copalyl diphosphate synthase

{{infobox enzyme

| Name = copalyl diphosphate synthase

| EC_number = 5.5.1.12

| CAS_number = 157972-08-2

| GO_code = 0050559

| image =

| width =

| caption =

}}

In enzymology, a copalyl diphosphate synthase ({{EnzExplorer|5.5.1.12}}) is an enzyme that catalyzes the chemical reaction

:geranylgeranyl diphosphate $\rightleftharpoons$ (+)-copalyl diphosphate

Hence, this enzyme has one substrate, geranylgeranyl diphosphate, and one product, (+)-copalyl diphosphate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is (+)-copalyl-diphosphate lyase (decyclizing). This enzyme participates in diterpenoid biosynthesis.

References

{{cite journal | author = RB | date = 2000 | title = Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme | journal = Biochemistry | volume = 39 | pages = 15592–602 | pmid = 11112547 | doi = 10.1021/bi001997l | last2 = Flory | first2 = JE | last3 = Jetter | first3 = R | last4 = Ravn | first4 = MM | last5 = Lee | first5 = HJ | last6 = Coates | first6 = RM | last7 = Croteau | first7 = RB | issue = 50 }}
{{cite journal | vauthors = Peters RJ, Ravn MM, Coates RM, Croteau RB | date = 2001 | title = Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites | journal = J. Am. Chem. Soc. | volume = 123 | pages = 8974–8 | pmid = 11552804 | doi = 10.1021/ja010670k | issue = 37 }}
{{cite journal | vauthors = Peters RJ, Croteau RB | date = 2002 | title = Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | pages = 580–4 | pmid = 11805316 | doi = 10.1073/pnas.022627099 | issue = 2 | pmc = 117348 | bibcode = 2002PNAS...99..580P | doi-access = free }}
{{cite journal | vauthors = Ravn MM, Peters RJ, Coates RM, Croteau R | date = 2002 | title = Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates | journal = J. Am. Chem. Soc. | volume = 124 | pages = 6998–7006 | pmid = 12059223 | doi = 10.1021/ja017734b | issue = 24 }}
{{cite journal | vauthors = Peters RJ, Croteau RB | date = 2002 | title = Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate | journal = Biochemistry | volume = 41 | pages = 1836–42 | pmid = 11827528 | doi = 10.1021/bi011879d | issue = 6 }}

Category:EC 5.5.1

Category:Enzymes of unknown structure