Ying Ge
{{short description|Chinese-American biologist}}
{{Infobox scientist
| name = Ying Ge
| alma_mater = Cornell University
University of Peking
| workplaces = University of Wisconsin-Madison
Wyeth
| thesis_title = Top down characterization of proteins by electron capture dissociation and blackbody infrared radiative dissociation mass spectrometry
| thesis_url = http://www.worldcat.org/oclc/52791635
| thesis_year = 2002
}}
Ying Ge is a Chinese-American chemist who is a Professor of Cell and Regenerative Biology at the University of Wisconsin–Madison. Her research considers the molecular mechanisms that underpin cardiac disease. She has previously served on the board of directors of the American Society for Mass Spectrometry. In 2020 Ge was named on the Analytical Scientist Power List.
Early life and education
Ge was born in China. She attended Peking University for her undergraduate studies, where she studied chemistry.{{Cite web|title=yge {{!}} Department of Chemistry|url=https://www2.chem.wisc.edu/users/yge|access-date=2020-10-18|website=www2.chem.wisc.edu|language=en}} After graduating in 1997 Ge moved to the United States, where she joined Cornell University as a doctoral student. Here she started to work on mass spectrometry, using electron-capture dissociation to study proteins.{{Cite thesis|title=Top down characterization of proteins by electron capture dissociation and blackbody infrared radiative dissociation mass spectrometry|url=https://www.worldcat.org/oclc/52791635|date=2002|language=English|first=Ying|last=Ge|oclc=52791635}} She worked under the supervision of Tadhg Begley and Fred McLafferty. After completing her doctorate, Ge worked as a research scientist at Wyeth.{{citation needed|date=October 2020}}
Research and career
Ge joined the University of Wisconsin–Madison as an assistant scientist, where she oversaw the mass spectrometry programme. She became an associate professor in 2015, and full professor in 2019.{{Cite web|title=Ying Ge|url=https://hupo2020.org/speaker/ying-ge/|access-date=2021-10-31|website=HUPO Connect 2020|language=en-US}}
Ge develops high-resolution mass spectrometry proteomics to better understand cardiac disease. To image the very large proteins of human heart tissue, Ge combines fourier-transform ion cyclotron resonance (FT–ICR) mass spectrometry with electron-capture dissociation.{{Cite web|title=Biemann Medal|url=https://www.asms.org/about-asms-awards/biemann-medal|access-date=2020-10-18|website=www.asms.org}} She has worked to create a top-down disease proteomic platform that allows for the separation, detection and characterisation of the biomarkers of heart damage.
Nanoproteomics, a technique developed by Ge and co-workers, makes use of nanoparticles and high resolution mass spectrometry to capture and characterise cardiac troponins, including troponin I.{{Cite web|date=2020-08-07|title=New Nanoparticle Technology Reveals Common Marker of Heart Disease|url=https://www.azonano.com/news.aspx?newsID=37473|access-date=2020-10-19|website=AZoNano.com|language=en}}{{Cite web|title=Nanoparticle system captures heart-disease biomarker from blood for in-depth analysis|url=https://phys.org/news/2020-08-nanoparticle-captures-heart-disease-biomarker-blood.html|access-date=2020-10-19|website=phys.org|language=en}} Being able to test for and characterise troponin I would help with the early detection and diagnosis of heart disease.{{Cite web|date=2020-08-07|title=Biomarker for Heart Disease Captured by Novel Nanoparticle Technology|url=https://www.genengnews.com/news/biomarker-for-heart-disease-captured-by-novel-nanoparticle-technology/|access-date=2020-10-19|website=GEN - Genetic Engineering and Biotechnology News|language=en-US}} The peptide-functionalised superparamagnetic nanoparticles are combined with top-down mass spectrometry to identify the molecular fingerprints of troponins. Rather than just detecting cardiac troponins, which is possible using ELISA-based antibody testing, this higher level of characterisation will allow Ge to identify various forms of modified troponins, allowing a personalised understanding of cardiac disease.
Ge served on the board of the Top-Down Proteomics Consortium,{{Cite web|title=Board of Directors – Consortium for Top-Down Proteomics|url=https://www.topdownproteomics.org/about-the-consortium/board-of-directors/|access-date=2021-10-31|language=en-US}} on the editorial board of the Journal of Muscle Research and Cell Motility,{{Cite web|title=Journal of Muscle Research and Cell Motility|url=https://www.springer.com/journal/10974/editors|access-date=2021-10-31|website=Springer|language=en}} as treasurer for the American Society for Mass Spectrometry (2016-2018).{{Cite journal|last1=Brodbelt|first1=Jenny|last2=Li|first2=Lingjun|date=2021-08-23|title=Editorial: Focus on Top-Down Proteomics: Technology Advances and Biomedical Applications, Honoring Dr. Ying Ge, Recipient of the 2020 ASMS Biemann Medal|journal=Journal of the American Society for Mass Spectrometry|volume=33 |issue=9 |pages=1586–1589 |doi=10.1021/jasms.1c00209|pmid=34423982 |s2cid=237268712 |issn=1044-0305|doi-access=free}}
[https://scholar.google.com/citations?user=Ymgpd5QAAAAJ&hl=en&oi=sra Ying Ge] publications indexed by Google Scholar.
