benzylpenicilloyl polylysine

{{Short description|Chemical compound}}

{{Drugbox

| Verifiedfields = changed

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| verifiedrevid = 459813303

| IUPAC_name = [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate : L-Lysine homopolymer

| image = Benzylpenicilloyl polylysine (structural diagram).png

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| tradename = Pre-Pen

| licence_EU =

| licence_US = Pre-Pen

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| legal_US = Rx-only

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| routes_of_administration = Liquid intradermal

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| CAS_number = 31855-75-1

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| UNII = 76479814OY

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| DrugBank = DB00895

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| ChEMBL = 1201779

| synonyms = Pre-Pen

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Benzylpenicilloyl polylysine (Pre-Pen) is used as a skin test before the administration of penicillin. It is used to detect the immunoglobulin E antibodies.{{Cite web | title = Benzylpenicilloyl polylysine

| url=http://www.pharmgkb.org/do/serve?objId=PA164754810&objCls=Drug | work = PharmGKB}}{{Cite web | url=http://www.drugbank.ca/drugs/DB00895 | title=Benzylpenicilloyl polylysine | work = DrugBank }} The chemical structure consists of the benzylpenicilloyl group attached to a polymer of L-lysine.{{cite journal | vauthors = Vemuri P, Harris KE, Suh LA, Grammer LC | title = Preparation of benzylpenicilloyl-polylysine: a preliminary study | journal = Allergy and Asthma Proceedings | volume = 25 | issue = 3 | pages = 165–168 | year = 2004 | pmid = 15317320 | name-list-style = vanc }}{{cite journal | vauthors = Goldschmidt BM, Levine BB | title = The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy | journal = The Journal of Antibiotics | volume = 36 | issue = 6 | pages = 709–714 | date = June 1983 | pmid = 6874593 | doi = 10.7164/antibiotics.36.709 | doi-access = free }}{{Cite web | url=https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=2fbcc40c-f102-4abe-bce5-a93de95874fe&type=display |title = PRE-PEN® (benzylpenicilloyl polylysine injection USP) Skin Test Antigen | work = DailyMed | publisher = U.S. National Library of Medicine }}