anorexia (symptom)

The term is from {{Langx|grc|ανορεξία}} ({{lang|grc|ἀν-}}, 'without' + {{lang|grc|όρεξις}}, spelled {{transliteration|grc|órexis}}, meaning 'appetite').{{cite book |last=Psyhogeos|first=Matina|date=14 April 2016|title=English Words Deriving from the Greek Language|publisher=Page Publishing Incorporated |url=https://books.google.com/books?id=1CX4CwAAQBAJ&pg=PT159|editor=Page Publishing Inc.|isbn=978-1682134283}}

Anorexia simply manifests as a decreased or loss of appetite. This can present as not feeling hungry or lacking the desire to eat.{{Cite web|title=Loss of Appetite - Digestive Disorders|url=https://www.merckmanuals.com/en-ca/home/digestive-disorders/symptoms-of-digestive-disorders/loss-of-appetite|access-date=2021-10-27|website=Merck Manuals Consumer Version|language=en-CA}} Sometimes people do not even notice they lack an appetite until they begin to lose weight from eating less. In other cases, it can be more noticeable, such as when a person becomes nauseated from just the thought of eating. Any form of decreased appetite that leads to changes in the body (such as weight loss or muscle loss) that is not done intentionally as part of dieting is clinically significant.{{Cite book|title=Endocrinology: Adult and Pediatric|last=Jameson|first=Larry|publisher=Saunders|year=2016|isbn=978-0-323-18907-1|location=Philadelphia, PA|pages=506–510}}

Appetite stimulation and suppression is a complex process involving many different parts of the brain and body by the use of various hormones and signals. Appetite is thought to be stimulated by interplay between peripheral signals to the brain (taste, smell, sight, gut hormones) as well as the balance of neurotransmitters and neuropeptides in the hypothalamus. Examples of these signals or hormones include neuropeptide Y, leptin, ghrelin, insulin, serotonin, and orexins (also called hypocretins). Anything that causes an imbalance of these signals or hormones can lead to the symptom of anorexia. While it is known that these signals and hormones help control appetite, the complicated mechanisms regarding a pathological increase or decrease in appetite are still being explored.

