Working Formulation

The Working Formulation is a classification of non-Hodgkin lymphomas, first proposed in 1982.{{cite journal |vauthors=MacKenzie RG, Rusthoven JJ |title=Management of localized non-Hodgkin's lymphoma |journal=CMAJ |volume=133 |issue=6 |pages=559–64 |date=1985 |pmid=3896450 |pmc=1346220 }} It has become outdated in light of modern shifts in the understanding and classification of non-Hodgkin lymphomas, leading to the rise of new systems such as the Revised American European Lymphoma classification.{{Cite web |date=2023-12-15 |title=Non-Hodgkin Lymphoma Treatment (PDQ®) - NCI |url=https://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq |access-date=2024-01-22 |website=www.cancer.gov |language=en}} The Working Formulation is still in use, although it is usually applied when analyzing historical data.{{Cite web|date=2023-07-24 |title=Non-Hodgkin Lymphoma Guidelines: Classification, Diagnosis, Staging |url=https://emedicine.medscape.com/article/2500022-overview}}

Low Grade

Malignant lymphoma, small lymphocytic (chronic lymphocytic leukemia)
Malignant lymphoma, follicular, predominantly small cleaved cell
Malignant lymphoma, follicular, mixed (small cleaved and large cell)

Intermediate grade

Malignant lymphoma, follicular, predominantly large cell
Malignant lymphoma, diffuse, small cleaved cell
Malignant lymphoma, diffuse, mixed small and large cell
Malignant lymphoma, diffuse, large cell

High grade

Malignant lymphoma, large cell, immunoblastic
Malignant lymphoma, lymphoblastic
Malignant lymphoma, small noncleaved cells (Burkitt lymphoma)

Miscellaneous

References

Category:Lymphoma