ZNF74
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.{{cite journal | vauthors = Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA | title = Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2) | journal = Genomics | volume = 13 | issue = 3 | pages = 641–8 | date = August 1992 | pmid = 1639391 | doi = 10.1016/0888-7543(92)90135-F }}{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = December 1999 | pmid = 10591208 | doi = 10.1038/990031 | bibcode = 1999Natur.402..489D | doi-access = free }}{{cite web | title = Entrez Gene: ZNF74 zinc finger protein 74| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7625}} Schizophrenia susceptibility has been associated with a mutation in this protein.{{cite journal|last=Takase|first=K.|author2=T. Ohtsuki |author3=O. Migita |author4=M. Toru |author5=T. Inada |author6=K. Yamakawa-Kobayashi |author7=T. Arinami |title=Association of ZNF74 gene genotypes with age-at-onset of schizophrenia|journal=Schizophrenia Research|date=1 December 2001|volume=52|issue=3|pages=161–165|doi=10.1016/s0920-9964(00)00191-2|pmid=11705709|s2cid=42865851}}
Interactions
ZNF74 has been shown to interact with POLR2A.{{cite journal | vauthors = Grondin B, Côté F, Bazinet M, Vincent M, Aubry M | title = Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit | journal = J. Biol. Chem. | volume = 272 | issue = 44 | pages = 27877–85 | date = October 1997 | pmid = 9346935 | doi = 10.1074/jbc.272.44.27877 | doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Aubry M, Demczuk S, Desmaze C, Aikem M, Aurias A, Julien JP, Rouleau GA | title = Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome | journal = Hum. Mol. Genet. | volume = 2 | issue = 10 | pages = 1583–7 | year = 1994 | pmid = 8268910 | doi = 10.1093/hmg/2.10.1583 }}
- {{cite journal | vauthors = Grondin B, Bazinet M, Aubry M | title = The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix | journal = J. Biol. Chem. | volume = 271 | issue = 26 | pages = 15458–67 | year = 1996 | pmid = 8663113 | doi = 10.1074/jbc.271.26.15458 | doi-access = free }}
- {{cite journal | vauthors = Grondin B, Côté F, Bazinet M, Vincent M, Aubry M | title = Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit | journal = J. Biol. Chem. | volume = 272 | issue = 44 | pages = 27877–85 | year = 1997 | pmid = 9346935 | doi = 10.1074/jbc.272.44.27877 | doi-access = free }}
- {{cite journal | vauthors = Ravassard P, Côté F, Grondin B, Bazinet M, Mallet J, Aubry M | title = ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia | journal = Genomics | volume = 62 | issue = 1 | pages = 82–5 | year = 2000 | pmid = 10585771 | doi = 10.1006/geno.1999.5982 }}
- {{cite journal | vauthors = Côté F, Boisvert FM, Grondin B, Bazinet M, Goodyer CG, Bazett-Jones DP, Aubry M | title = Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning | journal = DNA Cell Biol. | volume = 20 | issue = 3 | pages = 159–73 | year = 2001 | pmid = 11313019 | doi = 10.1089/104454901300069004 }}
- {{cite journal | vauthors = Takase K, Ohtsuki T, Migita O, Toru M, Inada T, Yamakawa-Kobayashi K, Arinami T | title = Association of ZNF74 gene genotypes with age-at-onset of schizophrenia | journal = Schizophrenia Research | volume = 52 | issue = 3 | pages = 161–5 | year = 2001 | pmid = 11705709 | doi = 10.1016/S0920-9964(00)00191-2 | s2cid = 42865851 }}
- {{cite journal | vauthors = Germain-Desprez D, Bazinet M, Bouvier M, Aubry M | title = Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 22367–73 | year = 2003 | pmid = 12684500 | doi = 10.1074/jbc.M302234200 | doi-access = free }}
- {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biol. | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 | doi-access = free }}
- {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
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External links
- {{MeshName|ZNF74+protein,+human}}
{{Transcription factors|g2}}
{{NLM content}}
Category:Transcription factors
{{gene-22-stub}}