Warm-blooded#Defence against fungi

In general, warm-bloodedness refers to three separate categories of thermoregulation.

• Endothermy{{efn|Greek: ἔνδον endon "within" θέρμη thermē "heat"}} is the ability of some creatures to control their body temperatures through internal means such as muscle shivering or increasing their metabolism. The opposite of endothermy is ectothermy.
• Homeothermy{{efn|Greek: ὅμοιος homoios "similar", θέρμη thermē "heat"}} maintains a stable internal body temperature regardless of external influence and temperatures. The stable internal temperature is often higher than the immediate environment. The opposite is poikilothermy. The only known living homeotherms are mammals and birds, as well as one lizard, the Argentine black and white tegu. Some non-avian dinosaurs as well as some extinct reptiles such as ichthyosaurs, pterosaurs, plesiosaurs are believed to have been homeotherms.
• Tachymetabolism{{efn|Greek: ταχύς tachys or tachus "fast, swift", {{lang|grc|μεταβάλλειν}} metaballein "turn quickly"}} maintains a high "resting" metabolism. In essence, tachymetabolic creatures are "on" all the time. Though their resting metabolism is still many times slower than their active metabolism, the difference is often not as large as that seen in bradymetabolic creatures. Tachymetabolic creatures have greater difficulty dealing with a scarcity of food.{{citation needed|date=February 2023}}

A significant proportion of creatures commonly referred to as "warm-blooded," like birds and mammals, exhibit all three of these categories (i.e., they are endothermic, homeothermic, and tachymetabolic).{{Cite journal |last=Osvath |first=Mathias |last2=Němec |first2=Pavel |last3=Brusatte |first3=Stephen L. |last4=Witmer |first4=Lawrence M. |date=2024-11-01 |title=Thought for food: the endothermic brain hypothesis |url=https://www.sciencedirect.com/science/article/pii/S1364661324002018 |journal=Trends in Cognitive Sciences |volume=28 |issue=11 |pages=998–1010 |doi=10.1016/j.tics.2024.08.002 |issn=1364-6613}} However, over the past three decades, investigations in the field of animal thermophysiology have unveiled numerous species within these two groups that do not meet all these criteria. For instance, many bats and small birds become poikilothermic and bradymetabolic during sleep (or, in nocturnal species, during the day). For such creatures, the term heterothermy was introduced.

Further examinations of animals traditionally classified as cold-blooded have revealed that most creatures manifest varying combinations of the three aforementioned terms, along with their counterparts (ectothermy, poikilothermy, and bradymetabolism), thus creating a broad spectrum of body temperature types. Some fish have warm-blooded characteristics, such as the opah. Swordfish and some sharks have circulatory mechanisms that keep their brains and eyes above ambient temperatures and thus increase their ability to detect and react to prey.[http://sciencenow.sciencemag.org/cgi/content/full/2005/110/2 Hot Eyes for Cold Fish – Wong 2005 (110): 2 – ScienceNOW]{{Cite journal| title=Warm brain and eye temperatures in sharks |author1=Block, B.A. |author2=Carey, F.G. |name-list-style=amp | journal=Journal of Comparative Physiology B | volume=156 | issue=2 |date=March 1985 | doi=10.1007/BF00695777 |pmid=3836233 | pages=229–36 |s2cid=33962038 }}{{Cite web| url=http://www.uq.edu.au/news/?article=6503 | title=Warm eyes give deep-sea predators super vision | publisher=University of Queensland | date=11 January 2005 }} Tunas and some sharks have similar mechanisms in their muscles, improving their stamina when swimming at high speed.{{Cite journal | title=Warm-Blooded Fish | author=McFarlane, P. | journal=Monthly Bulletin of the Hamilton and District Aquarium Society | date=January 1999 | url=http://www.aquarticles.com/articles/breeding/McFarlane_Warm_Blooded_Fish.html | access-date=31 May 2008 | archive-url=https://web.archive.org/web/20130515103309/http://www.aquarticles.com/articles/breeding/McFarlane_Warm_Blooded_Fish.html | archive-date=15 May 2013 | url-status=dead }}

{{Main|Thermogenesis}}

Body heat is generated by metabolism.{{Citation |last1=Yousef |first1=Hani |title=Physiology, Thermal Regulation |date=2024 |work=StatPearls |url=http://www.ncbi.nlm.nih.gov/books/NBK499843/ |access-date=2024-02-28 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=29763018 |last2=Ramezanpour Ahangar |first2=Edris |last3=Varacallo |first3=Matthew}} This relates to the chemical reaction in cells that break down glucose into water and carbon dioxide, thereby producing adenosine triphosphate (ATP), a high-energy compound used to power other cellular processes. Muscle contraction is one such metabolic process generating heat energy,{{Cite journal |last1=Periasamy |first1=Muthu |last2=Herrera |first2=Jose Luis |last3=Reis |first3=Felipe C. G. |title=Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism |journal=Diabetes & Metabolism Journal |language=en |publication-date=October 24, 2017 |volume=41 |issue=5 |pages=327–336 |doi=10.4093/dmj.2017.41.5.327 |pmid=29086530 |pmc=5663671 }} and additional heat results from friction as blood circulates through the vascular system in premise to their specialized fat cells which produce heat through uncoupled respiration, contributing to thermoregulation.

