condensation domain

{{Infobox protein family

| Symbol = Condensation

| Name = Condensation

| image = PDB 1l5a EBI.jpg

| width =

| caption = crystal structure of vibh, an nrps condensation enzyme

| Pfam = PF00668

| Pfam_clan = CL0149

| InterPro = IPR001242

| SMART =

| PROSITE =

| MEROPS =

| SCOP = 1l5a

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.{{cite journal |vauthors=Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA | title = Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain | journal = J. Biol. Chem. | volume = 273 | issue = 35 | pages = 22773–81 |date=August 1998 | pmid = 9712910 | doi = 10.1074/jbc.273.35.22773| doi-access = free }}