INPP1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{multiple issues|

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Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene.{{cite journal |vauthors=York JD, Veile RA, Donis-Keller H, Majerus PW | title = Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 12 | pages = 5833–7 |date=Jul 1993 | pmid = 8390685 | pmc = 46817 | doi =10.1073/pnas.90.12.5833 | bibcode = 1993PNAS...90.5833Y | doi-access = free }}{{cite web | title = Entrez Gene: INPP1 inositol polyphosphate-1-phosphatase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3628| access-date = 2012-07-31}}

INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.

References

{{cite journal |vauthors=Majerus PW, Ross TS, Cunningham TW, etal |title=Recent insights in phosphatidylinositol signaling. |journal=Cell |volume=63 |issue= 3 |pages= 459–65 |year= 1990 |pmid= 2225061 |doi=10.1016/0092-8674(90)90442-H |s2cid=29563486 }}
{{cite journal |vauthors=Zhang X, Majerus PW |title=Phosphatidylinositol signalling reactions. |journal=Semin. Cell Dev. Biol. |volume=9 |issue= 2 |pages= 153–60 |year= 1998 |pmid= 9599410 |doi= 10.1006/scdb.1997.0220 }}
{{cite journal |vauthors=Steen VM, Løvlie R, Osher Y, etal |title=The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness. |journal=Pharmacogenetics |volume=8 |issue= 3 |pages= 259–68 |year= 1998 |pmid= 9682271 |doi= 10.1097/00008571-199806000-00008}}
{{cite journal |vauthors=Løvlie R, Gulbrandsen AK, Molven A, Steen VM |title=Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1). |journal=Pharmacogenetics |volume=9 |issue= 4 |pages= 517–28 |year= 2000 |pmid= 10780272 }}
{{cite journal |vauthors=Patel S, Yenush L, Rodríguez PL, etal |title=Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. |journal=J. Mol. Biol. |volume=315 |issue= 4 |pages= 677–85 |year= 2002 |pmid= 11812139 |doi= 10.1006/jmbi.2001.5271 }}
{{cite journal |vauthors=Piccardi MP, Ardau R, Chillotti C, etal |title=Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes. |journal=Psychiatr. Genet. |volume=12 |issue= 1 |pages= 23–7 |year= 2002 |pmid= 11901356 |doi=10.1097/00041444-200203000-00003 |s2cid=24222446 }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

Category:Genes mutated in mice

INPP1

References

Further reading