XPOT
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Exportin-T is a protein that in humans is encoded by the XPOT gene.{{cite journal | vauthors = Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D | title = Identification of a tRNA-specific nuclear export receptor | journal = Mol Cell | volume = 1 | issue = 3 | pages = 359–69 |date=Jul 1998 | pmid = 9660920 | doi =10.1016/S1097-2765(00)80036-2 | doi-access = free }}{{cite journal | vauthors = Arts GJ, Fornerod M, Mattaj IW | title = Identification of a nuclear export receptor for tRNA | journal = Curr Biol | volume = 8 | issue = 6 | pages = 305–14 |date=May 1998 | pmid = 9512417 | doi =10.1016/S0960-9822(98)70130-7 | s2cid = 17803674 | doi-access = free }}{{cite web | title = Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11260}}
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Arts GJ, Kuersten S, Romby P, etal |title=The role of exportin-t in selective nuclear export of mature tRNAs. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7430–41 |year= 1999 |pmid= 9857198 |doi= 10.1093/emboj/17.24.7430 | pmc=1171087 }}
- {{cite journal |vauthors=Kruse C, Willkomm DK, Grünweller A, etal |title=Export and transport of tRNA are coupled to a multi-protein complex. |journal=Biochem. J. |volume=346 |issue= 1|pages= 107–15 |year= 2000 |pmid= 10657246 |doi=10.1042/0264-6021:3460107 | pmc=1220829 }}
- {{cite journal |vauthors=Kutay U, Hartmann E, Treichel N, etal |title=Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40163–8 |year= 2001 |pmid= 11024021 |doi= 10.1074/jbc.M006242200 |doi-access= free |hdl= 11858/00-001M-0000-0015-3D4E-B |hdl-access= free }}
- {{cite journal |vauthors=Kuersten S, Arts GJ, Walther TC, etal |title=Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5708–20 |year= 2002 |pmid= 12138183 |doi=10.1128/MCB.22.16.5708-5720.2002 | pmc=133969 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Suzuki T, Koyama Y, Hayakawa S, etal |title=1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. |journal=Biomed. Res. |volume=27 |issue= 2 |pages= 89–92 |year= 2006 |pmid= 16707848 |doi=10.2220/biomedres.27.89 |doi-access=free }}
- {{cite journal | vauthors=Li S, Sprinzl M |title=Interaction of immobilized human exportin-t with calf liver tRNA. |journal=RNA Biol |volume=3 |issue= 4 |pages= 145–9 |year= 2007 |pmid= 17224653 |doi= 10.4161/rna.3.4.3679|doi-access=free }}
{{refend}}
{{gene-12-stub}}