constrictive pericarditis

Signs and symptoms of constrictive pericarditis are consistent with the following: fatigue, swollen abdomen, difficulty breathing (dyspnea), swelling of legs and general weakness. Related conditions are bacterial pericarditis, pericarditis and pericarditis after a heart attack.

The cause of constrictive pericarditis in the developing world are idiopathic in origin, though likely infectious in nature. In regions where tuberculosis is common, it is the cause in a large portion of cases.{{Cite book |last=Dunn |first=Brian |url=https://books.google.com/books?id=ruhJv1tM-CUC&q=tuberculosis+causes+constrictive+pericarditis&pg=PA653 |title=Manual of cardiovascular medicine |date=2013 |publisher=Wolters Kluwer Health/Lippincott Williams & Wilkins |isbn=978-1-4511-3160-4 |edition=4th |location=Philadelphia |page=653 |access-date=21 September 2015 |archive-url=https://web.archive.org/web/20230112112139/https://books.google.com/books?id=ruhJv1tM-CUC&q=tuberculosis+causes+constrictive+pericarditis&pg=PA653 |archive-date=12 January 2023 |url-status=live}}

Causes of constrictive pericarditis include:

• Tuberculosis{{Cite web |title=Constritive pericarditis |url=http://emedicine.medscape.com/article/157096-overview#showall |url-status=live |archive-url=https://web.archive.org/web/20150905090646/http://emedicine.medscape.com/article/157096-overview#showall |archive-date=5 September 2015 |access-date=21 September 2015 |website=eMedicine |publisher=MedScape}}
• Incomplete drainage of purulent pericarditis
• Fungal and parasitic infections
• Chronic pericarditis
• Postviral pericarditis
• Postsurgical
• Following MI, post-myocardial infarction
• In association with pulmonary asbestos{{Cite book |last=Lloyd |first=Joseph |url=https://books.google.com/books?id=WSCRAAAAQBAJ&q=pulmonary+asbestos++constrictive+pericarditis&pg=PA718 |title=Mayo Clinic cardiology : concise textbook |date=2013 |publisher=Mayo Clinic Scientific Press/Oxford University Press |isbn=978-0-199915712 |edition=4th |location=Oxford |page=718 |access-date=21 September 2015 |archive-url=https://web.archive.org/web/20230112112139/https://books.google.com/books?id=WSCRAAAAQBAJ&q=pulmonary+asbestos++constrictive+pericarditis&pg=PA718 |archive-date=12 January 2023 |url-status=live}}

File:Constrictive pericarditis.jpg

The pathophysiological characteristics of constrictive pericarditis are due to a thickened, fibrotic pericardium that forms a non-compliant shell around the heart. This shell prevents the heart from expanding when blood enters it. As pressure on the heart increases, the stroke volume decreases as a result of a reduction in the diastolic expansion in the chambers. Yadav NK, Siddique MS. Constrictive Pericarditis. [Updated 2022 May 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459314/ {{Webarchive|url=https://web.archive.org/web/20240121054033/https://www.ncbi.nlm.nih.gov/books/NBK459314/ |date=2024-01-21 }} This results in significant respiratory variation in blood flow in the chambers of the heart.{{Cite book |last=Crouch |first=Michael A. |url=https://books.google.com/books?id=U5MZBgAAQBAJ&q=constrictive+pericarditis+mechanism&pg=PT388 |title=Cardiovascular pharmacotherapy : a point-of-care guide |date=2010 |publisher=American Society of Health-System Pharmacists |isbn=978-1-58528-215-9 |location=Bethesda, Md. |page=376 |access-date=21 September 2015 |archive-url=https://web.archive.org/web/20230112112203/https://books.google.com/books?id=U5MZBgAAQBAJ&q=constrictive+pericarditis+mechanism&pg=PT388 |archive-date=12 January 2023 |url-status=live}}

During inspiration, pressure in the thoracic cavity decreases but is not relayed to the left atrium, subsequently a reduction in flow to the left atrium and ventricle happens. During diastole, less blood flow in left ventricle allows for more room for filling in right ventricle and therefore a septal shift occurs.{{Cite book |last=Camm |first=Demosthenes G. Katritsis, Bernard J. Gersh, A. John |url=https://books.google.com/books?id=1ZjrAQAAQBAJ&q=constrictive+pericarditis+definition&pg=PA388 |title=Clinical cardiology : current practice guidelines |date=2013 |publisher=Oxford University Press |isbn=978-0-19-968528-8 |edition=1st |location=Oxford |page=388 |access-date=21 September 2015 |archive-url=https://web.archive.org/web/20230112112140/https://books.google.com/books?id=1ZjrAQAAQBAJ&q=constrictive+pericarditis+definition&pg=PA388 |archive-date=12 January 2023 |url-status=live}}

During expiration, the amount of blood entering the left ventricle will increase, allowing the interventricular septum to bulge towards the right ventricle, decreasing the right heart ventricular filing.

