral creatine and resistance training on serum myostatin and GASP-1 | journal = Molecular and Cellular Endocrinology | volume = 317 | issue = 1–2 | pages = 25–30 | date = April 2010 | pmid = 20026378 | doi = 10.1016/j.mce.2009.12.019 | s2cid = 25180090 }}
• {{cite journal | vauthors = Trexler M, Bányai L, Patthy L | title = Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules | journal = Biological Chemistry | volume = 383 | issue = 1 | pages = 223–8 | date = January 2002 | pmid = 11928817 | doi = 10.1515/BC.2002.023 | s2cid = 37069938 }}

{{refend}}

{{NLM content}}

Category:Genes

Category:Human proteins

{{gene-17-stub}}