acridone synthase
{{Short description|Class of enzymes}}
{{infobox enzyme
| Name = acridone synthase
| EC_number = 2.3.1.159
| CAS_number = 99085-53-7
| GO_code = 0050635
| image =
| width =
| caption =
}}
In enzymology, an acridone synthase ({{EC number|2.3.1.159}}) is an enzyme that catalyzes the chemical reaction
:3 malonyl-CoA + N-methylanthraniloyl-CoA 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2
Thus, the two substrates of this enzyme are malonyl-CoA and N-methylanthraniloyl-CoA, whereas its 3 products are CoA, 1,3-dihydroxy-N-methylacridone, and CO2.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing). This enzyme participates in acridone alkaloid biosynthesis.
References
{{reflist|1}}
- {{cite journal |vauthors=Baumert A, Maier W, Gröger D, Deutzmann R | date = 1994 | title = Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L | journal = Z. Naturforsch. C | volume = 49 | pages = 26–32 | pmid = 8148006 | issue = 1-2 }}
- {{cite journal |vauthors=Maier W, Baumert A, Schumann B, Furukawa H, Gröger D | date = 1993 | title = Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures | journal = Phytochemistry | volume = 32 | issue = 3 | pages = 691–698 | doi = 10.1016/S0031-9422(00)95155-0 }}
- {{cite journal | author = Matern U | date = 1999 | title = Native acridone synthases I and II from Ruta graveolens L. form homodimers | journal = FEBS Lett. | volume = 448 | pages = 135–40 | pmid = 10217426 | doi = 10.1016/S0014-5793(99)00355-5 | last2 = Springob | first2 = K | last3 = Urbanke | first3 = C | last4 = Ernwein | first4 = C | last5 = Schröder | first5 = G | last6 = Schröder | first6 = J | last7 = Matern | first7 = U | issue = 1 | doi-access = }}
- {{cite journal |vauthors=Junghanns KT, Kneusel RE, Gröger D, Matern U | date = 1998 | title = Differential regulation and distribution of acridone synthase in Ruta graveolens | journal = Phytochemistry | volume = 49 | pages = 403–11 | pmid = 9747538 | doi = 10.1016/S0031-9422(98)00104-6 | issue = 2 }}
{{Acyltransferases}}
{{Enzymes}}
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Category:Enzymes of unknown structure
{{2.3-enzyme-stub}}