cloroqualone

{{short description|Chemical compound}}

{{cs1 config|name-list-style=vanc|display-authors=6}}

{{Drugbox

| Verifiedfields = changed

| verifiedrevid = 460044931

| IUPAC_name = 3-(2,6-Dichlorophenyl)-2-ethyl-4-quinazolinone

| image = Cloroqualone.svg

| width = 200

| tradename =

| pregnancy_category = ?

| legal_CA =

| legal_US =

| routes_of_administration = ?

| bioavailability = ?

| metabolism = ?

| elimination_half-life = ?

| excretion = ?

| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 25509-07-3

| ATC_prefix = none

| ATC_suffix =

| PubChem = 63338

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 2106114

| DrugBank_Ref = {{drugbankcite|changed|drugbank}}

| DrugBank = ?

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 57005

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 172D4Q6LOW

| C=16 | H=12 | Cl=2 | N=2 | O=1

| smiles = Clc3cccc(Cl)c3N/1C(=O)c2c(\N=C\1CC)cccc2

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C16H12Cl2N2O/c1-2-14-19-13-9-4-3-6-10(13)16(21)20(14)15-11(17)7-5-8-12(15)18/h3-9H,2H2,1H3

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = SONHVLIDLXLSOL-UHFFFAOYSA-N

| melting_point =

}}

Cloroqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone developed in the 1980s and marketed mainly in France and some other European countries. It has sedative and antitussive properties resulting from its agonist activity at the β subtype of the GABA_a receptor and sigma-1 receptor, and was sold either alone or in combination with other ingredients as a cough medicine. Cloroqualone has weaker sedative properties than methaqualone and was sold for its useful cough-suppressing effects, but was withdrawn from the French market in 1994 because of concerns about its potential for abuse and overdose.{{Cite web | work = PubChem |title=Cloroqualone |url=https://pubchem.ncbi.nlm.nih.gov/compound/63338 |access-date=2022-07-29 | publisher = U.S. National Library of Medicine |language=en}}{{cite book | vauthors = Elks J | title = The Dictionary of Drugs: Chemical Data | date = November 2014 | publisher = Springer US |isbn=978-1-4757-2085-3 | page = 304 }}{{cite book | vauthors = Martindale W, Reynolds JE |title=Martindale: The Extra Pharmacopoeia |date=1993 |publisher=The Pharmaceutical Press |location=London |isbn=978-0-85369-300-0 |page=745 |edition=30th}}