YoungSoo Kim

Kim completed his B.A. degree in biochemistry from New York University in 2001, with Professor Young-Tae Chang as an undergraduate research advisor. He then studied bioorganic chemistry under the supervision of Professor Kim D. Janda at Scripps Research and obtained his Ph.D. degree{{Cite news|url=https://www.scripps.edu/newsandviews/e_20020909/class.html|title=TSRI Kellogg School's Entering Class in 2002}} in chemistry in 2006.

In 2006, Kim joined Korea Institute of Science and Technology (KIST) as a research scientist. In 2010, after his military service duty, he became a principal investigator of Brain Science Institute at KIST and associate professor of biological chemistry at Korea University of Science and Technology (UST). In 2017, he moved to Yonsei University as an assistant professor of bio-convergence (ISED) and pharmacy. In 2020, he was promoted to an associate professor of pharmacy.

In addition to Department of Pharmacy, Kim is affiliated in three other departments of Yonsei; Integrated Science and Engineering Division (ISED), of Underwood International College (UIC), Graduate Program of Integrative Biotechnology and Translational Medicine (IBTM), and Graduate Program of Industrial Pharmaceutical Sciences. Kim is an adjunct professor of POSTECH.{{Cite web|url=http://www.businesskorea.co.kr/news/articleView.html?idxno=30544|title=POSTECH and Yonsei University to Create Blockchain Campus Together|date=2019-04-03|website=BusinessKorea|language=ko|access-date=2020-03-11}}

Kim is an editorial board member (neurology section) of Scientific Reports,{{Cite web|url=https://www.nature.com/srep/about/editorial-board|title=Editorial Advisory Panel and Editorial Board|website=Scientific Reports}} academic editor of PLOS ONE,{{Cite web|url=https://journals.plos.org/plosone/static/editorial-board|title=PLOS ONE Editorial Board – Academic Editors}} executive editor of [https://www.en-journal.org/ Experimental Neurobiology].{{Cite web |title=Experimental Neurobiology |url=https://www.en-journal.org/content/about/editorial_board.html |access-date=2022-10-28 |website=www.en-journal.org |language=en}}

