YTHDC1

YTHDC1 has been shown to interact with:

• Abl gene,
• C-src tyrosine kinase,{{cite journal | vauthors = Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S | title = The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation | journal = Hum. Mol. Genet. | volume = 13 | issue = 15 | pages = 1535–49 | date = Aug 2004 | pmid = 15175272 | doi = 10.1093/hmg/ddh167 | doi-access = }}
• Emerin,{{cite journal | vauthors = Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE | title = Emerin interacts in vitro with the splicing-associated factor, YT521-B | journal = Eur. J. Biochem. | volume = 270 | issue = 11 | pages = 2459–66 | date = Jun 2003 | pmid = 12755701 | doi = 10.1046/j.1432-1033.2003.03617.x| doi-access = free }}
• KHDRBS1. and
• Metadherin{{Cite journal|last1=Luxton|first1=Hayley J.|last2=Simpson|first2=Benjamin S.|last3=Mills|first3=Ian G.|last4=Brindle|first4=Nicola R.|last5=Ahmed|first5=Zeba|last6=Stavrinides|first6=Vasilis|last7=Heavey|first7=Susan|last8=Stamm|first8=Stefan|last9=Whitaker|first9=Hayley C.|date=2019-08-23|title=The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing|journal=Cancers|volume=11|issue=9|page=1233|doi=10.3390/cancers11091233|issn=2072-6694|pmc=6770463|pmid=31450747|doi-access=free}}

Alternative splicing is altered in a number of diseases and is particularly relevant to cancer.

YTHDC1 has been shown to splice mRNA transcripts which have oncological importance, regulating tumour functions such as hypoxia associated vascular endothelial growth factor (VEGF), DNA damage associated breast cancer 1 (BRCA1) and hormonal growth driver; the progesterone receptor (PGR).{{Cite journal|last1=Hirschfeld|first1=Marc|last2=Zhang|first2=Bo|last3=Jaeger|first3=Markus|last4=Stamm|first4=Stefan|last5=Erbes|first5=Thalia|last6=Mayer|first6=Sebastian|last7=Tong|first7=Xiaowen|last8=Stickeler|first8=Elmar|date=November 2014|title=Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression|journal=Molecular Carcinogenesis|volume=53|issue=11|pages=883–892|doi=10.1002/mc.22045|issn=1098-2744|pmid=23765422|s2cid=35669580}}{{Cite journal|last1=Zhang|first1=Bo|last2=Shao|first2=Xiaowen|last3=Zhou|first3=Jianhong|last4=Qiu|first4=Jin|last5=Wu|first5=Yi|last6=Cheng|first6=Jiajing|date=2015-08-21|title=YT521 promotes metastases of endometrial cancer by differential splicing of vascular endothelial growth factor A|journal= Tumor Biology|volume=37|issue=12|pages=15543–15549|doi=10.1007/s13277-015-3908-y|issn=1423-0380|pmid=26289848|s2cid=11257001}}

In prostate cancer, YTHDC1 has also been shown to interact with the protein metadherin, encoded by the oncogene MTDH acting to influence alternative splicing of tumour-related genes such as CD44.{{Cite journal|last1=Yoo|first1=Byoung Kwon|last2=Emdad|first2=Luni|last3=Su|first3=Zao-zhong|last4=Villanueva|first4=Augusto|last5=Chiang|first5=Derek Y.|last6=Mukhopadhyay|first6=Nitai D.|last7=Mills|first7=Alan Scott|last8=Waxman|first8=Samuel|last9=Fisher|first9=Robert A.|last10=Llovet|first10=Josep M.|last11=Fisher|first11=Paul B.|date=March 2009|title=Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression|journal=The Journal of Clinical Investigation|volume=119|issue=3|pages=465–477|doi=10.1172/JCI36460|issn=1558-8238|pmc=2648696|pmid=19221438}}

N⁶-Methyladenosine

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T | title = Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation. | journal = Brain Res. Mol. Brain Res. | volume = 53 | issue = 1–2 | pages = 33–40 | year = 1998 | pmid = 9473574 | doi = 10.1016/S0169-328X(97)00262-3 }}
• {{cite journal | vauthors = Nayler O, Hartmann AM, Stamm S | title = The ER repeat protein YT521-B localizes to a novel subnuclear compartment. | journal = J. Cell Biol. | volume = 150 | issue = 5 | pages = 949–62 | year = 2000 | pmid = 10973987 | pmc = 2175241 | doi = 10.1083/jcb.150.5.949 }}
• {{cite journal | vauthors = Stoss O, Olbrich M, Hartmann AM, Konig H, Memmott J, Andreadis A, Stamm S | title = The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. | journal = J. Biol. Chem. | volume = 276 | issue = 12 | pages = 8665–73 | year = 2001 | pmid = 11118435 | doi = 10.1074/jbc.M006851200 | doi-access = free }}
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• {{cite journal | vauthors = Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE | title = Emerin interacts in vitro with the splicing-associated factor, YT521-B. | journal = Eur. J. Biochem. | volume = 270 | issue = 11 | pages = 2459–66 | year = 2003 | pmid = 12755701 | doi = 10.1046/j.1432-1033.2003.03617.x | doi-access = free }}
• {{cite journal | vauthors = Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S | title = The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. | journal = Hum. Mol. Genet. | volume = 13 | issue = 15 | pages = 1535–49 | year = 2005 | pmid = 15175272 | doi = 10.1093/hmg/ddh167 | doi-access = }}
• {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
• {{cite journal | vauthors = Stoss O, Novoyatleva T, Gencheva M, Olbrich M, Benderska N, Stamm S | title = p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1. | journal = Mol. Cell. Neurosci. | volume = 27 | issue = 1 | pages = 8–21 | year = 2005 | pmid = 15345239 | doi = 10.1016/j.mcn.2004.04.011 | s2cid = 31339890 }}
• {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
• {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
• {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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