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XPNPEP2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Xaa-Pro aminopeptidase 2 is an enzyme that in humans is encoded by the XPNPEP2 gene.{{cite journal | vauthors = Venema RC, Ju H, Zou R, Venema VJ, Ryan JW | title = Cloning and tissue distribution of human membrane-bound aminopeptidase P | journal = Biochim Biophys Acta | volume = 1354 | issue = 1 | pages = 45–8 |date=Dec 1997 | pmid = 9375790 | doi = 10.1016/s0167-4781(97)00126-7}}{{cite journal | vauthors = Sprinkle TJ, Stone AA, Venema RC, Denslow ND, Caldwell C, Ryan JW | title = Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25 | journal = Genomics | volume = 50 | issue = 1 | pages = 114–6 |date=Apr 1999 | pmid = 9628831 | doi = 10.1006/geno.1998.5302 }}{{cite web | title = Entrez Gene: XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7512}}

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.

References

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Further reading

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  • {{cite journal |vauthors=Vanhoof G, De Meester I, Goossens F, etal |title=Kininase activity in human platelets: cleavage of the Arg1-Pro2 bond of bradykinin by aminopeptidase P |journal=Biochem. Pharmacol. |volume=44 |issue= 3 |pages= 479–87 |year= 1992 |pmid= 1510698 |doi=10.1016/0006-2952(92)90439-P }}
  • {{cite journal | vauthors=Cottrell GS, Hyde RJ, Hooper NM, Turner AJ |title=The cloning and functional expression of human pancreatic aminopeptidase P |journal=Biochem. Soc. Trans. |volume=26 |issue= 3 |pages= S248 |year= 1998 |doi=10.1042/bst026s248 |pmid= 9765967 }}
  • {{cite journal |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |bibcode=2000PNAS...97.3491D |doi-access=free }}
  • {{cite journal | vauthors=Prueitt RL, Ross JL, Zinn AR |title=Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1–2 |pages= 44–50 |year= 2000 |pmid= 10894934 |doi=10.1159/000015560 |s2cid=46232057 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Fu GK, Wang JT, Yang J, etal |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011 }}
  • {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |bibcode=2005Natur.434..325R }}
  • {{cite journal |vauthors=Molinaro G, Duan QL, Chagnon M, etal |title=Kinin-dependent hypersensitivity reactions in hemodialysis: metabolic and genetic factors |journal=Kidney Int. |volume=70 |issue= 10 |pages= 1823–31 |year= 2007 |pmid= 17003818 |doi= 10.1038/sj.ki.5001873 |doi-access= free }}

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