WNT10A

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.

WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.

Mutations in the WNT10A gene are associated with Schöpf–Schulz–Passarge syndrome,{{cite journal |vauthors=Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, Hoffmann M, Ledig S, Sel S, Wieacker P, Röpke A | title = WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes | journal = Am. J. Hum. Genet. | volume = 85 | issue = 1 | pages = 97–105 |date=July 2009 | pmid = 19559398 | pmc = 2706962 | doi = 10.1016/j.ajhg.2009.06.001 }} hypodontia,{{cite journal | vauthors = van den Boogaard MJ, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, Cune M, Ploos van Amstel HK | title = Mutations in WNT10A are present in more than half of isolated hypodontia cases | journal = J. Med. Genet. | volume = 49 | issue = 5 | pages = 327–31 | date = May 2012 | pmid = 22581971 | doi = 10.1136/jmedgenet-2012-100750 | s2cid = 8815004 | url = https://pure.rug.nl/ws/files/6778478/MutationsinWNT10Aarepresentinmore.pdf | access-date = 2019-02-16 | archive-date = 2018-07-23 | archive-url = https://web.archive.org/web/20180723032113/https://pure.rug.nl/ws/files/6778478/MutationsinWNT10Aarepresentinmore.pdf | url-status = dead }} and short anagen hair syndrome.{{Cite journal |last=Cesarato |first=Nicole |last2=Schwieger-Briel |first2=Agnes |last3=Gossmann |first3=Yasmina |last4=Henne |first4=Sabrina K |last5=Hillmann |first5=Kathrin |last6=Frommherz |first6=Leonie H |last7=Wehner |first7=Maria |last8=Xiong |first8=Xing |last9=Thiele |first9=Holger |last10=Oji |first10=Vinzenz |last11=Milani |first11=Donatella |last12=Tantcheva-Poor |first12=Iliana |last13=Giehl |first13=Kathrin |last14=Fölster-Holst |first14=Regina |last15=Teichler |first15=Anne |date=2023-11-16 |title=Short anagen hair syndrome: association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss |url=https://academic.oup.com/bjd/article/189/6/741/7261337 |journal=British Journal of Dermatology |language=en |volume=189 |issue=6 |pages=741–749 |doi=10.1093/bjd/ljad314 |issn=0007-0963|hdl=20.500.11811/11578 |hdl-access=free }}

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{{NLM content}}

{{Wnt signaling pathway}}

{{gene-2-stub}}