clortermine

{{Short description|Chemical compound}}

{{Drugbox

| Verifiedfields = changed

| verifiedrevid = 460045066

| IUPAC_name = 1-(2-chlorophenyl)-2-methylpropan-2-amine

| image = Clortermine.svg

| image_class = skin-invert-image

| tradename =

| pregnancy_category = ?

| legal_US = Schedule III

| legal_status = Rx-only

| routes_of_administration = Oral

| bioavailability =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 10389-73-8

| ATC_prefix = none

| ATC_suffix =

| PubChem = 25223

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank = DB01527

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 23558

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 4FA88HM3IX

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D03566

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 1697833

| C=10 | H=14 | Cl=1 | N=1

| smiles = Clc1ccccc1CC(N)(C)C

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C10H14ClN/c1-10(2,12)7-8-5-3-4-6-9(8)11/h3-6H,7,12H2,1-2H3

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = HXCXASJHZQXCKK-UHFFFAOYSA-N

| synonyms = 2-chloro-α,α-dimethylphenethylamine;
2-chloro-α-methylamphetamine;
2-chlorophentermine

}}

Clortermine (Voranil) was developed by Ciba in the 1960s{{ cite patent | country = US | status = patent | number = 3415937 | title = The Suppression of Appetite with 1-(o-Chlorophenyl)-2-Methyl-2-Propylamine }} and is an anorectic drug of the amphetamine class.{{cite book | vauthors = Triggle DJ | title = Dictionary of Pharmacological Agents | publisher = Chapman & Hall / CRC | location = Boca Raton | year = 1996 | isbn = 0-412-46630-9 }} It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,{{cite journal | vauthors = Sannerud CA, Brady JV, Griffiths RR | title = Self-injection in baboons of amphetamines and related designer drugs | journal = NIDA Research Monograph | volume = 94 | pages = 30–42 | year = 1989 | pmid = 2514366 }} and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent.{{Citation needed|date=April 2010}}