His laboratory is located at Yonsei University International Campus{{Cite web|url=https://uic.yonsei.ac.kr/main/academic.asp?mid=m03_01_01&act=view&uid=931&keyword=|title=Underwood International College – Faculty Page|website=Yonsei University|language=EN|access-date=2017-05-13}}{{Cite web|url=http://pharmacy.yonsei.ac.kr/index.php|title=College of Pharmacy|website=Yonsei University|access-date=2017-05-13}} in Songdo International Business District. Kim's work focuses on pathology, therapeutics, and diagnostics of Alzheimer's disease by using Chemical Biology as a research tool. A significant effort of the Kim laboratory in recent years has been to identify small molecules that control protein misfolding and cognitive impairments of Alzheimer's disease. Such research achievements in taurine derivatives reversing Alzheimer pathology{{Cite journal|date=2015|title=EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques|journal=Nature Communications|volume=6|page=8997|doi=10.1038/ncomms9997 | last1 = Yun Kim | first1 = Hye|doi-access=free|pmid=26646366|pmc=4686862|bibcode=2015NatCo...6.8997K }}{{Cite journal|date=2014|title=Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease|journal=Scientific Reports|volume=4|doi=10.1038/srep07467 | pmc=4264000 | last1 = Yun Kim | first1 = Hye | last2 = Kim | first2 = Hyunjin V. | last3 = Yoon | first3 = Jin H. | last4 = Ram Kang | first4 = Bo | last5 = Min Cho | first5 = Soo | last6 = Lee | first6 = Sejin | last7 = Yoon Kim | first7 = Ji | last8 = Won Kim | first8 = Joo | last9 = Cho | first9 = Yakdol | last10 = Woo | first10 = Jiwan | last11 = Kim | first11 = YoungSoo|page=7467 |pmid=25502280 |bibcode=2014NatSR...4E7467K | doi-access = free }} and Alzheimer blood tests detecting plasma amyloid-beta{{Cite journal|date=2014|title=Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model|journal=Scientific Reports|volume=4|doi=10.1038/srep06777 |pmc=4209448 | last1 = Min Cho | first1 = Soo | last2 = Vincent Kim | first2 = Hyunjin | last3 = Lee | first3 = Sejin | last4 = Yun Kim | first4 = Hye | last5 = Kim | first5 = Woong | last6 = Song Kim | first6 = Tae | last7 = Jin Kim | first7 = Dong | last8 = Kim | first8 = YoungSoo|page=6777 |pmid=25345439 |bibcode=2014NatSR...4E6777C | doi-access = free }}{{Cite journal|date=2015|title=Age-dependent inverse correlations in CSF and plasma amyloid-β(1–42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice|journal=Scientific Reports|volume=6|doi=10.1038/srep20185 | last1 = Min Cho | first1 = Soo | last2 = Lee | first2 = Sejin | last3 = Yang | first3 = Seung-Hoon | last4 = Yun Kim | first4 = Hye | last5 = Jisoo Lee | first5 = Michael | last6 = Vincent Kim | first6 = Hyunjin | last7 = Kim | first7 = Jiyoon | last8 = Baek | first8 = Seungyeop | last9 = Yun | first9 = Jin | last10 = Kim | first10 = Dohee | last11 = Kyung Kim | first11 = Yun | last12 = Cho | first12 = Yakdol | last13 = Woo | first13 = Jiwan | last14 = Song Kim | first14 = Tae | last15 = Kim | first15 = YoungSoo|page=20185 |pmid=26830653 |pmc=4735736 | doi-access = free }}{{Cite journal|date=2015|title=Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model|journal=Scientific Reports|volume=5|doi=10.1038/srep15703| pmc=4621607 | last1 = Yang | first1 = Seung-Hoon | last2 = Kim | first2 = Jiyoon | last3 = Jisoo Lee | first3 = Michael | last4 = Kim | first4 = YoungSoo|page=15703 |pmid=26503550 |bibcode=2015NatSR...515703Y | doi-access = free }}{{Cite news|url=http://www.businesskorea.co.kr/english/news/sciencetech/13756-blood-testing-dementia-early-dementia-diagnosis-based-blood-test-become|title=Early Dementia Diagnosis Based on Blood Test to Become Possible in 2019|date=2016|work=Business Korea}}{{Cite journal|year=2019|title=Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system|journal=Science Advances|language=en|volume=5|issue=4|pages=eaav1388|doi=10.1126/sciadv.aav1388|pmid=31001580|pmc=6469948|last1=Kim|first1=Youngsoo|last2=Yoo|first2=Yong Kyoung|last3=Kim|first3=Hye Yun|last4=Roh|first4=Jee Hoon|last5=Kim|first5=Jinsik|last6=Baek|first6=Seungyeop|last7=Lee|first7=Jinny Claire|last8=Kim|first8=Hye Jin|last9=Chae|first9=Myung-Sic|last10=Jeong|first10=Dahye|last11=Park|first11=Dongsung|last12=Lee|first12=Sejin|last13=Jang|first13=Hochung|last14=Kim|first14=Kyeonghwan|last15=Lee|first15=Jeong Hoon|last16=Byun|first16=Byung Hyun|last17=Park|first17=Su Yeon|last18=Ha|first18=Jeong Ho|last19=Lee|first19=Kyo Chul|last20=Cho|first20=Won Woo|last21=Kim|first21=Jae-Seung|last22=Koh|first22=Jae-Young|last23=Lim|first23=Sang Moo|last24=Hwang|first24=Kyo Seon|bibcode=2019SciA....5.1388K }} contributed to rank Korea Institute of Science and Technology #6 among The World's Most Innovative Research Institutions, selected by Reuters, in 2016{{Cite web|url=https://www.reuters.com/innovation/most-innovative-institutions/profile/?uid=6|title=Top 25 Global Innovators – #6 Korea Institute of Science & Technology in 2016|website=Reuters}} and 2017.{{Cite web|url=https://www.reuters.com/innovation/most-innovative-institutions-2017/profile?uid=6|title=Top 25 Global Innovators – #6 Korea Institute of Science & Technology in 2017|website=Reuters}} His recent review article{{Cite journal|last1=Lee|first1=Jinny Claire|last2=Kim|first2=Soo Jung|last3=Hong|first3=Seungpyo|last4=Kim|first4=YoungSoo|date=2019|title=Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers|journal=Experimental & Molecular Medicine|language=en|volume=51|issue=5|pages=1–10 |doi=10.1038/s12276-019-0250-2|pmid=31073121 |pmc=6509326 |issn=2092-6413|doi-access=free}} about fluid biomarkers of Alzheimer's disease published in Experimental & Molecular Medicine was selected in Springer Nature 2019 Highlights.{{Cite web|url=https://www.springernature.com/gp/researchers/campaigns/highlights/cell-biology-and-biochemistry/more-articles|title=Springer Nature 2019 Research Highlights|website=www.springernature.com|access-date=2020-03-11}} Examples of such molecules discovered include:

