bleeding diathesis

Following are some complications of coagulopathies, some of them caused by their treatments:

While there are several possible causes, they generally result in excessive bleeding and a lack of clotting.{{citation needed|date=April 2022}}

Acquired causes of coagulopathy include anticoagulation with warfarin, liver failure, vitamin K deficiency and disseminated intravascular coagulation. Additionally, the hemotoxic venom from certain species of snakes can cause this condition, for example Bothrops, rattlesnakes and other species of viper. Viral hemorrhagic fevers include dengue hemorrhagic fever and dengue shock syndrome.

Leukemia may also cause coagulopathy. Furthermore, cystic fibrosis has been known to cause bleeding diathesis, especially in undiagnosed infants, due to malabsorption of fat soluble vitamins like vitamin K.{{citation needed|date=July 2020}}

There are autoimmune causes of coagulation disorders. They include acquired antibodies to coagulation factors, termed inhibitors of coagulation. The main inhibitor is directed against clotting factor VIII. Another example is antiphospholipid syndrome, an autoimmune, hypercoagulable state.{{citation needed|date=July 2020}}

Bleeding diathesis may also be caused by impaired wound healing (as in scurvy), or by thinning of the skin, such as in Cushing's syndrome.{{citation needed|date=November 2021}}

Some people lack genes that typically produce the protein coagulation factors that allow normal clotting. Various types of hemophilia and von Willebrand disease are the major genetic disorders associated with coagulopathy. Rare examples are Bernard–Soulier syndrome, Wiskott–Aldrich syndrome and Glanzmann's thrombasthenia. Gene therapy treatments may be a solution as they involve in the insertion of normal genes to replace defective genes causing for the genetic disorder. Gene therapy is a source of active research that hold promise for the future.{{cite journal | vauthors = McCain J | title = The future of gene therapy | journal = Biotechnology Healthcare | volume = 2 | issue = 3 | pages = 52–60 | date = June 2005 | pmid = 23393464 | pmc = 3564347 }}

Consult a hematologist and have regular blood check ups. Have an early diagnostic test for any blood disorders or blood diseases including hemophilia, hemorrhage, and sickle-cell anemia. Prothrombin time and partial thromboplastin time blood tests are useful to investigate the reason behind the excessive bleeding. The PT evaluates coagulation factors I, II, V, VII and X, while the PTT evaluates coagulation factors I, II, V, VIII, IX, X, XI and XII. The analysis of both tests thus helps to diagnose certain disorders.{{Cite web|url=https://www.walkinlab.com/prothrombintime-pt-winrandpartialthrombopla.html|title=Prothrombin Time (PT) w/INR and Partial Thromboplastin Time (PTT) Blood Test|website=Walk-In Lab|language=en|access-date=2018-09-17}}

Blood transfusion involves the transfer of plasma containing all the necessary coagulating factors (fibrinogen, prothrombin, thromboplastin) to help restore them and to improve the immune defense of the patient after excessive blood loss. Blood transfusion also caused the transfer of platelets that can work along with coagulating factors for blood clotting to commence.{{Cite web|url=https://iliveok.com/health/hemorrhagic-diathesis_109599i15942.html|title=Hemorrhagic diathesis: causes, symptoms, diagnosis, treatment {{!}} Competently about health on iLive|website=iliveok.com|access-date=2018-09-17}}

Different drugs can be prescribed depending on the type of disease. Vitamins (K, P and C) are essential in case of obstruction to walls of blood vessels. Also, vitamin K is required for the production of blood clotting factors, hence the injection of vitamin K (phytomenadione) is recommended to boost blood clotting.{{Cite news|url=https://www.netdoctor.co.uk/medicines/heart-blood/a25886/treatments-for-bleeding-disorders/|title=Treatments for bleeding disorders|date=2015-11-03|work=Netdoctor|access-date=2018-09-17|language=en-GB}}

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| DiseasesDB = 1442

| ICD10 = {{ICD10|D|69|9|d|65}}

| ICD9 = {{ICD9|287.9}}

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| MeshID = D006474

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{{Diseases of megakaryocytes|us=y}}

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Category:Bleeding

Category:Coagulopathies