Xin Lu
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Xin Lu {{post-nominals|country=GBR|FRS}} is a Professor of Cancer Biology and Director of the Ludwig Institute for Cancer Research at the University of Oxford.{{Cite web|url=https://www.ndm.ox.ac.uk/principal-investigators/researcher/xin-lu|title=Professor Xin Lu - Nuffield Department of Medicine|website=www.ndm.ox.ac.uk|access-date=2018-03-12}} She is known for her discovery of and research on the ASPP family of proteins.{{Cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Xin-Lu-0008826|title=Professor Xin Lu {{!}} The Academy of Medical Sciences|website=acmedsci.ac.uk|access-date=2018-03-12}}{{Cite journal|date=Winter 2011|title=Focus on Xin Lu|url=http://www.embo.org/documents/news/encounters/EMBO_encounters_issue20.pdf|journal=EMBO Encounters|issue=20|pages=5}}
Education
Xin Lu completed her undergraduate education in Biochemistry at Sichuan University in 1982 and her master's degree in Cell and Molecular Biology at the Cancer Institute, Peking Union Medical College & Chinese Academy of Medical Sciences in 1985. She moved to University College London (UCL){{Cite web|url=https://www.ludwigcancerresearch.org/scientist/xin-lu/|title=Xin Lu|website=Ludwig Institute}} to complete her PhD studies supervised by Birgit Lane,{{Cite web|url=https://www.exeter.ac.uk/livingsystems/team/honorary/lane/|title=Professor Birgitte Lane, FRSE, FMedSci{{!}}{{!}} University of Exeter|website=www.exeter.ac.uk|access-date=2019-10-02}} and published her thesis A study of intermediate filament formation using retrovirus-mediated gene transfer in 1991.{{Cite thesis|publisher=University of London, University College London|date=February 1991|degree=PhD|title=A study of intermediate filament formation using retrovirus-mediated gene transfer|language=en|id = {{ProQuest|2009333448}}}}
Research and career
In 1993, after a short postdoc with David Lane at Dundee University, she joined the Ludwig Institute for Cancer Research (LICR), which was based at St Mary's Hospital, Imperial College London and set up her own research group. In 2004 Lu was appointed Director of Research at Ludwig Institute for Cancer Research London Branch, and Professor of Cancer Biology at University College London. In 2007 she moved the institute to Oxford.{{Cite web|url=https://www.diversityprojects.ox.ac.uk/wis/meet/30|title=Xin Lu — Diversity Projects|website=www.diversityprojects.ox.ac.uk|language=en|access-date=2018-03-12}}{{Cite web|url=http://www.magd.ox.ac.uk/member-of-staff/xin-lu/|title=Professor Xin Lu {{!}} Magdalen College Oxford|website=www.magd.ox.ac.uk|language=en|access-date=2018-03-12}}
Honours and awards
- Fellow of the Royal Society (2020){{cite web|url=https://royalsociety.org/people/Xin-Lu-25368/|title=Xin Lu|publisher=Royal Society|access-date= 19 September 2020}}
- Fellow of the Academy of Medical Sciences (2013)
- Member of the Academia Europaea (2022)
- Member of the European Molecular Biology Organization (2011){{Cite web|url=https://www.ludwigcancerresearch.org/news/director-licr-oxford-branch-professor-xin-lu-phd-frcpath-elected-european-molecular-biology|title=DIRECTOR OF LICR OXFORD BRANCH, PROFESSOR XIN LU, PHD FRCPATH, ELECTED TO EUROPEAN MOLECULAR BIOLOGY ORGANIZATION|date=Oct 21, 2011|website=Ludwig Institute}}
- Fellow of the Royal Society of Biology (2011–2022)
- Fellow of the Royal College of Pathologists (2007–2022)
Notable works
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{{Cite journal|last=Lu|first=X|title=Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?|journal=Cell|volume=75|issue=4|pages=765–778|doi=10.1016/0092-8674(93)90496-d|pmid=8242748|year=1993|doi-access=free}}
{{Cite journal|last1=Hsieh|first1=Jung-Kuang|last2=Chan|first2=Florence S.G|last3=O’Connor|first3=Daniel J|last4=Mittnacht|first4=Sibylle|last5=Zhong|first5=Shan|last6=Lu|first6=Xin|title=RB Regulates the Stability and the Apoptotic Function of p53 via MDM2|journal=Molecular Cell|volume=3|issue=2|pages=181–193|doi=10.1016/s1097-2765(00)80309-3|year=1999|pmid=10078201|doi-access=free}}
{{Cite journal|last1=Samuels-Lev|first1=Yardena|author-link=Yardena Samuels|last2=O'Connor|first2=Daniel J.|last3=Bergamaschi|first3=Daniele|last4=Trigiante|first4=Giuseppe|last5=Hsieh|first5=Jung-Kuang|last6=Zhong|first6=Shan|last7=Campargue|first7=Isabelle|last8=Naumovski|first8=Louie|last9=Crook|first9=Tim|title=ASPP Proteins Specifically Stimulate the Apoptotic Function of p53|journal=Molecular Cell|volume=8|issue=4|pages=781–794|doi=10.1016/s1097-2765(01)00367-7|pmid=11684014|year=2001|doi-access=free}}
