WNT11

{{Short description|Protein-coding gene in the species Homo sapiens}}

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.{{cite journal |vauthors=Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S | title = Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung | journal = Gene | volume = 219 | issue = 1–2 | pages = 101–10 |date=Dec 1998 | pmid = 9757009 | doi =10.1016/S0378-1119(98)00393-X }}{{cite web | title = Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7481}}

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene plays roles in the development of bones, kidneys,{{cite journal | last1=Majumdar | first1=Arindam | last2=Vainio | first2=Seppo | last3=Kispert | first3=Andreas | last4=McMahon | first4=Jill | last5=McMahon | first5=Andrew P. | title=Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development | journal=Development | publisher=The Company of Biologists | volume=130 | issue=14 | date=2003-07-15 | issn=1477-9129 | doi=10.1242/dev.00520 | pages=3175–3185| pmid=12783789 | s2cid=25866889 }} and lungs,{{cite journal | last1=Lako | first1=M | last2=Strachan | first2=T | last3=Bullen | first3=P | last4=Wilson | first4=D.I | last5=Robson | first5=S.C | last6=Lindsay | first6=S | title=Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung | journal=Gene | publisher=Elsevier BV | volume=219 | issue=1–2 | year=1998 | issn=0378-1119 | doi=10.1016/s0378-1119(98)00393-x | pages=101–110| pmid=9757009 }} and is associated with early onset osteoporosis. {{cite journal | last1=Caetano da Silva | first1=Caroline | last2=Edouard | first2=Thomas | last3=Fradin | first3=Melanie | last4=Aubert-Mucca | first4=Marion | last5=Ricquebourg | first5=Manon | last6=Raman | first6=Ratish | last7=Salles | first7=Jean Pierre | last8=Charon | first8=Valérie | last9=Guggenbuhl | first9=Pascal | last10=Muller | first10=Marc | last11=Cohen-Solal | first11=Martine | last12=Collet | first12=Corinne | title=WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis | journal=Human Molecular Genetics | publisher=Oxford University Press (OUP) | volume=31 | issue=10 | date=2021-12-07 | issn=0964-6906 | doi=10.1093/hmg/ddab349 | pages=1622–1634| doi-access=free | pmid=34875064 | pmc=9122655 }}

References

{{cite journal |vauthors=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267–75 |year= 1994 |pmid= 8167409 |doi= 10.1091/mbc.4.12.1267| pmc=275763 }}
{{cite journal |vauthors=Kirikoshi H, Sekihara H, Katoh M |title=Molecular cloning and characterization of human WNT11 |journal=Int. J. Mol. Med. |volume=8 |issue= 6 |pages= 651–6 |year= 2002 |pmid= 11712081 |doi= 10.3892/ijmm.8.6.651}}
{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal | author=Ouko L |title=Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26707–15 |year= 2004 |pmid= 15084607 |doi= 10.1074/jbc.M402877200 | pmc=1351009 | author2=Ziegler TR | author3=Gu LH | display-authors=3 | last4=Eisenberg | first4=LM | last5=Yang | first5=VW |doi-access=free }}
{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{cite journal | author=Kim SW |title=Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1212–20 |year= 2005 |pmid= 15543138 |doi= 10.1038/ncb1191 | author2=Park JI | author3=Spring CM | display-authors=3 | last4=Sater | first4=Amy K. | last5=Ji | first5=Hong | last6=Otchere | first6=Abena A. | last7=Daniel | first7=Juliet M. | last8=McCrea | first8=Pierre D. |s2cid=19404686 }}
{{cite journal | author=Koyanagi M |title=Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 16838–42 |year= 2005 |pmid= 15701629 |doi= 10.1074/jbc.M500323200 | author2=Haendeler J | author3=Badorff C | display-authors=3 | last4=Brandes | first4=RP | last5=Hoffmann | first5=J | last6=Pandur | first6=P | last7=Zeiher | first7=AM | last8=Kühl | first8=M | last9=Dimmeler | first9=S | doi-access=free }}
{{cite journal |vauthors=Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA |title=Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus |journal=Dev. Biol. |volume=279 |issue= 1 |pages= 179–92 |year= 2005 |pmid= 15708567 |doi= 10.1016/j.ydbio.2004.12.013 |doi-access= free }}
{{cite journal | author=Otsuki T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 | author2=Ota T | author3=Nishikawa T | display-authors=3 | last4=Hayashi | first4=K | last5=Suzuki | first5=Y | last6=Yamamoto | first6=J | last7=Wakamatsu | first7=A | last8=Kimura | first8=K | last9=Sakamoto | first9=K | doi-access=free }}
{{cite journal |vauthors=Panáková D, Werdich AA, Macrae CA |title=Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. |journal=Nature |volume=466 |issue=8 |pages=874–878 |year= 2010 |pmid=20657579|doi=10.1038/nature09249 |pmc=2921013|bibcode=2010Natur.466..874P }}

WNT11

References

Further reading