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dependoparvovirus

{{Short description|Genus of viruses}}

{{Use dmy dates|date=February 2020}}

{{Virusbox

| taxon = Dependoparvovirus

| image = File:Adeno-associated viruses.jpg

| subdivision_ranks = Species

| subdivision = See text

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Dependoparvovirus (formerly Dependovirus or Adeno-associated virus group) is a genus in the subfamily Parvovirinae of the virus family Parvoviridae;{{cite journal | last1 = Cotmore | first1 = SF | last2 = Agbandje-McKenna | first2 = M | last3 = Canuti | first3 = M | last4 = Chiorini | first4 = JA | last5 = Eis-Hubinger | first5 = A | last6 = Hughes | first6 = J | last7 = Mietzsch | first7 = M | last8 = Modha | first8 = S | last9 = Ogliastro | first9 = M | last10 = Pénzes | first10 = JJ | last11 = Pintel | first11 = DJ | last12 = Qiu | first12 = J | last13 = Soderlund-Venermo | first13 = M | last14 = Tattersall | first14 = P | last15 = Tijssen | first15 = P | last16 = and the ICTV Report Consortium | year = 2019 | title = ICTV Virus Taxonomy Profile: Parvoviridae | journal = Journal of General Virology | volume = 100 | issue = 3 | pages = 367–368 | doi = 10.1099/jgv.0.001212| pmid = 30672729| pmc = 6537627 }}{{cite web |title=ICTV 10th Report (2018) |url=https://ictv.global/report/chapter/parvoviridae/parvoviridae }} they are Group II viruses according to the Baltimore classification.

The name refers to the fact that all dependoviruses, except duck parvovirus and goose parvovirus,{{cite web |title=Dependoparvovirus ~ ViralZone |url=https://viralzone.expasy.org/226.html?outline=all_by_species |website=viralzone.expasy.org}}{{cite web |title=Genus: Dependoparvovirus {{!}} ICTV |url=https://ictv.global/report/chapter/parvoviridae/parvoviridae/dependoparvovirus |website=ictv.global}} cannot replicate productively in their host cell without the cell being coinfected by a helper virus such as an adenovirus, a herpesvirus, or a vaccinia virus.

Species

The genus contains the following species, listed by scientific name and followed by the exemplar virus of the species:{{cite web|title=Virus Taxonomy: 2024 Release|url=https://ictv.global/taxonomy|publisher=International Committee on Taxonomy of Viruses|access-date=26 March 2025}}{{cite web|title=Species List: Parvoviridae|url=https://ictv.global/report/chapter/parvoviridae/taxonomy/parvoviridae|publisher=International Committee on Taxonomy of Viruses|access-date=26 March 2025}}

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Virology

File:ParvoviridaeVirion.jpg

Dependoparvoviruses have an icosahedral shape, measure 22 nm and are composed of 60 wedge-shaped proteins (triangulation number = 1). Three proteins (VP1, VP2 and VP3) are present in each capsomere. Each capsid is made from 5 VP1, 5 VP2, and 50 VP3 proteins. The capsid does not have an envelope.

The genome is a single molecule of single stranded DNA with a length of 4.7 kilobases. It has only two open reading frames. The 3' open reading frame is the structural capsid protein, cap, which can be spliced to form two RNAs, one for virion protein 1 (VP1) and the other goes on to eventually make VP2 and VP3. The second gene, rep, can be spliced into four different, nonstructural, regulatory proteins that all aid in the genome replication. These proteins are named Rep 78, Rep68, Rep 52, and Rep 40 based on their molecular weight.

Due to inverted terminal repeats (ITRs) at each end of the genome, a T-shaped secondary structure is formed. The complementary areas leave a 3' hydroxyl group single stranded for the replication to begin. This 3' hydroxyl group is used as a primer for the leading strand synthesis. Both positive and negative sense strands of DNA are made. Double stranded intermediates are formed throughout the replication; this means the two strands, positive and negative sense, will be matched up.{{cite journal |author= Gonçalves, M|title=Adeno-associated virus: from defective virus to effective vector|journal= Virology Journal |volume=2 |issue=1 |pages=43–60 |year=2005 |pmid= 15877812|doi=10.1186/1743-422X-2-43 |pmc= 1131931 |doi-access=free }}{{cite web

| url = https://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/00.050.1.03.htm

| title = ICTVdB - The Universal Virus Database, version 4: Dependovirus

| access-date = 4 May 2009

| author = ICTVdB Management

| editor = Büchen- Osmond, C.

| year = 2006

| website =

| publisher = Columbia University, New York, US

| pages =

}}

Host range

These viruses are capable of replication within all vertebrates. They are only limited by the virus they must infect with, also known as the helper virus. These helper viruses are necessary for the replication of a dependoparvovirus. A common helper virus in humans is the adenovirus.{{Citation needed|date=February 2020}}

Gene therapy

{{main|Adeno-associated virus#Use in gene therapy}}

References

{{Reflist}}

External links

{{Commons category}}

  • [http://www.expasy.org/viralzone/all_by_species/226.html ViralZone: Dependoparvovirus]

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Category:Parvovirinae

Category:Virus genera