at risk mental state

At risk mental state is the clinical presentation of those considered at risk of developing psychosis or schizophrenia.{{cite journal |vauthors=Yung AR, McGorry PD, McFarlane CA, Jackson HJ, Patton GC, Rakkar A |title=Monitoring and care of young people at incipient risk of psychosis |journal=Schizophr Bull |volume=22 |issue=2 |pages=283–303 |year=1996 |pmid=8782287 |doi= 10.1093/schbul/22.2.283|doi-access=free }} Such states were formerly considered treated as prodromes, emerging symptoms of psychosis, but this view is no longer prevalent as a prodromal period cannot be confirmed unless the emergence of the condition has occurred.{{cn|date=December 2021}}

The original specialist service for those with subclinical symptoms of psychosis was The Pace Clinic{{Cite web |url=http://www.orygen.org.au/contentPage.asp?pageCode=ATRISK |title=ORYGEN Youth Health |access-date=2011-08-04 |archive-url=https://web.archive.org/web/20091024170333/http://www.orygen.org.au/contentPage.asp?pageCode=ATRISK#paceclin |archive-date=2009-10-24 |url-status=dead }} in Melbourne, Australia.{{cite journal |doi=10.1093/schbul/22.2.283 |vauthors=Yung AR, McGorry PD, McFarlane CA, Jackson HJ, Patton GC, Rakkar A |title=Monitoring and care of young people at incipient risk of psychosis |journal=Schizophr Bull |volume=22 |issue=2 |pages=283–303 |year=1996 |pmid=8782287 |doi-access=free }} Other clinics have since developed around the world.{{cite journal |vauthors=Broome MR, Woolley JB, Johns LC |title=Outreach and support in south London (OASIS): implementation of a clinical service for prodromal psychosis and the at risk mental state |journal=Eur. Psychiatry |volume=20 |issue=5–6 |pages=372–8 |date=August 2005 |pmid=16171652 |doi=10.1016/j.eurpsy.2005.03.001 |s2cid=27207646 |display-authors=etal}}[http://info.med.yale.edu/psych/clinics/prime/pintro.html PRIME][http://www.copeclinic.org/The_COPE_Clinic_at_Columbia_Psychiatry.html (COPE)]{{Cite web |url=http://www.psychology.emory.edu/clinical/walker/index.html |title=Emory University |access-date=2011-08-04 |archive-url=https://web.archive.org/web/20110722053413/http://www.psychology.emory.edu/clinical/walker/index.html |archive-date=2011-07-22 |url-status=dead }}

There has been some considerable development of how the concept can be applied clinically.{{cite journal |vauthors=Yung AR, Phillips LJ, Yuen HP |title=Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group |journal=Schizophr. Res. |volume=60 |issue=1 |pages=21–32 |date=March 2003 |pmid=12505135 |doi= 10.1016/S0920-9964(02)00167-6|s2cid=31342026 |display-authors=etal}}{{cite journal|display-authors=etal|vauthors=McGorry PD, Yung AR, Phillips LJ|date=October 2002|title=Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms|url=https://jamanetwork.com/journals/jamapsychiatry/fullarticle/206778|journal=Arch. Gen. Psychiatry|volume=59|issue=10|pages=921–8|doi=10.1001/archpsyc.59.10.921|pmid=12365879|doi-access=free|hdl=10536/DRO/DU:30151296|hdl-access=free}}{{cite journal |vauthors=Morrison AP, French P, Parker S |title=Three-year follow-up of a randomized controlled trial of cognitive therapy for the prevention of psychosis in people at ultrahigh risk |journal=Schizophr Bull |volume=33 |issue=3 |pages=682–7 |date=May 2007 |pmid=16973786 |pmc=2526150 |doi=10.1093/schbul/sbl042|display-authors=etal}}{{cite journal | author = Schäfer Amminger |author2=Papageorgiou Harrigan |author3=Cotton McGorry, Berger | year = 2008 | title = Indicated Prevention of Psychotic Disorders with Long-Chainomega-3 Fatty Acids: A Randomized, Placebo-Controlled Trial | journal = Schizophrenia Research | volume = 102 | issue = 1–3| page = 252 | doi=10.1016/s0920-9964(08)70758-8|s2cid=53301111 }}

Assessed during the structured interview developed by PACE{{clarify|date=February 2013}}.{{cite journal |vauthors=Yung AR, Yuen HP, McGorry PD |title=Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States |journal=Aust N Z J Psychiatry |volume=39 |issue=11–12 |pages=964–71 |year=2005 |pmid=16343296 |doi=10.1080/j.1440-1614.2005.01714.x |s2cid=145477493 |display-authors=etal}}