bovine ephemeral fever

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BEFV forms a bullet- or cone-shaped virions that consist of a negative, single stranded RNA genome with a lipid envelope and 5 structural proteins. The envelope glycoprotein G contains type-specific and neutralizing antigenic sites. There has been recent evidence which demonstrated that BEFV induces apoptosis in several cell lines. It was however shown that apoptosis could be blocked by the caspase inhibitor (Z-VAD-fmk), indicating that BEFV induces caspase-dependent apoptosis in cultured cells.{{cn|date=November 2022}}

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The virus has been found in tropical and subtropical regions of Asia, Africa and through eastern Australia. It is not found in the Americas, or in Europe (except western parts of Turkey).{{cite journal|last1=Walker|first1=Peter J.|last2=Klement|first2=Eyal|title=Epidemiology and control of bovine ephemeral fever|journal=Veterinary Research|date=28 October 2015|volume=46|page=124|doi=10.1186/s13567-015-0262-4|pmid=26511615|pmc=4624662 |doi-access=free }}

The virus is transmitted by an insect vector. The particular species linked to the virus are the biting midges Culicoides oxystoma and C. nipponensis.{{cn|date=November 2022}}

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The characteristics of the disease are the sudden onset of fever, stiffness, lameness and nasal and ocular discharges. BEF often causes hypocalcaemia which in turn generates clinical signs such as depression, cessation of rumination, muscle tremors and constipation.{{cn|date=November 2022}}

Although the pathogenesis of the disease is complex it seems clear that the host inflammatory responses, mediated by the release of cytokines, are involved in the expression of the disease.{{cn|date=November 2022}}

The virus can be isolated from blood and can be identified by immunofluorescence and immunostaining. Rising levels of antibodies in two samples taken 2 to 4 weeks apart also indicate infection.{{cn|date=November 2022}}

Rest, and lack of stress, are important to aid recovery. Animals lying flat out on their side, unable to get up, should be rolled over several times each day to prevent loss of circulation and muscle damage. If the animal has signs of hypocalcemia, such as rumen stasis, then calcium borogluconate may be administered. Non-steroidal anti-inflammatory drugs can improve recovery. Rest is absolutely imperative, for a minimum of one week or death can still occur.{{citation needed|date=February 2017}}

A vaccine is available in Japan but is very expensive which limits its use. Movement regulations are in place in several countries.

Ultravac BEF (from Zoetis) - is a vaccine to prevent bovine ephemeral fever. The product is registered in Australia, Israel and Egypt.{{cn|date=November 2022}}

{{Reflist}}

• {{cite journal|author1=Hsieh, Y. C. |author2=Chen, S. H. |author3=Chou, C. C. |author4=Ting, L. J. |author5=Itakura, C. |author6=Wang, F. I. |year=2005 |title=Bovine Ephemeral Fever in Taiwan (2001-2002) |journal=Journal of Veterinary Medical Science |volume=67 |issue=4 |pages=411–416 |doi=10.1292/jvms.67.411 |pmid=15876792 |doi-access=free }}
• {{ cite journal |author1=Chang, C. J. |author2=Shih, W. L. |author3=Yu, F. L. |author4=Liao, M. H. |author5=Liu, H. J. | year = 2004 | title = Apoptosis Induced by Bovine Ephemeral Fever Virus | journal = Journal of Virological Methods | volume = 122 | issue = 2 | pages = 165–170 | doi = 10.1016/j.jviromet.2004.08.016 | pmid = 15542140 }}
• {{cite journal|author1=Hsieh, Y. C. |author2=Wang, S. Y. |author3=Lee, Y. F. |author4=Chen, S. H. |author5=Mak, P. O. |author6=Chu, C. Y. |year=2006 |title=DNA Sequence Analysis of Glycoprotein G Gene of Bovine Ephemeral Fever Virus and Development of a Double Oil Emulsion Vaccine against Bovine Ephemeral Fever |journal=Journal of Veterinary Medical Science |volume=68 |issue=6 |pages=543–548 |doi=10.1292/jvms.68.543 |pmid=16820709 |doi-access=free }}

• {{ cite web | title = Bovine Ephemeral Fever | url = https://en.wikivet.net/Bovine_Ephemeral_Fever | publisher = wikivet.net | accessdate = 2012-02-23 }}

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Category:Animal viral diseases

Ephemeral Fever

Category:Rhabdoviridae