ancestim
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| routes_of_administration = s.c. injection only, premedication with H1 and H2 antihistamines and beta-receptor agonists for bronchodilation
| bioavailability =
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| elimination_half-life = 2.5 h
| excretion = renal: 90%
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| CAS_number = 163545-26-4
| ATC_prefix = L03
| ATC_suffix = AA12
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| UNII = PYB4Q6JG41
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Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish Orphan Biovitrum, in December, 2008.Amgen press office. [http://www.amgen.com/media/biovitrum_amgen_deal.html Biovitrum Closes Product Acquisition Deal with Amgen] {{webarchive |url=https://web.archive.org/web/20120703015728/http://www.amgen.com/media/biovitrum_amgen_deal.html |date=July 3, 2012 }}
It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell factor.{{cite journal |vauthors=da Silva MG, Pimentel P, Carvalhais A |title=Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection |journal=Bone Marrow Transplant. |volume=34 |issue=8 |pages=683–91 |year=2004 |pmid=15322567 |doi=10.1038/sj.bmt.1704602|display-authors=etal|doi-access= |s2cid=21830065 }} It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine retained after expression in E. coli. Because Ancestim is produced in E. coli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised powder for reconstitution and administration as a subcutaneous (SC) injection and is indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later transplantation in certain cancer patients.{{cite web |url=http://www.sobi.com/en/Healthcare-Professionals/Products-alphabetical-list/Stemgen/ |title=Sobi's StemGen page |access-date=2013-12-30 |archive-url=https://web.archive.org/web/20160729205744/http://www.sobi.com/en/Healthcare-Professionals/Products-alphabetical-list/Stemgen/ |archive-date=2016-07-29 |url-status=dead }}