antisialagogue

{{Short description|Drugs that decrease the flow rate of saliva}}

Antisialagogues are drugs or substances that decrease the flow rate of saliva and their effect is opposite to that of sialagogues.{{cite book | vauthors = Dock LL | title = Text-Book Of Materia Medica For Nurses | chapter = Drugs Acting On The Salivary Glands | publisher = G. P. Putnam's Sons | date = 1916 | chapter-url = http://chestofbooks.com/health/materia-medica-drugs/Textbook-of-Materia-Medica-For-Nurses/The-Digestive-System.html | access-date = 15 October 2010 }} Their origin may be both natural and synthetic.

Anticholinergics generally have antisialagogue effects, and most produce some level of sedation, both being advantageous in surgical procedures.{{cite book | vauthors = Hata TM, Moyers JR | chapter = Preoperative Patient Assessment and Management | veditors = Cahalan MD, Barash PG, Cullen BF, Stoelting RK |title=Clinical Anesthesia |publisher=Lippincott Williams & Wilkins |location=Hagerstwon, MD |year=2009 |isbn=978-0-7817-8763-5 | page = 592 | chapter-url = https://books.google.com/books?id=-YI9P2DLe9UC&q=592&pg=PA592 }}

Classic antisialagogues include:

• atropine,
• opioids,
• alkalis,
• hyoscyamine,
• scopolamine,
• tobacco in excess,
• most cannabinoids,{{cite web |last1=Prestifilippo |first1=Juan Pablo |last2=Fernández-Solari |first2=Javier |last3=de la Cal |first3=Carolina |last4=Iribarne |first4=María |last5=Suburo |first5=Angela M. |last6=Rettori |first6=Valeria |last7=McCann |first7=Samuel M. |last8=Elverdin |first8=Juan Carlos |title=Inhibition of salivary secretion by activation of cannabinoid receptors |url=https://pubmed.ncbi.nlm.nih.gov/16946411/ |website=Experimental Biology and Medicine (Maywood, N.J.) |access-date=17 June 2023 |pages=1421–1429 |doi=10.1177/153537020623100816 |date=September 2006}}
• all nauseous or insipid substances.