• Acute radiation syndrome
• ADHD
• Addison's disease
• Alcoholism
• Alcohol withdrawal
• Anemia
• Anorexia nervosa
• Anxiety
• Appendicitis
• Babesiosis
• Benzodiazepine withdrawal
• Bipolar disorder
• Bronchitis
• Cancer{{Cite web|title=Loss of Appetite|url=https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/eating-problems/poor-appetite.html|access-date=2021-10-27|website=www.cancer.org|language=en}}{{Cite web|title=Loss of appetite|url=https://cancer.ca/en/treatments/side-effects/loss-of-appetite|url-status=live|website=Canadian Cancer Society|date=December 2019 |archive-url=https://web.archive.org/web/20211027134339/https://cancer.ca/en/treatments/side-effects/loss-of-appetite |archive-date=2021-10-27 }}
• Cannabinoid hyperemesis syndrome
• Cannabis withdrawal
• Celiac disease{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK1727/|title=Celiac Disease|vauthors=Taylor AK, Lebwohl B, Snyder CL, Green PH|publisher=GeneReviews®|date=17 September 2015|pmid=20301720 |access-date=24 September 2017}}
• Chronic kidney disease
• Chronic pain
• Common cold
• Constipation
• COPD
• COVID-19
• Crohn's disease
• Cystic fibrosis
• Dehydration
• Dementia
• Depression
• Diabetes
• Ebola
• Fatty liver disease
• Fever
• Food poisoning
• Gastroparesis
• Heart failure
• Hepatitis
• HIV/AIDS
• Hypercalcemia
• Hyperglycemia
• Hypervitaminosis D
• Hypothyroidism and sometimes hyperthyroidism
• Influenza
• Irritable bowel syndrome
• Ketoacidosis
• Kidney failure{{Cite news|url=https://www.emedicinehealth.com/script/main/mobileart-emh.asp?articlekey=80651&questionid=7|title=Pinworms in Kids & Adults: Pictures, Symptoms & Treatments Viewer Comments and Reviews: Hypothyroidism - Symptoms - Patients Share Their Knowledge on eMedicineHealth|work=eMedicineHealth|access-date=2017-11-28|archive-date=2015-10-04|archive-url=https://web.archive.org/web/20151004020557/http://www.emedicinehealth.com/script/main/mobileart-emh.asp?articlekey=80651&questionid=7|url-status=dead}}
• Low blood pressure
• Macroglossia
• Mania
• Metabolic disorders, particularly urea cycle disorders
• MELAS syndrome
• Nausea
• Old age
• Opioid use disorder
• Pancreatitis
• Pernicious anemia (vitamin B₁₂ deficiency)
• Pneumonia
• Psychosis
• Schizophrenia
• Side effect of drugs
• Stimulant use disorder
• Stomach flu
• Stress
• Sickness behavior{{Cite journal|last1=Exton|first1=M. S.|title=Infection-Induced Anorexia: Active Host Defence Strategy|doi=10.1006/appe.1997.0116|journal=Appetite|volume=2|issue=3|pages=369–383|year=1997|pmid=9468766|s2cid=10465902}}{{Cite journal|last1=Murray|first1=M. J.|last2=Murray|first2=A. B.|title=Anorexia of infection as a mechanism of host defense|journal=The American Journal of Clinical Nutrition|volume=32|issue=3|pages=593–596|year=1979|pmid=283688|doi=10.1093/ajcn/32.3.593}}
• Superior mesenteric artery syndrome
• Syndrome of inappropriate antidiuretic hormone secretion{{cite journal |last1=Winston |first1=Anthony P |title=The clinical biochemistry of anorexia nervosa |journal=Annals of Clinical Biochemistry: International Journal of Laboratory Medicine |date=March 2012 |volume=49 |issue=2 |pages=132–143 |doi=10.1258/acb.2011.011185|pmid=22349551 |s2cid=207193656 |doi-access=free }}
• Tobacco smoking
• Tuberculosis
• Thalassemia
• Ulcerative colitis
• Uremia{{cite journal |last1=Aguilera |first1=A |last2=Selgas |first2=R |last3=Codoceo |first3=R |last4=Bajo |first4=A |title=Uremic anorexia: a consequence of persistently high brain serotonin levels? The tryptophan/serotonin disorder hypothesis. |journal=Peritoneal Dialysis International |date=November 2000 |volume=20 |issue=6 |pages=810–6 |doi=10.1177/089686080002000648 |pmid=11216590|s2cid=1731116 |doi-access=free }}
• Folate deficiency
• Zinc deficiency
• Infection: Anorexia of infection is part of the acute phase response (APR) to infection. The APR can be triggered by lipopolysaccharides and peptidoglycans from bacterial cell walls, bacterial DNA, and double-stranded viral RNA, and viral glycoproteins, which can trigger production of a variety of proinflammatory cytokines. These can have an indirect effect on appetite by a number of means, including peripheral afferents from their sites of production in the body, by enhancing production of leptin from fat stores. Inflammatory cytokines can also signal to the central nervous system more directly by specialized transport mechanisms through the blood–brain barrier, via circumventricular organs (which are outside the barrier), or by triggering production of eicosanoids in the endothelial cells of the brain vasculature. Ultimately, the control of appetite by this mechanism is thought to be mediated by the same factors normally controlling appetite, such as neurotransmitters (serotonin, dopamine, histamine, norepinephrine, corticotropin releasing factor, neuropeptide Y, and α-melanocyte-stimulating hormone).{{cite journal|author=Langhans W.|title=Anorexia of infection: current prospects|journal=Nutrition|volume=16|issue=10|pages=996–1005|date=October 2000|pmid=11054606|doi=10.1016/s0899-9007(00)00421-4}}

