asialoglycoprotein

{{Short description|Class of glycoproteins from which sialic acid has been removed by the action of sialidases}}

If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.{{Cite journal |last1=Gross |first1=Hans Jürgen |last2=Brossmer |first2=Reinhard |date=1987-06-01 |title=N-Acetyl-4-deoxy-d-neuraminic acid is activated and transferred on to asialoglycoprotein |url=https://doi.org/10.1007/BF01049452 |journal=Glycoconjugate Journal |language=en |volume=4 |issue=2 |pages=145–156 |doi=10.1007/BF01049452 |s2cid=7911178 |issn=1573-4986|url-access=subscription }}{{Cite journal |last1=Regoeczi |first1=E. |last2=Chindemi |first2=P. A. |date=1981-01-01 |title=The net weight of the rabbit liver and its relevance for asialoglycoprotein clearance |url=https://europepmc.org/article/med/7227848 |journal=Growth |volume=45 |issue=1 |pages=19–28 |issn=0017-4793 |pmid=7227848}}

In rats, the exposure of subterminal galactose or GalNAc residues may assist in receptor-mediated endocytosis of asialoglycoproteins by asialoglycoprotein receptors on Kuppfer cells. The human ortholog of this gene is non-functional, but hepatocyte asialoglycoprotein receptors are functional in both humans and rats.{{cite journal|vauthors=Fadden AJ, Holt OJ, Drickamer K|journal=Glycobiology|volume=13|issue=7|year=2003|pages=529-537|doi=10.1093/glycob/cwg068|pmid=12672702|doi-access=free|title=Molecular characterization of the rat Kupffer cell glycoprotein receptor}}