ZNF41
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.{{cite journal | vauthors = Franze A, Archidiacono N, Rocchi M, Marino M, Grimaldi G | title = Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome | journal = Genomics | volume = 9 | issue = 4 | pages = 728–36 |date=Jul 1991 | pmid = 2037297 | doi =10.1016/0888-7543(91)90367-N }}{{cite web | title = Entrez Gene: ZNF41 zinc finger protein 41| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7592}}
This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known.
References
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Further reading
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- {{cite journal |vauthors=Rosati M, Marino M, Franzè A, etal |title=Members of the zinc finger protein gene family sharing a conserved N-terminal module |journal=Nucleic Acids Res. |volume=19 |issue= 20 |pages= 5661–7 |year= 1991 |pmid= 1945843 |doi=10.1093/nar/19.20.5661 | pmc=328972 }}
- {{cite journal |vauthors=Knight JC, Grimaldi G, Thiesen HJ, etal |title=Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1 |journal=Genomics |volume=21 |issue= 1 |pages= 180–7 |year= 1994 |pmid= 8088786 |doi= 10.1006/geno.1994.1240 }}
- {{cite journal | vauthors=Rosati M, Franzé A, Matarazzo MR, Grimaldi G |title=Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41 |journal=Cytogenet. Cell Genet. |volume=85 |issue= 3–4 |pages= 291–6 |year= 1999 |pmid= 10449920 |doi=10.1159/000015315 |s2cid=26777065 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Shoichet SA, Hoffmann K, Menzel C, etal |title=Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation |journal=Am. J. Hum. Genet. |volume=73 |issue= 6 |pages= 1341–54 |year= 2004 |pmid= 14628291 |doi=10.1086/380309 | pmc=1180399 }}
- {{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |bibcode=2005Natur.434..325R }}
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External links
- {{MeshName|ZNF41+protein,+human}}
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{{Transcription factors|g2}}
Category:Transcription factors
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