de la Serna

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de la Serna is a surname. Notable people with the name include:

• Jacobo de la Serna (born 1965), American ceramic artist, Spanish Colonial scholar, and painter
• Jorge Juan Crespo de la Serna (1887–1978), Mexican artist, art critic and art historian
• José de la Serna e Hinojosa (1770–1832), Spanish general and Viceroy of Peru
• Juan Pérez de la Serna (1570–1631), seventh Archbishop of Mexico
• Pedro Gómez de la Serna (1806–1871), Spanish jurist and politician
• Ramón Gómez de la Serna (1888–1963), Spanish writer
• Rodrigo de la Serna (born 1976), Argentine actor