craniotabes
{{Short description|Softening or thinning of the skull in infants and children}}
{{Infobox medical condition (new)
| name = Craniotabes
| synonyms =
| image = Cranial bones en.svg
| alt =
| caption = Cranial bones
| pronounce =
| field = Pediatrics
| symptoms =
| complications =
| onset =
| duration =
| types =
| causes =
| risks =
| diagnosis =
| differential =
| prevention =
| treatment =
| medication =
| prognosis =
| frequency =
| deaths =
}}
Craniotabes is softening or thinning of the skull in infants and children, which may be normally present in newborns. It is seen mostly in the occipital and parietal bones. The bones are soft, and when pressure is applied they will collapse underneath it. When the pressure is relieved, the bones will usually snap back into place.{{cite journal|last1=Harvey|first1=Nicholas C.|last2=Holroyd|first2=Christopher|last3=Ntani|first3=Georgia|last4=Javaid|first4=Kassim|last5=Cooper|first5=Philip|last6=Moon|first6=Rebecca|last7=Cole|first7=Zoe|last8=Tinati|first8=Tannaze|last9=Godfrey|first9=Keith|last10=Dennison|first10=Elaine|author-link10=Elaine Dennison|last11=Bishop|first11=Nicholas J.|date=2014|title=Vitamin D supplementation in pregnancy: a systematic review|url=https://doi.org/10.3310%2Fhta18450|journal=Health Technology Assessment|volume=18|issue=45|pages=1–190|doi=10.3310/hta18450|issn=2046-4924|pmc=4124722|pmid=25025896|first12=Janis|last13=Cooper|first13=Cyrus|last12=Baird}}{{cite journal|last1=Prentice|first1=Ann|title=Nutritional rickets around the world|journal=The Journal of Steroid Biochemistry and Molecular Biology|date=July 2013|volume=136|pages=201–206|doi=10.1016/j.jsbmb.2012.11.018|pmid=23220549|s2cid=19944113}}
Causes
Any condition that affects bone growth, most notably rickets{{cite journal|last1=Elidrissy|first1=Abdelwahab T. H.|title=The Return of Congenital Rickets, Are We Missing Occult Cases?|journal=Calcified Tissue International|date=31 May 2016|volume=99|issue=3|pages=227–236|doi=10.1007/s00223-016-0146-2|pmid=27245342|s2cid=14727399}}{{cite journal|last1=Paterson|first1=Colin R.|last2=Ayoub|first2=David|title=Congenital rickets due to vitamin D deficiency in the mothers|journal=Clinical Nutrition|date=October 2015|volume=34|issue=5|pages=793–798|doi=10.1016/j.clnu.2014.12.006|pmid=25552383}} (from vitamin D deficiency),{{cite journal|last1=Ercan|first1=Makbule|title=Relationship between newborn craniotabes and vitamin D status|journal=Northern Clinics of Istanbul|volume=3|issue=1|pages=15–21|date=2016|doi=10.14744/nci.2016.48403|pmid=28058380|pmc=5175072}} marasmus, syphilis, or thalassemia, can cause craniotabes if present during a time of rapid skull growth (most especially during gestation and infancy). It can be a "normal" feature in premature infants. It is the first sign in children and infants with rickets.{{citation needed|date=May 2020}}
Other conditions which can cause craniotabes include hypervitaminosis A, osteogenesis imperfecta, hydrocephalus, and congenital syphilis.{{cite journal |last1=Yorifuji |first1=Junko |last2=Yorifuji |first2=Tohru |last3=Tachibana |first3=Kenji |last4=Nagai |first4=Shizuyo |last5=Kawai |first5=Masahiko |last6=Momoi |first6=Toru |last7=Nagasaka |first7=Hironori |last8=Hatayama |first8=Hiroshi |last9=Nakahata |first9=Tatsutoshi |title=Craniotabes in Normal Newborns: The Earliest Sign of Subclinical Vitamin D Deficiency |journal=The Journal of Clinical Endocrinology & Metabolism |date=1 May 2008 |volume=93 |issue=5 |pages=1784–1788 |doi=10.1210/jc.2007-2254 |pmid=18270256 |s2cid=20874233 |url=https://academic.oup.com/jcem/article/93/5/1784/2598780 |access-date=21 January 2023}}
Diagnosis
Physical examination{{citation needed|date=May 2020}}
The NIH recommends that this condition isn't tested for or treated in normal newborns because the condition is found in approximately 30% of otherwise normal newborns and can usually heal within 2-3 months.
However, recent evidence indicates that vitamin D deficiency in infants can increase the risk of asthma, lower respiratory tract infections, type 1 diabetes, schizophrenia, and decreased bone mass later in life.
Management
Management of craniotabes depends on the cause. The majority of craniotabes occurs in term infants and can be a normal finding.
Commonly, craniotabes results from the position of the head inside the uterus weeks prior to delivery. Calcium and Vitamin D levels should be obtained to rule out rickets, and in mothers who have prenatal labs concerning for T. pallidum infection, neonates should be evaluated for congenital syphilis.{{citation needed|date=June 2020}}
Etymology
The term (cranio- + tabes) is derived from the Latin words cranium for skull and tabes for wasting.https://en.wiktionary.org/wiki/craniotabes {{User-generated source|date=May 2022}}
References
{{reflist}}
External links
{{Medical resources
| DiseasesDB =
| ICD10 =
| ICD9 =
| ICDO =
| OMIM =
| MedlinePlus = 001591
| eMedicineSubj =
| eMedicineTopic =
| MeSH =
| GeneReviewsNBK =
| GeneReviewsName =
| SNOMED CT = 88034002
}}