arachnodactyly
{{Infobox medical condition (new)
| name = Arachnodactyly
| image = Aracnodactilia.jpg
| caption = Bilateral arachnodactyly
| synonyms = Achromachia
| complications = None
| onset = Birth
| duration = Life-long
| types =
| causes = Mutations in the fibrillin-2 gene, in chromosome 5q23, or the fibrillin-1 gene, at chromosome 15q21.1
| risks =
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Arachnodactyly ("spider fingers") is a medical condition that is characterized by fingers and toes that are abnormally long and slender, in comparison to the palm of the hand and arch of the foot. In some cases, the thumbs of an individual with the condition are pulled inwards towards the palm. This condition is present at birth.
Causes
This feature can occur on its own with no underlying health problems,{{cite web | author=Cleveland Clinic medical professional | title=Arachnodactyly: Do You Have Spider Fingers? | website=Cleveland Clinic | date=2024-10-30 | url=https://my.clevelandclinic.org/health/symptoms/arachnodactyly | access-date=2025-03-15}} or it can be associated with certain medical conditions, including Marfan syndrome,{{Cite journal| pmid = 1856834| date = April 1991| last1 = Buntinx | first1 = I. M.| last2 = Willems | first2 = P. J.| last3 = Spitaels | first3 = S. E.| last4 = Van Reempst | first4 = P. J.| last5 = De Paepe | first5 = A. M.| last6 = Dumon | first6 = J. E.| title = Neonatal Marfan syndrome with congenital arachnodactyly, flexion contractures, and severe cardiac valve insufficiency| volume = 28| issue = 4| pages = 267–273| issn = 0022-2593| pmc = 1016831| journal = Journal of Medical Genetics| doi = 10.1136/jmg.28.4.267}} Ehlers–Danlos syndromes,{{Cite book | title = Hypermobility syndrome: Recognition and management for physiotherapists | isbn = 978-0-7506-5390-9 | last1 = Keer | first1 = Rosemary | last2 = Grahame | first2 = Rodney | date = 2003-06-27 | publisher = Butterworth Heinemann }} Loeys–Dietz syndrome, and homocystinuria.{{Cite web| last1 = Pagon | first1 = RA. | last2 = Bird | first2 = TC. | last3 = Dolan | first3 = CR. | last4 = Stephens | first4 = K. | last5 = Picker | first5 = JD. | last6 = Levy | first6 = HL. | title = Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency | year = 1993| pmid = 20301697 |url=https://www.ncbi.nlm.nih.gov/books/NBK1524/}} It is also seen in congenital contractural arachnodactyly,{{cite journal |last1=Viljoen |first1=D. |date=1994 |title=Congenital contractural arachnodactyly (Beals syndrome) |journal=Journal of Medical Genetics |volume=31 |issue=8 |pages=640–643 |doi=10.1136/jmg.31.8.640 |pmc=1050028 |pmid=7815423}} which is caused by mutation in the gene encoding fibrillin-2 on chromosome 5q23.{{Cite journal |last1=Hecht |first1=Frederick |last2=Beals |first2=Rodney K. |title="New" Syndrome of Congenital Contractural Arachnodactyly, Originally Described by Marfan in 1896 |date=1972-04-01 |url=http://dx.doi.org/10.1542/peds.49.4.574 |journal=Pediatrics |volume=49 |issue=4 |pages=574–579 |doi=10.1542/peds.49.4.574 |pmid=4552107 |s2cid=1846022 |issn=0031-4005 |access-date=2022-03-17 |archive-date=2023-02-22 |archive-url=https://web.archive.org/web/20230222225944/https://publications.aap.org/pediatrics/article-abstract/49/4/574/47115/NEW-SYNDROME-OF-CONGENITAL-CONTRACTURAL?redirectedFrom=fulltext%3Fautologincheck%3Dredirected |url-status=live |url-access=subscription }}
Notable cases
It remains unconfirmed whether composer Sergei Rachmaninoff's abnormally large reach on a piano was a result of arachnodactyly due to Marfan syndrome, as the pianist exhibited no other signs of the disease.{{Cite web | url=http://www.rachmaninoff.org/board/search.php?keywords=Rachmaninoff+marfan&t=480&sf=msgonly&sid=f27659d850755a3aa29de5eeb1eb969a | title=Forum - Search results for Rachmaninoff Marfan | date=7 September 2016 | publisher=Website of the Rachmaninoff Network | access-date=4 August 2020 }}{{Dead link|date=July 2023 |bot=InternetArchiveBot |fix-attempted=yes }}
See also
References
{{reflist}}
External links
{{Medical resources
| DiseasesDB = 15196
| ICD10 = {{ICD10|Q|87|4|q|80}} (ILDS Q87.410)
| ICD9 = {{ICD9|759.82}}
| ICDO =
| OMIM =
| MedlinePlus = 003288
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| MeshID = D008382
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{{Commons category|Arachnodactyly}}
{{Congenital malformations and deformations of musculoskeletal system}}