caspase 7

Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.{{cite web | title = Entrez Gene: CASP7 caspase 7, apoptosis-related cysteine peptidase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=840}}

Caspase 7 has been shown to interact with:

• Caspase 8,{{cite journal | vauthors = Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES | title = Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 13430–7 | date = Apr 2002 | pmid = 11832478 | doi = 10.1074/jbc.M108029200 | doi-access = free }}{{cite journal | vauthors = Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES | title = Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 25 | pages = 14486–91 | date = Dec 1996 | pmid = 8962078 | pmc = 26159 | doi = 10.1073/pnas.93.25.14486| bibcode = 1996PNAS...9314486S | doi-access = free }}
• Survivin{{cite journal | vauthors = Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC | title = IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs | journal = Cancer Res. | volume = 58 | issue = 23 | pages = 5315–20 | date = Dec 1998 | pmid = 9850056 }}{{cite journal | vauthors = Shin S, Sung BJ, Cho YS, Kim HJ, Ha NC, Hwang JI, Chung CW, Jung YK, Oh BH | title = An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7 | journal = Biochemistry | volume = 40 | issue = 4 | pages = 1117–23 | date = Jan 2001 | pmid = 11170436 | doi = 10.1021/bi001603q}} and
• XIAP.{{cite journal | vauthors = Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS | title = Structural basis for the inhibition of caspase-3 by XIAP | journal = Cell | volume = 104 | issue = 5 | pages = 791–800 | date = Mar 2001 | pmid = 11257232 | doi = 10.1016/S0092-8674(01)00274-4| s2cid = 17915093 | doi-access = free }}{{cite journal | vauthors = Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC | title = The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases | journal = EMBO J. | volume = 16 | issue = 23 | pages = 6914–25 | date = Dec 1997 | pmid = 9384571 | pmc = 1170295 | doi = 10.1093/emboj/16.23.6914 }}{{cite journal | vauthors = Deveraux QL, Takahashi R, Salvesen GS, Reed JC | title = X-linked IAP is a direct inhibitor of cell-death proteases | journal = Nature | volume = 388 | issue = 6639 | pages = 300–4 | date = Jul 1997 | pmid = 9230442 | doi = 10.1038/40901 | bibcode = 1997Natur.388..300D | s2cid = 4395885 | doi-access = free }}{{cite journal | vauthors = Suzuki Y, Nakabayashi Y, Nakata K, Reed JC, Takahashi R | title = X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes | journal = J. Biol. Chem. | volume = 276 | issue = 29 | pages = 27058–63 | date = Jul 2001 | pmid = 11359776 | doi = 10.1074/jbc.M102415200 | doi-access = free }}

• The Proteolysis Map
• Caspase

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• {{cite journal | vauthors = Cohen GM | title = Caspases: the executioners of apoptosis | journal = Biochem. J. | volume = 326 | issue = Pt 1 | pages = 1–16 | year = 1997 | pmid = 9337844 | pmc = 1218630 | doi = 10.1042/bj3260001}}

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• The MEROPS online database for peptidases and their inhibitors: [https://archive.today/20121223074921/http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C14.004 C14.004]
• {{PDBe-KB2|P55210|Human Caspase-7}}

{{PDB Gallery|geneid=840}}

{{Cysteine proteases}}

{{Enzymes}}

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Category:EC 3.4.22

Category:Caspases

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