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ZNF239

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Zinc finger protein 239 is a protein that in humans is encoded by the ZNF239 gene.{{cite journal | vauthors = Arranz V, Kress M, Ernoult-Lange M | title = Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19 | journal = Mammalian Genome | volume = 7 | issue = 1 | pages = 77–8 | date = Jan 1996 | pmid = 8903737 | doi = 10.1007/s003359900020 | s2cid = 36851320 }}{{cite journal | vauthors = Ernoult-Lange M, Arranz V, Le Coniat M, Berger R, Kress M | title = Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins | journal = Journal of Molecular Evolution | volume = 41 | issue = 6 | pages = 784–94 | date = Dec 1995 | pmid = 8587123 | doi = 10.1007/bf00173158 | bibcode = 1995JMolE..41..784E | s2cid = 22955858 }}{{cite web | title = Entrez Gene: ZNF239 zinc finger protein 239| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8187}}

Function

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures.{{cite journal | vauthors = Arranz V, Harper F, Florentin Y, Puvion E, Kress M, Ernoult-Lange M | title = Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains | journal = Molecular and Cellular Biology | volume = 17 | issue = 4 | pages = 2116–26 | date = Apr 1997 | pmid = 9121460 | pmc = 232059 | doi = 10.1128/mcb.17.4.2116 }}

Interactions

ZNF239 has been shown to interact with LMNA.{{cite journal | vauthors = Dreuillet C, Tillit J, Kress M, Ernoult-Lange M | title = In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C | journal = Nucleic Acids Research | volume = 30 | issue = 21 | pages = 4634–42 | date = Nov 2002 | pmid = 12409453 | pmc = 135794 | doi = 10.1093/nar/gkf587 }}

References

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Further reading

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  • {{cite journal | vauthors = Dreuillet C, Tillit J, Kress M, Ernoult-Lange M | title = In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C | journal = Nucleic Acids Research | volume = 30 | issue = 21 | pages = 4634–42 | date = Nov 2002 | pmid = 12409453 | pmc = 135794 | doi = 10.1093/nar/gkf587 }}

\* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}

  • {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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External links

  • {{MeshName|ZNF239+protein,+human}}

{{NLM content}}

{{Transcription factors|g2}}

Category:Transcription factors

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