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amino acid transporter

{{Short description|Membrane transport proteins}}

{{Infobox protein family

| Symbol = Aa_trans

| Name = Transmembrane amino acid transporter protein

| image =

| width =

| caption =

| Pfam= PF01490

| InterPro= IPR013057

| SMART=

| Prosite =

| SCOP =

| TCDB = 2.A.18

| OPM family=

| OPM protein=

| PDB=

| Membranome superfamily = 228

}}

An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.

Families

There are several families that function in amino acid transport, some of these include:

Solute carrier family examples

  • (1) high affinity glutamate and neutral amino acid transporter{{cite journal |vauthors =Kanai Y, Hediger MA|title=The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects|journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 469–479 |year= 2004|doi= 10.1007/s00424-003-1146-4 |pmid= 14530974|s2cid=21564906}}
  • (3) heavy subunits of heteromeric amino acid transporters{{cite journal |vauthors =Palacin M, Kanai Y|title=The ancillary proteins of HATs: SLC3 family of amino acid transporters|journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 490–494 |year= 2004|doi= 10.1007/s00424-003-1062-7 |pmid= 14770309|s2cid=25808108}}
  • (6) Bacterial Leucine Transporter (LeuT){{cite journal |vauthors =Singh SK, Piscitelli CL, Yamashita A, Gouaux E|title=A competitive inhibitor traps LeuT in an open-to-out conformation|journal= Science |volume= 322 |issue= 5908 |pages= 1655–1661 |year= 2008|doi=10.1126/science.1166777 |pmid= 19074341 |pmc=2832577|bibcode=2008Sci...322.1655S}}
  • (7) cationic amino acid transporter/glycoprotein-associated{{cite journal |vauthors =Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y |title=CATs and HATs: the SLC7 family of amino acid transporters |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 532–542 |year= 2004 |doi = 10.1007/s00424-003-1086-z |pmid= 14770310|s2cid=11670040 |url=http://doc.rero.ch/record/317805/files/424_2003_Article_1086.pdf }}
  • (15) proton oligopeptide cotransporter{{cite journal |vauthors =Daniel H, Kottra G |title=The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 610–618 |year= 2004 |doi = 10.1007/s00424-003-1101-4 |pmid= 12905028|s2cid=22369521 }}
  • (17) vesicular glutamate transporter{{cite journal |vauthors =Reimer RJ, Edwards RH |title=Organic anion transport is the primary function of the SLC17/type I phosphate transporter family |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 629–635 |year= 2004 |doi = 10.1007/s00424-003-1087-y |pmid= 12811560|s2cid=9680597 }}
  • (18) vesicular amine transporter{{cite journal |vauthors =Eiden LE, Schafer MK, Weihe E, Schutz B |title=The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 636–640 |year= 2004 |doi = 10.1007/s00424-003-1100-5 |pmid= 12827358|s2cid=20764857 }}
  • (25) some mitochondrial carriers{{cite journal |author =Palmieri F |title=The mitochondrial transporter family (SLC25): physiological and pathological implications |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 689–709 |year= 2004 |doi = 10.1007/s00424-003-1099-7 |pmid= 14598172|s2cid=25304722 }}
  • (26) multifunctional anion exchanger{{cite journal |vauthors =Mount DB, Romero MF |title=The SLC26 gene family of multifunctional anion exchangers |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 710–721 |year= 2004 |doi = 10.1007/s00424-003-1090-3 |pmid= 12759755|s2cid=20302398 }}
  • (32) vesicular inhibitory amino acid transporter{{cite journal |author =Gasnier B |title=The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 752–755 |year= 2004 |doi = 10.1007/s00424-003-1091-2 |pmid= 12750892|s2cid=24669893 }}
  • (36) proton-coupled amino acid transporter{{cite journal |vauthors =Boll M, Daniel H, Gasnier B |title=The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 776–779 |year= 2004 |doi = 10.1007/s00424-003-1073-4 |pmid= 12748860|s2cid=25655241 }}
  • (38) System A & N, sodium-coupled neutral amino acid transporter{{cite journal |vauthors =Mackenzie B, Erickson JD |title=Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family |journal= Pflügers Arch |volume= 447 |issue= 5 |pages= 784–795 |year= 2004 |doi = 10.1007/s00424-003-1117-9 |pmid= 12845534|s2cid=35457147 }}

===VIAAT===

Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003

Human proteins containing this domain

SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6.

See also

References

{{reflist}}

{{GABA metabolism and transport modulators}}

{{Glutamate metabolism and transport modulators}}

Category:Solute carrier family