Anna Marie Pyle
{{short description|American academic}}
{{Infobox scientist
| name = Anna Marie Pyle
| alma_mater = Princeton University, Columbia University
| workplaces = Yale University, University of Colorado
}}
Anna Marie Pyle is an American academic who is a Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Chemistry at Yale University. and an Investigator for Howard Hughes Medical Institute.{{Cite web|url=https://mcdb.yale.edu/people/anna-marie-pyle|title=Anna Marie Pyle, Ph.D. {{!}} Molecular, Cellular and Developmental Biology|website=mcdb.yale.edu|access-date=2019-03-01}} Pyle is the president of the RNA Society,{{Cite web|url=https://www.rnasociety.org/|title=RNA Society|access-date=2019-03-01}} the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section{{Cite web|url=https://public.csr.nih.gov/StudySections/DBIB/BCMB/MSFA|title=MSFA {{!}} NIH Center for Scientific Review|website=public.csr.nih.gov|access-date=2019-03-01}} at the National Institutes of Health.
Early life and education
Pyle grew up in Albuquerque, New Mexico, and it was there that she first became interested in science.{{Cite web|url=http://www.asbmb.org/asbmbtoday/201510/2016Meeting/Pyle/|title=2016 Annual Meeting Plenary Lecturer: Pyle|website=www.asbmb.org|access-date=2019-03-01}} But it wasn't until after earning her bachelor's degree from Princeton University that she committed to a career in chemistry. In 1990, she graduated from Columbia University with a Ph.D. in chemistry. Pyle went on to postdoc at the University of Colorado until in 1992 she established a research group at Columbia University Medical Center in the Department of Biochemistry and Molecular Biophysics. In 2002, she moved to Yale University.
Research
Pyle joined Yale University in 2002. She researches the architectural features of large RNA molecules and RNA remodeling enzymes using experimental biochemistry and crystallography. such as self-splicing introns and other noncoding RNAs. She has focused her research to understand how large RNAs assemble into specific, stable tertiary structures, and also how ATP-dependent enzymes in the cell recognize and remodel RNA. Specifically, she was successful in crystallizing and solving the structure of a group IIC intron from the bacterium Oceanobacillus iheyensis{{Cite journal|last1=Toor|first1=Navtej|last2=Keating|first2=Kevin S.|last3=Fedorova|first3=Olga|last4=Rajashankar|first4=Kanagalaghatta|last5=Wang|first5=Jimin|last6=Pyle|first6=Anna Marie|date=January 2010|title=Tertiary architecture of the Oceanobacillus iheyensis group II intron|journal=RNA|volume=16|issue=1|pages=57–69|doi=10.1261/rna.1844010|issn=1355-8382|pmc=2802037|pmid=19952115}} and moves through the stages of splicing.{{Cite journal|last1=Pyle|first1=A. M.|last2=Marcia|first2=M.|date=2012|title=Visualizing Group II Intron Catalysis through the Stages of Splicing.|url=http://www.rcsb.org/pdb/explore/litView.do?structureId=4E8K|journal=Cell|volume=151|issue=3|pages=497–507|doi=10.2210/pdb4e8k/pdb|pmid=23101623|pmc=3628766|access-date=2019-03-01|archive-date=2019-03-27|archive-url=https://web.archive.org/web/20190327101157/http://www.rcsb.org/pdb/explore/litView.do?structureId=4E8K|url-status=dead}} Pyle's research may be helpful in drug development as RNA's tertiary structure could provide insight into druggable biomolecules.{{Cite web|url=https://cen.acs.org/pharmaceuticals/drug-discovery/Targeting-RNAs-tertiary-structure/96/i43|title=Targeting RNA's tertiary structure|website=Chemical & Engineering News|access-date=2019-03-01}}{{Cite journal|last1=Pyle|first1=Anna Marie|last2=Zandt|first2=Michael C. Van|last3=Lin Yuan|last4=Adams|first4=Rebecca L.|last5=Jagdmann|first5=G. Erik|last6=Fedorova|first6=Olga|date=December 2018|title=Small molecules that target group II introns are potent antifungal agents|journal=Nature Chemical Biology|volume=14|issue=12|pages=1073–1078|doi=10.1038/s41589-018-0142-0|pmid=30323219|pmc=6239893|issn=1552-4469}}
Selected awards and honors
- 2023 Elected member of the U.S. National Academy of Sciences{{Cite web|url=https://www.nasonline.org/news-and-multimedia/news/2023-nas-election.html|title=2023 NAS Election|date=2023-05-02|website=National Academy of Sciences|access-date=2023-05-02}}
- 2018 Appointed as Sterling Professor of Molecular, Cellular, and Developmental Biology{{Cite web|url=https://news.yale.edu/2018/07/19/anna-marie-pyle-appointed-sterling-professor|title=Anna Marie Pyle appointed Sterling Professor|date=2018-07-19|website=YaleNews|access-date=2019-03-01}}
- 2007 Elected American Association for the Advancement of Science (AAAS) Fellow{{Cite web|url=https://www.aaas.org/fellows/historic|title=Historic Fellows|website=American Association for the Advancement of Science|access-date=2019-03-01}}
- 2005 Appointed member of the American Academy of Arts and Sciences{{Cite web|url=https://www.amacad.org/person/anna-marie-pyle|title=Anna Marie Pyle|website=American Academy of Arts & Sciences|access-date=2019-03-01}}
References
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Category:Yale University faculty
Category:Yale Sterling Professors
Category:Princeton University alumni
Category:American women biochemists
Category:Howard Hughes Medical Investigators
Category:Year of birth missing (living people)
Category:People from Albuquerque, New Mexico
Category:Columbia Graduate School of Arts and Sciences alumni
Category:University of Colorado Boulder alumni
Category:Place of birth missing (living people)
Category:Fellows of the American Association for the Advancement of Science
Category:Fellows of the American Academy of Arts and Sciences