• EPPS, a small molecule disaggregating amyloid-beta oligomers and plaques{{Cite news|url=https://www.bbc.com/news/health-35039306|title=Molecule clears Alzheimer's plaques in mice|date=2015|work=BBC}}{{Cite news|url=https://www.theguardian.com/science/2015/dec/08/taurine-like-chemical-restores-cognitive-function-in-mice-with-alzheimers|title=Taurine-like chemical restores cognitive function in mice with Alzheimer's|date=2015|work=The Guardian}}{{Cite journal|date=2016|title=Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil|journal=Scientific Reports|volume=6|doi=10.1038/srep34165 | last1 = Yun Kim | first1 = Hye | last2 = Vincent Kim | first2 = Hyunjin | last3 = Lee | first3 = Dongkeun K. | last4 = Yang | first4 = Seung-Hoon | last5 = Kim | first5 = YoungSoo|page=34165 |pmid=27796293 |pmc=5086916 |bibcode=2016NatSR...634165K | doi-access = free }}
• Taurine, a food supplement recovering learning and memory
• Necrostatin-1, an anti-necroptotic molecule regulating both amyloid-beta misfolding and tau hyperphosphorylation{{Cite journal|date=2017|title=Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mic|url=http://embomolmed.embopress.org/content/early/2016/11/16/emmm.201606566|journal=EMBO Molecular Medicine}}
• CLASS (Comparing Levels of Aβ by Self-Standard), a blood test method to diagnose Alzheimer's disease
• Drug repositioning for chemical-driven clearance of amyloid plaques{{Cite journal |last1=Lee |first1=Jinny Claire |last2=Kim |first2=Hye Yun |last3=Lee |first3=Sejin |last4=Shin |first4=Jisu |last5=Kim |first5=Hyunjin Vincent |last6=Kim |first6=Kyeonghwan |last7=Baek |first7=Seungyeop |last8=Lee |first8=Donghee |last9=Jeon |first9=Hanna |last10=Kim |first10=DaWon |last11=Yang |first11=Seung‐Hoon |last12=Han |first12=Gyoonhee |last13=Park |first13=Keunwan |last14=Choi |first14=Jaeho |last15=Park |first15=Jinwoo |date=2020-07-06 |title=Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory‐Impairing Anti‐Parallel Aβ Dimers |url=https://onlinelibrary.wiley.com/doi/10.1002/anie.202002574 |journal=Angewandte Chemie International Edition |language=en |volume=59 |issue=28 |pages=11491–11500 |doi=10.1002/anie.202002574 |pmid=32233096 |s2cid=214748857 |issn=1433-7851|url-access=subscription }}
• Chemical-driven outflow of dissociated amyloid burden from brain to blood{{Cite journal |last1=Lee |first1=Donghee |last2=Kim |first2=Hyunjin Vincent |last3=Kim |first3=Hye Yun |last4=Kim |first4=YoungSoo |date=2022 |title=Chemical‐Driven Outflow of Dissociated Amyloid Burden from Brain to Blood |journal=Advanced Science |language=en |volume=9 |issue=12 |pages=2104542 |doi=10.1002/advs.202104542 |issn=2198-3844 |pmc=9036038 |pmid=35106958}}

He is a co-founder and CSO of [http://www.amyloidsolution.com Amyloid Solution].

• [http://chembio.yonsei.ac.kr YoungSoo Kim Group Website]
• [https://scholar.google.co.kr/citations?user=YGiMJ5cAAAAJ&hl=ko&authuser=2 Google Scholar]

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Category:1978 births

Category:Academic staff of Yonsei University

Category:Living people

Category:New York University alumni

Category:Scripps Research alumni

Category:South Korean chemists

Category:South Korean biochemists