{{main | Anorectic}}

• Stimulants, such as ephedrine, amphetamine, methamphetamine, MDMA, cathinone, methylphenidate, cocaine, etc.
• Hormones which are produced by adrenal glands and used as medication such as adrenaline.
• Narcotics, such as heroin, morphine, codeine, hydrocodone, oxycodone, etc.
• Antidepressants may have anorexia as a side effect, primarily selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine.
• Byetta, a type II diabetes drug, will cause moderate nausea and loss of appetite.
• Abruptly stopping appetite-increasing drugs, such as cannabis and corticosteroids.
• Chemicals that are members of the phenethylamine group. (Individuals with anorexia nervosa may seek them to suppress appetite.)
• Topiramate may cause anorexia as a side effect.
• Other drugs may be used to intentionally cause anorexia in order to help a patient preoperative fasting prior to general anesthesia. It is important to avoid food before surgery to mitigate the risk of pulmonary aspiration, which can be fatal.

• During the post-operative recovery period for a tonsillectomy or adenoidectomy, it is common for adult patients to experience a lack of appetite until their throat significantly heals (usually 10–14 days).{{cite web|url=http://www.umhc.com/oth/Page.asp?PageID=OTH001009|title=Home Care After Tonsillectomy and Adenoidectomy|url-status=dead|archive-url=https://web.archive.org/web/20110717153234/http://www.umhc.com/oth/Page.asp?PageID=OTH001009|archive-date=July 17, 2011}}
• Allergy
• Altitude sickness
• Airsickness
• Significant emotional pain caused by an event (rather than a mental disorder) can cause an individual to temporarily lose all interest in food.
• Several Twelve-step programs including Overeaters Anonymous tackle psychological issues members believe lead to forms of deprivation
• Psychological stress
• Toothache
• Experiencing grotesque, unpleasant or unappealing thoughts or conversations
• Being in the presence of unappealing things such as waste matter, dead organisms, or bad smells

Complications of anorexia may result due to poor food intake. Poor food intake can lead to dehydration, electrolyte imbalances, anemia and nutritional deficiencies. These imbalances will worsen the longer that food is avoided.

Anorexia is a relatively common condition that can lead patients to have dangerous electrolyte imbalances, leading to acquired long QT syndrome which can result in sudden cardiac death. This can develop over a prolonged period of time, and the risk is further heightened when feeding resumes after a period of abstaining from consumption.

Care must be taken when a patient begins to eat after prolonged starvation to avoid the potentially fatal complications of refeeding syndrome. The initial signs of refeeding syndrome are minimal, but can rapidly progress to death. Thus, the reinitiation of food or oral intake is usually started slowly and requires close observation under supervision by trained healthcare professionals. This is usually done in a hospital or nutritional rehabilitation center.{{cite journal|last1=Jáuregui-Garrido|first1=B.|last2=Jáuregui-Lobera|first2=I.|title=Sudden death in eating disorders|journal=Vascular Health and Risk Management|date=2012|volume=8|pages=91–98|pmid=22393299|pmc=3292410|doi=10.2147/VHRM.S28652 |doi-access=free }}

Anorexia can be treated with the help of orexigenic drugs.{{Cite journal |last=Thomas |first=David R. |date=February 2006 |title=Guidelines for the Use of Orexigenic Drugs in Long-Term Care |url=http://doi.wiley.com/10.1177/011542650602100182 |journal=Nutrition in Clinical Practice |language=en |volume=21 |issue=1 |pages=82–87 |doi=10.1177/011542650602100182 |pmid=16439773 |issn=0884-5336}}{{Cite journal |last1=Viswambharan |first1=Vishal |last2=Manepalli |first2=Jothika N |last3=Grossberg |first3=George T |date=February 2013 |title=Orexigenic agents in geriatric clinical practice |url=https://www.futuremedicine.com/doi/10.2217/ahe.12.83 |journal=Aging Health |language=en |volume=9 |issue=1 |pages=49–65 |doi=10.2217/ahe.12.83 |issn=1745-509X}}

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{{Medical resources

| MedlinePlus =000362

| ICD10 = {{ICD10|R|63|0|r|50}}

| ICD9 = {{ICD9|783.0}}

| MeshID = D000855

}}

{{Nutritional pathology}}

{{General symptoms and signs}}

{{Common Cold}}

{{Authority control}}

Category:Symptoms and signs: Endocrinology, nutrition, and metabolism

Category:Eating disorders