All organisms metabolize food and other inputs, but some make better use of the output than others. Like all energy conversions, metabolism is rather inefficient, and around 60% of the available energy is converted to heat rather than to ATP.{{Cite journal |last1=Macherel |first1=David |last2=Haraux |first2=Francis |last3=Guillou |first3=Hervé |last4=Bourgeois |first4=Olivier |date=2021-02-01 |title=The conundrum of hot mitochondria |journal=Biochimica et Biophysica Acta (BBA) - Bioenergetics |volume=1862 |issue=2 |pages=148348 |doi=10.1016/j.bbabio.2020.148348 |pmid=33248118 |issn=0005-2728|doi-access=free |url=https://hal.science/hal-03102332/file/Version%20HAL%20BBABIOv2.pdf }} In most organisms, this heat dissipates into the surroundings. However, endothermic homeotherms (generally referred to as "warm-blooded" animals) not only produce more heat but also possess superior means of retaining and regulating it compared to other animals. They exhibit a higher basal metabolic rate and can further increase their metabolic rate during strenuous activity. They usually have well-developed insulation in order to retain body heat: fur and blubber in the case of mammals and feathers in birds. When this insulation is insufficient to maintain body temperature, they may resort to shivering—rapid muscle contractions that quickly use up ATP, thus stimulating cellular metabolism to replace it and consequently produce more heat. Additionally, almost all eutherian mammals (with the only known exception being swine) have brown adipose tissue whose mitochondria are capable of non-shivering thermogenesis.{{Cite journal |last1=Berg |first1=Frida |last2=Gustafson |first2=Ulla |last3=Andersson |first3=Leif |date=2006-08-18 |title=The Uncoupling Protein 1 Gene (UCP1) Is Disrupted in the Pig Lineage: A Genetic Explanation for Poor Thermoregulation in Piglets |journal=PLOS Genetics |volume=2 |issue=8 |pages=e129 |doi=10.1371/journal.pgen.0020129 |doi-access=free |pmid=16933999 |pmc=1550502 |issn=1553-7404}} This process involves the direct dissipation of the mitochondrial gradient as heat via an uncoupling protein, thereby "uncoupling" the gradient from its usual function of driving ATP production via ATP synthase.{{Cite journal |last1=Cannon |first1=Barbara |last2=Nedergaard |first2=Jan |date=2004-01-01 |title=Brown Adipose Tissue: Function and Physiological Significance |url=https://www.physiology.org/doi/10.1152/physrev.00015.2003 |journal=Physiological Reviews |language=en |volume=84 |issue=1 |pages=277–359 |doi=10.1152/physrev.00015.2003 |pmid=14715917 |issn=0031-9333|url-access=subscription }}

In warm environments, these animals employ evaporative cooling to shed excess heat, either through sweating (some mammals) or by panting (many mammals and all birds)—mechanisms generally absent in poikilotherms.

It has been hypothesized that warm-bloodedness evolved in mammals and birds as a defense against fungal infections. Very few fungi can survive the body temperatures of warm-blooded animals. By comparison, insects, reptiles, and amphibians are plagued by fungal infections.{{cite web|url=https://www.newscientist.com/article/mg21228411.700-killer-fungi-made-us-hotblooded.html#.UeTeVY0wd8E|year=2011|title=Killer Fungi Made us Hotblooded|last=Dunn |first=Rob|work=New Scientist|access-date=27 April 2016}}{{subscription required}}Aviv Bergman, Arturo Casadevall. 2010. [https://mbio.asm.org/content/1/5/e00212-10.full?sid=eb1e9d14-ab01-4d2f-9e5b-623a13ae278f Mammalian Endothermy Optimally Restricts Fungi and Metabolic Costs]. mBio Nov 2010, 1 (5) e00212-10. {{doi|10.1128/mBio.00212-10}}Vincent A. Robert, Arturo Casadevall. 2009. [https://academic.oup.com/jid/article/200/10/1623/881601 Vertebrate Endothermy Restricts Most Fungi as Potential Pathogens]. The Journal of Infectious Diseases, Volume 200, Issue 10, 15 November 2009, Pages 1623–1626. {{doi|10.1086/644642}}Casadevall A (2012) [https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002808 Fungi and the Rise of Mammals]. PLoS Pathog 8(8): e1002808. {{doi|10.1371/journal.ppat.1002808|doi-access=free}} Warm-blooded animals have a defense against pathogens contracted from the environment, since environmental pathogens are not adapted to their higher internal temperature.{{Cite journal|last1=Robert|first1=Vincent A.|last2=Casadevall|first2=Arturo|date=2009-11-15|title=Vertebrate Endothermy Restricts Most Fungi as Potential Pathogens|journal=The Journal of Infectious Diseases|language=en|volume=200|issue=10|pages=1623–1626|doi=10.1086/644642|pmid=19827944|issn=0022-1899|doi-access=free}}

• {{section link|Argentine black and white tegu|Endothermic behavior}}
• Mesotherm
• Thermogenic plant

Footnotes

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Citations

{{Reflist}}

{{Wiktionary}}

• [https://www.earthlife.net/mammals/warm.html What is Warm Blooded??]
• [http://reptilis.net/cold-blood.html The Reptipage: What is cold-blooded?]

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Category:Animal physiology

Category:Thermoregulation

ca:Sang calenta

it:Omeotermia

pt:Homeotermia