ZEB2-AS1
{{Infobox_gene}}
ZEB2-AS1 (ZEB2 antisense RNA 1) is a long non-coding RNA, which is overlapping and antisense to the ZEB2 gene.{{cite journal |vauthors=Nelles L, Van de Putte T, van Grunsven L, Huylebroeck D, Verschueren K |title=Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1 |journal=Genomics |volume=82 |issue=4 |pages=460–469 |date=October 2003 |pmid=13679026 |doi= 10.1016/S0888-7543(03)00169-1}}{{cite journal |vauthors=Beltran M, Puig I, Peña C, etal |title=A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition |journal=Genes Dev. |volume=22 |issue=6 |pages=756–769 |date=March 2008 |pmid=18347095 |pmc=2275429 |doi=10.1101/gad.455708 }} It overlaps the 5′ splice site of an intron within the 5′UTR of the ZEB2 gene. This intron contains an internal ribosome entry site (IRES), which is necessary for ZEB2 expression. ZEB2-AS1 prevents the splicing of this intron, and therefore activates ZEB2 expression.
See also
References
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Further reading
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- {{cite journal |vauthors=Cano A, Nieto MA |title=Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition |journal=Trends Cell Biol. |volume=18 |issue=8 |pages=357–359 |date=August 2008 |pmid=18585040 |doi=10.1016/j.tcb.2008.05.005 }}
- {{cite journal |vauthors=Kumar PA, Kotlyarevska K, Dejkhmaron P, etal |title=Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy |journal=J. Biol. Chem. |volume=285 |issue=41 |pages=31148–31156 |date=October 2010 |pmid=20682777 |doi=10.1074/jbc.M110.132332 |pmc=2951188|doi-access=free }}
- {{cite journal |author=Mattick JS |title=The genetic signatures of noncoding RNAs |journal=PLOS Genet. |volume=5 |issue=4 |pages=e1000459 |date=April 2009 |pmid=19390609 |pmc=2667263 |doi=10.1371/journal.pgen.1000459 |doi-access=free }}
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External links
- {{Rfam|id=RF01984|name=ZEB2-AS1-1}}
- {{Rfam|id=RF01985|name=ZEB2-AS1-2}}
- {{Rfam|id=RF01986|name=ZEB2-AS1-3}}
- {{Rfam|id=RF01987|name=ZEB2-AS1-4}}
{{Navbox
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| title = Gallery of ZEB2-AS1 conserved RNA secondary structure images
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| Image:ZEB2_AS1_1_secondary_structure.jpg|ZEB2_AS1_1: Secondary structure taken from the [http://rfam.org Rfam] database. Family [http://rfam.org/family/RF01984 RF01984]
| Image:ZEB2_AS1_2_secondary_structure.jpg|ZEB2_AS1_2: Secondary structure taken from the [http://rfam.org Rfam] database. Family [http://rfam.org/family/RF01985 RF01985]
| Image:ZEB2_AS1_3_secondary_structure.jpg|ZEB2_AS1_3: Secondary structure taken from the [http://rfam.org Rfam] database. Family [http://rfam.org/family/RF01986 RF01986]
| Image:ZEB2_AS1_4_secondary_structure.jpg|ZEB2_AS1_4: Secondary structure taken from the [http://rfam.org Rfam] database. Family [http://rfam.org/family/RF01987 RF01987]
}}
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