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Zinc transporter ZIP1

{{Short description|Protein found in humans}}

{{Infobox_gene}}

Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.{{cite journal | vauthors = Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J | title = Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex | journal = Genomics | volume = 62 | issue = 2 | pages = 272–80 |date=Feb 2000 | pmid = 10610721 | doi = 10.1006/geno.1999.5993 }}{{cite journal | vauthors = Gaither LA, Eide DJ | title = Functional expression of the human hZIP2 zinc transporter | journal = J Biol Chem | volume = 275 | issue = 8 | pages = 5560–4 |date=Mar 2000 | pmid = 10681536 | doi =10.1074/jbc.275.8.5560 | doi-access = free }}{{cite web | title = Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27173}}

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.{{cite journal | vauthors = Costello LC, Franklin RB | title = The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots | journal = Mol. Cancer | volume = 5 | pages = 17 | year = 2006 | pmid = 16700911 | pmc = 1481516 | doi = 10.1186/1476-4598-5-17 | doi-access = free }}

See also

References

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Further reading

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  • {{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY, etal |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703 | pmc=310876 }}
  • {{cite journal | vauthors=Gaither LA, Eide DJ |title=The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22258–64 |year= 2001 |pmid= 11301334 |doi= 10.1074/jbc.M101772200 |doi-access= free }}
  • {{cite journal |vauthors=Milon B, Dhermy D, Pountney D, etal |title=Differential subcellular localization of hZip1 in adherent and non-adherent cells. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 241–6 |year= 2001 |pmid= 11696349 |doi=10.1016/S0014-5793(01)02950-7 |s2cid=19962909 |doi-access= }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Franklin RB, Ma J, Zou J, etal |title=Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. |journal=J. Inorg. Biochem. |volume=96 |issue= 2–3 |pages= 435–42 |year= 2003 |pmid= 12888280 |doi=10.1016/S0162-0134(03)00249-6 |pmc=4465841 }}
  • {{cite journal |vauthors=Dufner-Beattie J, Langmade SJ, Wang F, etal |title=Structure, function, and regulation of a subfamily of mouse zinc transporter genes |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50142–50 |year= 2004 |pmid= 14525987 |doi= 10.1074/jbc.M304163200 |doi-access= free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Franklin RB, Feng P, Milon B, etal |title=hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer |journal=Mol. Cancer |volume=4 |pages= 32 |year= 2006 |pmid= 16153295 |doi= 10.1186/1476-4598-4-32 | pmc=1243239 |doi-access=free }}
  • {{cite journal |vauthors=Tang Z, Sahu SN, Khadeer MA, etal |title=Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells |journal=Bone |volume=38 |issue= 2 |pages= 181–98 |year= 2006 |pmid= 16203195 |doi= 10.1016/j.bone.2005.08.010 }}
  • {{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |doi-access= free }}
  • {{cite journal | vauthors=Huang L, Kirschke CP |title=A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein |journal=FEBS J. |volume=274 |issue= 15 |pages= 3986–97 |year= 2007 |pmid= 17635580 |doi= 10.1111/j.1742-4658.2007.05933.x |s2cid=21792127 |doi-access=free }}

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{{Membrane transport proteins}}

Category:Solute carrier family

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