{{Cite journal|last1=Lu|first1=Min|last2=Zak|first2=Jaroslav|last3=Chen|first3=Shuo|last4=Sanchez-Pulido|first4=Luis|last5=Severson|first5=David T.|last6=Endicott|first6=Jane|last7=Ponting|first7=Chris P.|last8=Schofield|first8=Christopher J.|last9=Lu|first9=Xin|title=A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway|journal=Cell|volume=157|issue=5|pages=1130–1145|doi=10.1016/j.cell.2014.05.006|year=2014|pmid=24855949|doi-access=free}}
{{Cite journal|last1=Bergamaschi|first1=Daniele|last2=Samuels|first2=Yardena|last3=O'Neil|first3=Nigel J.|last4=Trigiante|first4=Giuseppe|last5=Crook|first5=Tim|last6=Hsieh|first6=Jung-Kuang|last7=O'Connor|first7=Daniel J.|last8=Zhong|first8=Shan|last9=Campargue|first9=Isabelle|date=2003|title=iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human|journal=Nature Genetics|language=En|volume=33|issue=2|pages=162–167|doi=10.1038/ng1070|issn=1546-1718|pmid=12524540|s2cid=22841392}}
{{Cite journal|last1=Notari|first1=Mario|last2=Hu|first2=Ying|last3=Sutendra|first3=Gopinath|last4=Dedeić|first4=Zinaida|last5=Lu|first5=Min|last6=Dupays|first6=Laurent|last7=Yavari|first7=Arash|last8=Carr|first8=Carolyn A.|last9=Zhong|first9=Shan|date=2015-03-03|title=iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death|journal=Proceedings of the National Academy of Sciences|volume=112|issue=9|pages=E973–E981|doi=10.1073/pnas.1408111112|pmid=25691752|pmc=4352828|bibcode=2015PNAS..112E.973N|doi-access=free}}
{{Cite journal|last1=Wang|first1=Yihua|last2=Bu|first2=Fangfang|last3=Royer|first3=Christophe|last4=Serres|first4=Sébastien|last5=Larkin|first5=James R.|last6=Soto|first6=Manuel Sarmiento|last7=Sibson|first7=Nicola R.|last8=Salter|first8=Victoria|last9=Fritzsche|first9=Florian|date=2014|title=ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1|journal=Nature Cell Biology|language=En|volume=16|issue=11|pages=1092–1104|doi=10.1038/ncb3050|pmid=25344754|s2cid=20735236|issn=1476-4679}}
{{Cite journal|last1=Turnquist|first1=Casmir|last2=Wang|first2=Yihua|last3=Severson|first3=David T.|last4=Zhong|first4=Shan|last5=Sun|first5=Bin|last6=Ma|first6=Jingyi|last7=Constantinescu|first7=Stefan N.|last8=Ansorge|first8=Olaf|last9=Stolp|first9=Helen B.|date=2014-07-08|title=STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression|journal=Proceedings of the National Academy of Sciences|volume=111|issue=27|pages=9834–9839|doi=10.1073/pnas.1407898111|pmid=24958857|pmc=4103354|bibcode=2014PNAS..111.9834T|doi-access=free}}
{{Cite journal|last1=Lu|first1=Min|last2=Breyssens|first2=Hilde|last3=Salter|first3=Victoria|last4=Zhong|first4=Shan|last5=Hu|first5=Ying|last6=Baer|first6=Caroline|last7=Ratnayaka|first7=Indrika|last8=Sullivan|first8=Alex|last9=Brown|first9=Nicholas R.|title=Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP|journal=Cancer Cell|volume=23|issue=5|pages=618–633|doi=10.1016/j.ccr.2013.03.013|pmid=23623661|year=2013|doi-access=free}}
{{Cite journal|last1=Wang|first1=Yihua|last2=Wang|first2=Xiao Dan|last3=Lapi|first3=Eleonora|last4=Sullivan|first4=Alexandra|last5=Jia|first5=Wei|last6=He|first6=You-Wen|last7=Ratnayaka|first7=Indrika|last8=Zhong|first8=Shan|last9=Goldin|first9=Robert D.|date=2012-08-14|title=Autophagic activity dictates the cellular response to oncogenic RAS|journal=Proceedings of the National Academy of Sciences|volume=109|issue=33|pages=13325–13330|doi=10.1073/pnas.1120193109|pmid=22847423|pmc=3421174|bibcode=2012PNAS..10913325W|doi-access=free}}
{{Cite journal|last1=Notari|first1=Mario|last2=Hu|first2=Ying|last3=Koch|first3=Sofia|last4=Lu|first4=Min|last5=Ratnayaka|first5=Indrika|last6=Zhong|first6=Shan|last7=Baer|first7=Caroline|last8=Pagotto|first8=Anna|last9=Goldin|first9=Robert|date=2011-10-04|title=Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification|journal=Proceedings of the National Academy of Sciences|volume=108|issue=40|pages=16645–16650|doi=10.1073/pnas.1102292108|pmid=21930934|pmc=3189025|bibcode=2011PNAS..10816645N|doi-access=free}}
{{Cite journal|last1=Slee|first1=Elizabeth A.|last2=Benassi|first2=Barbara|last3=Goldin|first3=Robert|last4=Zhong|first4=Shan|last5=Ratnayaka|first5=Indrika|last6=Blandino|first6=Giovanni|last7=Lu|first7=Xin|date=2010-11-09|title=Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo|journal=Proceedings of the National Academy of Sciences|volume=107|issue=45|pages=19479–19484|doi=10.1073/pnas.1005165107|pmid=20962274|pmc=2984175|bibcode=2010PNAS..10719479S|doi-access=free}}
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References
{{FRS 2020}}
{{Portal bar|Biography}}
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{{DEFAULTSORT:Lu, Xin}}
Category:Year of birth missing (living people)
Category:Sichuan University alumni
Category:Peking Union Medical College alumni
Category:Alumni of Imperial College London