Awards and honours
- 2016 Georges Guiochon Faculty Fellowship{{Cite web|title=Ying Ge Receives Georges Guiochon Faculty Fellowship at HPLC 2016|url=https://www.chromatographyonline.com/view/ying-ge-receives-georges-guiochon-faculty-fellowship-hplc-2016|access-date=2020-10-18|website=Chromatography Online|date=22 June 2016 }}
- 2018 H. I. Romnes Faculty Fellowship{{Cite web|last=|first=|date=2018-03-15|title=Dr. Ying Ge awarded H.I. Romnes Faculty Fellowship|url=https://molpharm.wisc.edu/2018/03/15/dr-ying-ge-awarded-h-i-romnes-faculty-fellowship/|archive-url=|archive-date=|access-date=2020-10-18|website=Molecular and Cellular Pharmacology Training Program|language=en-US}}
- 2019 Analytical Scientist Power List{{Cite web |title=The Power List 2019 |url=https://theanalyticalscientist.com/powerlist/2019 |access-date=2022-12-27 |website=The Analytical Scientist |language=en}}
- 2020 American Society for Mass Spectrometry Biemann Medal
- 2020 Analytical Scientist Power List{{Cite web|title=Ying Ge|url=https://theanalyticalscientist.com/power-list/2020/north-america/ying-ge|access-date=2020-10-18|website=The Analytical Scientist|language=en}}
- 2021 Human Proteome Organization (HUPO) Clinical and Translational Proteomics Award{{Cite web|title=HUPO - 2021 HUPO Awards|url=https://hupo.org/2021-HUPO-AWARDS|access-date=2021-10-31|website=hupo.org}}
- 2021 Analytical Scientist Power List{{Cite web |title=The Power List 2021 |url=https://theanalyticalscientist.com/power-list/2021 |access-date=2022-12-27 |website=The Analytical Scientist |language=en}}
- 2024 Analytical Scientist Power List, ranked #8 in "Human Health Heroes" field{{Cite web |date=2024-08-17 |title=The Power List 2024 |url=https://theanalyticalscientist.com/power-list/2024 |access-date=2024-08-24 |website=The Analytical Scientist |language=en}}
Selected publications
- {{Cite journal|last1=Smith|first1=Lloyd M|last2=Kelleher|first2=Neil L|date=2013-02-27|title=Proteoform: a single term describing protein complexity|url= |journal=Nature Methods|volume=10|issue=3|pages=186–187|doi=10.1038/nmeth.2369|pmid=23443629|pmc=4114032|issn=1548-7091}}
- {{Cite journal|last1=Ge|first1=Ying|last2=Lawhorn|first2=Brian G.|last3=ElNaggar|first3=Mariam|last4=Strauss|first4=Erick|last5=Park|first5=Joo-Heon|last6=Begley|first6=Tadhg P.|last7=McLafferty|first7=Fred W.|date=2002-01-01|title=Top Down Characterization of Larger Proteins (45 kDa) by Electron Capture Dissociation Mass Spectrometry|url=https://doi.org/10.1021/ja011335z|journal=Journal of the American Chemical Society|volume=124|issue=4|pages=672–678|doi=10.1021/ja011335z|pmid=11804498|bibcode=2002JAChS.124..672G |issn=0002-7863|url-access=subscription}}
- {{Cite journal|last1=Horn|first1=David M.|last2=Ge|first2=Ying|last3=McLafferty|first3=Fred W.|date=2000-10-01|title=Activated Ion Electron Capture Dissociation for Mass Spectral Sequencing of Larger (42 kDa) Proteins|url=https://doi.org/10.1021/ac000494i|journal=Analytical Chemistry|volume=72|issue=20|pages=4778–4784|doi=10.1021/ac000494i|pmid=11055690|issn=0003-2700|url-access=subscription}}
- {{Cite journal|last1=Sze|first1=Siu Kwan|last2=Ge|first2=Ying|last3=Oh|first3=HanBin|last4=McLafferty|first4=Fred W.|date=2002-02-19|title=Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue|journal=Proceedings of the National Academy of Sciences|language=en|volume=99|issue=4|pages=1774–1779|doi=10.1073/pnas.251691898|issn=0027-8424|pmid=11842225|pmc=122269|doi-access=free}}
References
{{reflist}}{{Biemann Medal Recipients}}{{Authority control}}
{{DEFAULTSORT:Ge, Ying}}
Category:American people of Chinese descent
Category:University of Wisconsin–Madison faculty
Category:Peking University alumni
Category:Cornell University alumni
Category:Year of birth missing (living people)
Category:Cardiovascular researchers