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ZAK

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.{{cite web | title = Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51776}}

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

{{cite journal|title=Cloning and Expression of ZAK, a Mixed Lineage Kinase-like Protein Containing a Leucine-Zipper and a Sterile-Alpha Motif |journal=Biochemical and Biophysical Research Communications |volume=274 |issue=3 |date=11 August 2000 |pages=811–816 |doi=10.1006/bbrc.2000.3236|pmid=10924358 |last1=Liu |first1=Te-Chung |last2=Huang |first2=Chang-Jen |last3=Chu |first3=Yu-Chuan |last4=Wei |first4=Chih-Chang |last5=Chou |first5=Chun-Chieh |last6=Chou |first6=Ming-Yung |last7=Chou |first7=Chen-Kung |last8=Yang |first8=Jaw-Ji }}

Interactions

ZAK has been shown to interact with ZNF33A.{{cite journal |doi=10.1016/S0006-291X(02)02980-7 |last=Yang |first=Jaw-Ji |date=Jan 2003 |title=A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue=1 |pages=71–7 | issn = 0006-291X| pmid = 12535642 }}

References

{{reflist}}

  • {{cite journal |title=Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK |journal=The Chinese Journal of Physiology |volume=61 |issue=1 |pages=25–34 |date=28 February 2018 |doi=10.4077/CJP.2018.BAG528|last1=Lee |first1=Jin-Sun |pmid=29374956 }}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Liu TC, Huang CJ, Chu YC, etal |title=Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 3 |pages= 811–6 |year= 2000 |pmid= 10924358 |doi= 10.1006/bbrc.2000.3236 }}
  • {{cite journal |vauthors=Gotoh I, Adachi M, Nishida E |title=Identification and characterization of a novel MAP kinase kinase kinase, MLTK. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4276–86 |year= 2001 |pmid= 11042189 |doi= 10.1074/jbc.M008595200 |doi-access= free }}
  • {{cite journal |vauthors=Bloem LJ, Pickard TR, Acton S, etal |title=Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. |journal=J. Mol. Cell. Cardiol. |volume=33 |issue= 9 |pages= 1739–50 |year= 2002 |pmid= 11549352 |doi= 10.1006/jmcc.2001.1437 }}
  • {{cite journal |vauthors=Gross EA, Callow MG, Waldbaum L, etal |title=MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13873–82 |year= 2002 |pmid= 11836244 |doi= 10.1074/jbc.M111994200 |doi-access= free }}
  • {{cite journal | author=Yang JJ |title=Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 1 |pages= 105–10 |year= 2002 |pmid= 12220515 |doi=10.1016/S0006-291X(02)02123-X }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Yang JJ |title=A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 71–7 |year= 2003 |pmid= 12535642 |doi=10.1016/S0006-291X(02)02980-7 }}
  • {{cite journal |vauthors=Takahashi M, Gotoh Y, Isagawa T, etal |title=Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 181–7 |year= 2004 |pmid= 12761180 |doi=10.1093/jb/mvg022 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Cho YY, Bode AM, Mizuno H, etal |title=A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. |journal=Cancer Res. |volume=64 |issue= 11 |pages= 3855–64 |year= 2004 |pmid= 15172994 |doi= 10.1158/0008-5472.CAN-04-0201 |doi-access= free }}
  • {{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |doi-access=free }}
  • {{cite journal |vauthors=Tosti E, Waldbaum L, Warshaw G, etal |title=The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. |journal=J. Biol. Chem. |volume=279 |issue= 46 |pages= 47652–60 |year= 2005 |pmid= 15342622 |doi= 10.1074/jbc.M409961200 |doi-access=free }}
  • {{cite journal |vauthors=Huang CY, Kuo WW, Chueh PJ, etal |title=Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 424–31 |year= 2004 |pmid= 15465036 |doi= 10.1016/j.bbrc.2004.09.067 }}
  • {{cite journal |vauthors=Huang CY, Chueh PJ, Tseng CT, etal |title=ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 3 |pages= 973–80 |year= 2004 |pmid= 15485649 |doi= 10.1016/j.bbrc.2004.09.156 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Choi HS, Choi BY, Cho YY, etal |title=Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13545–53 |year= 2005 |pmid= 15684425 |doi= 10.1074/jbc.M410521200 |doi-access= free }}
  • {{cite journal |vauthors=Wang X, Mader MM, Toth JE, etal |title=Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 19298–305 |year= 2005 |pmid= 15737997 |doi= 10.1074/jbc.M413059200 |doi-access= free }}
  • {{cite journal |vauthors=Benzinger A, Muster N, Koch HB, etal |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |doi-access= free }}
  • {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access=free }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}

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{{Serine/threonine-specific protein kinases}}

{{Enzymes}}

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Category:EC 2.7.11

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