File:Tuberculosis-x-ray-1.jpg

The diagnosis of constrictive pericarditis is often difficult to make. In particular, restrictive cardiomyopathy has many similar clinical features to constrictive pericarditis, and differentiating them in a particular individual is often a diagnostic dilemma.{{Cite web |title=Restrictive pericarditis |url=http://emedicine.medscape.com/article/153062-differential |url-status=live |archive-url=https://web.archive.org/web/20150930050232/http://emedicine.medscape.com/article/153062-differential |archive-date=30 September 2015 |access-date=21 September 2015 |website=eMedicine |publisher=MedScape}}

• Chest X-Ray - pericardial calcification (common but not specific), pleural effusions are common findings.{{Cite web |title=Imaging in Constrictive pericarditis |url=http://emedicine.medscape.com/article/348883-overview |url-status=live |archive-url=https://web.archive.org/web/20150905100739/http://emedicine.medscape.com/article/348883-overview |archive-date=5 September 2015 |access-date=21 September 2015 |website=eMedicine |publisher=MedScape}}
• Echocardiography - the principal echographic finding is changes in cardiac chamber volume.
• CT and MRI - CT scan is useful in assessing the thickness of pericardium, calcification, and ventricular contour. Cardiac MRI may find pericardial thickening and pericardial-myocardial adherence. Ventricular septum shift during breathing can also be found using cardiac MRI. Late gadolinium enhancement can show enhancement of the pericardium due to fibroblast proliferation and neovascularization.{{Cite journal |last=Welch |first=Terrence D. |last2=Oh |first2=Jae K. |date=November 2017 |title=Constrictive Pericarditis |journal=Cardiology Clinics |language=en |volume=35 |issue=4 |pages=539–549 |doi=10.1016/j.ccl.2017.07.007 |pmid=29025545}}
• BNP blood test - tests for the existence of the cardiac hormone brain natriuretic peptide, which is only present in restrictive cardiomyopathy but not in constrictive pericarditis{{Cite book |last=Semrad |first=Michal |url=https://books.google.com/books?id=VaVxBgAAQBAJ&q=BNP+blood+test+constrictive+pericarditis&pg=PA114 |title=Cardiovascular Surgery |date=2014 |publisher=Charles University |isbn=978-80-246-2465-5 |page=114 |access-date=21 September 2015 |archive-url=https://web.archive.org/web/20230112112140/https://books.google.com/books?id=VaVxBgAAQBAJ&q=BNP+blood+test+constrictive+pericarditis&pg=PA114 |archive-date=12 January 2023 |url-status=live}}
• Conventional cardiac catheterization
• Physical examination - can reveal clinical features including Kussmaul's sign and a pericardial knock.{{Cite journal |last=Khandaker |first=Masud H. |last2=Espinosa |first2=Raul E. |last3=Nishimura |first3=Rick A. |last4=Sinak |first4=Lawrence J. |last5=Hayes |first5=Sharonne N. |last6=Melduni |first6=Rowlens M. |last7=Oh |first7=Jae K. |date=June 2010 |title=Pericardial Disease: Diagnosis and Management |journal=Mayo Clinic Proceedings |volume=85 |issue=6 |pages=572–593 |doi=10.4065/mcp.2010.0046 |pmc=2878263 |pmid=20511488}}

The definitive treatment for constrictive pericarditis is pericardial stripping, which is a surgical procedure where the entire pericardium is peeled away from the heart. This procedure has significant risk involved,{{Cite journal |vauthors=Cinar B, Enc Y, Goksel O, Cimen S, Ketenci B, Teskin O, Kutlu H, Eren E |year=2006 |title=Chronic constrictive tuberculous pericarditis: risk factors and outcome of pericardiectomy |journal=Int J Tuberc Lung Dis |volume=10 |issue=6 |pages=701–6 |pmid=16776460}} with mortality rates of 6% or higher in major referral centers.{{Cite journal |vauthors=Chowdhury UK, Subramaniam GK, Kumar AS, Airan B, Singh R, Talwar S, Seth S, Mishra PK, Pradeep KK, Sathia S, Venugopal P |year=2006 |title=Pericardiectomy for constrictive pericarditis: a clinical, echocardiographic, and hemodynamic evaluation of two surgical techniques |journal=Ann Thorac Surg |volume=81 |issue=2 |pages=522–9 |doi=10.1016/j.athoracsur.2005.08.009 |pmid=16427843 |doi-access=free}}

A poor outcome is almost always the result after a pericardiectomy is performed for constrictive pericarditis whose origin was radiation-induced, further some patients may develop heart failure post-operatively.{{Cite book |last=Greenberg |first=Barry H. |url=https://books.google.com/books?id=PV8A8282d2EC&q=constrictive+pericarditis+treatment&pg=PA410 |title=Congestive heart failure |date=2007 |publisher=Lippincott Williams & Wilkins |isbn=978-0-7817-6285-4 |edition=3rd |location=Philadelphia |page=410 |access-date=21 September 2015 |archive-url=https://web.archive.org/web/20230112112140/https://books.google.com/books?id=PV8A8282d2EC&q=constrictive+pericarditis+treatment&pg=PA410 |archive-date=12 January 2023 |url-status=live}}

{{Reflist}}

• {{Cite journal |last=Hoit |first=B. D. |date=25 June 2002 |title=Management of Effusive and Constrictive Pericardial Heart Disease |url=http://circ.ahajournals.org/content/105/25/2939.long |journal=Circulation |volume=105 |issue=25 |pages=2939–2942 |doi=10.1161/01.CIR.0000019421.07529.C5 |pmid=12081983 |access-date=21 September 2015 |doi-access=free}}

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{{Medical resources

| DiseasesDB =

| ICD10 = {{ICD10|I|31|1|i|30}}

| ICD9 = {{ICD9|423.2}}

| ICDO =

| OMIM =

| MedlinePlus = 001103

| eMedicineSubj = article

| eMedicineTopic = 157096

| eMedicine_mult =

| MeshID = D010494

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{{Heart diseases}}

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Category:Disorders of fascia

Category:Inflammations

Category:Pericardial disorders