agmatine deiminase
{{Short description|InterPro Family}}
{{infobox enzyme
| Name = agmatine deiminase
| EC_number = 3.5.3.12
| CAS_number = 37289-17-1
| GO_code = 0047632
| image =
| width =
| caption =
}}
In enzymology, an agmatine deiminase ({{EC number|3.5.3.12}}) is an enzyme that catalyzes the chemical reaction
:agmatine + H2O N-carbamoylputrescine + NH3
Thus, the two substrates of this enzyme are agmatine and H2O, whereas its two products are N-carbamoylputrescine and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine iminohydrolase. This enzyme is also called agmatine amidinohydrolase. This enzyme participates in urea cycle and metabolism of amino groups.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1VKP}}, {{PDB link|2EWO}}, {{PDB link|2JER}}, and {{PDB link|2Q3U}}.
References
{{reflist|1}}
- {{cite journal | author = Smith TA | date = 1969 | title = Agmatine iminohydrolase in maize | journal = Phytochemistry | volume = 8 | pages = 2111–2117 | doi = 10.1016/S0031-9422(00)88168-6 | issue = 11 }}
- {{cite journal |vauthors=Srivenugopal KS, Adiga PR | date = 1981 | title = Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase) | journal = J. Biol. Chem. | volume = 256 | pages = 9532–41 | pmid = 6895223 | issue = 18 | doi = 10.1016/S0021-9258(19)68795-8 | doi-access = free }}
{{Carbon-nitrogen non-peptide hydrolases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
Category:Enzymes of known structure
{{3.5-enzyme-stub}}