ZFYVE1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ZFYVE1 gene.{{cite journal | vauthors = Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW | title = Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library | journal = Gene | volume = 255 | issue = 2 | pages = 195–203 |date=Nov 2000 | pmid = 11024279 | doi =10.1016/S0378-1119(00)00303-6 | url = https://zenodo.org/record/1260045 }}{{cite journal | vauthors = Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM | title = Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi | journal = Biochem J | volume = 355 | issue = Pt 1 | pages = 113–21 |date=Mar 2001 | pmid = 11256955 | pmc = 1221718 | doi =10.1042/0264-6021:3550113 }}{{cite web | title = Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53349}}
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution.
Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.
References
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Further reading
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- {{cite journal |vauthors=Nagase T, Kikuno R, Nakayama M, etal |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi= 10.1093/dnares/7.4.271|doi-access=free }}
- {{cite journal |vauthors=Ridley SH, Ktistakis N, Davidson K, etal |title=FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. |journal=J. Cell Sci. |volume=114 |issue= Pt 22 |pages= 3991–4000 |year= 2002 |doi=10.1242/jcs.114.22.3991 |pmid= 11739631 |url=https://espace.library.uq.edu.au/view/UQ:186570/UQ186570_OA.pdf }}
- {{cite journal |vauthors=Krugmann S, Anderson KE, Ridley SH, etal |title=Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. |journal=Mol. Cell |volume=9 |issue= 1 |pages= 95–108 |year= 2002 |pmid= 11804589 |doi=10.1016/S1097-2765(02)00434-3 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Heilig R, Eckenberg R, Petit JL, etal |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 |bibcode=2003Natur.421..601H |doi-access= free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Wan D, Gong Y, Qin W, etal |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 | pmc=524842 |bibcode=2004PNAS..10115724W |doi-access=free }}
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