complement component 6
{{Short description|Protein found in humans}}
{{Infobox_gene}}
Complement component 6 is a protein that in humans is encoded by the C6 gene.{{cite web | title = Entrez Gene: complement component 6 C6 complement C6 (Homo sapiens (human)) Gene ID: 729 |date= 24 November 2020| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=729| access-date = 9 December 2020 |website=www.ncbi.nlm.nih.gov }}
Complement component 6 is a protein involved in the complement system. It is part of the membrane attack complex which can insert into the cell membrane and cause the cell to lyse.
References
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Further reading
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- {{cite journal |vauthors=Cerhan JR, Novak AJ, Fredericksen ZS |title=Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. |journal=Br. J. Haematol. |volume=145 |issue= 5 |pages= 614–23 |year= 2009 |pmid= 19344414 |doi= 10.1111/j.1365-2141.2009.07675.x |pmc=2820509|display-authors=etal}}
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- {{cite journal |vauthors=Talmud PJ, Drenos F, Shah S |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |journal=Am. J. Hum. Genet. |volume=85 |issue= 5 |pages= 628–42 |year= 2009 |pmid= 19913121 |doi= 10.1016/j.ajhg.2009.10.014 |pmc=2775832|display-authors=etal}}
- {{cite journal |author=Müller-Eberhard HJ |title=Molecular organization and function of the complement system. |journal=Annu. Rev. Biochem. |volume=57 |pages= 321–47 |year= 1988 |pmid= 3052276 |doi= 10.1146/annurev.bi.57.070188.001541 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
- {{cite journal |vauthors=Eid NA, Hussein AA, Elzein AM |title=Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. |journal=Malar. J. |volume=9 |pages= 119 |year= 2010 |pmid= 20459687 |doi= 10.1186/1475-2875-9-119 |pmc=2877684|display-authors=etal |doi-access=free }}
- {{cite journal |vauthors=Fosbrink M, Cudrici C, Tegla CA |title=Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells. |journal=Exp. Mol. Pathol. |volume=86 |issue= 2 |pages= 87–94 |year= 2009 |pmid= 19162005 |doi= 10.1016/j.yexmp.2008.12.005 |pmc=2699899|display-authors=etal}}
- {{cite journal |vauthors=Rajaraman P, Brenner AV, Neta G |title=Risk of meningioma and common variation in genes related to innate immunity. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=19 |issue= 5 |pages= 1356–61 |year= 2010 |pmid= 20406964 |doi= 10.1158/1055-9965.EPI-09-1151 |pmc=3169167|display-authors=etal}}
- {{cite journal |vauthors=Ennis S, Jomary C, Mullins R |title=Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. |journal=Lancet |volume=372 |issue= 9652 |pages= 1828–34 |year= 2008 |pmid= 18842294 |doi= 10.1016/S0140-6736(08)61348-3 |display-authors=etal|pmc=5983350 }}
- {{cite journal |vauthors=Soejima M, Tachida H, Tsuneoka M |title=Nucleotide sequence analyses of human complement 6 (C6) gene suggest balancing selection. |journal=Ann. Hum. Genet. |volume=69 |issue= Pt 3 |pages= 239–52 |year= 2005 |pmid= 15845028 |doi= 10.1046/j.1529-8817.2005.00165.x |display-authors=etal}}
- {{cite journal |vauthors=Bulla R, Bossi F, Agostinis C |title=Complement production by trophoblast cells at the feto-maternal interface. |journal=J. Reprod. Immunol. |volume=82 |issue= 2 |pages= 119–25 |year= 2009 |pmid= 19665237 |doi= 10.1016/j.jri.2009.06.124 |display-authors=etal}}
- {{cite journal |vauthors=Gancz D, Donin N, Fishelson Z |title=Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death. |journal=Mol. Immunol. |volume=47 |issue= 2–3 |pages= 310–7 |year= 2009 |pmid= 19864026 |doi= 10.1016/j.molimm.2009.09.016 |doi-access= free }}
- {{cite journal |vauthors=Parham KL, Roberts A, Thomas A |title=Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish family. |journal=Mol. Immunol. |volume=44 |issue= 10 |pages= 2756–60 |year= 2007 |pmid= 17257682 |doi= 10.1016/j.molimm.2006.11.022 |display-authors=etal}}
- {{cite journal |vauthors=Wu C, Ma MH, Brown KR |title=Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. |journal=Proteomics |volume=7 |issue= 11 |pages= 1775–85 |year= 2007 |pmid= 17474147 |doi= 10.1002/pmic.200601006 |s2cid=22474278 |display-authors=etal}}
- {{cite journal |vauthors=Bailey SD, Xie C, Do R |title=Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |journal=Diabetes Care |volume=33 |issue= 10 |pages= 2250–3 |year= 2010 |pmid= 20628086 |doi= 10.2337/dc10-0452 |pmc=2945168|display-authors=etal}}
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