destrin

{{Short description|Protein found in humans}}

{{infobox protein

| Name = Destrin (actin binding protein)

| caption = Nuclear magnetic resonance determined configuration of the tertiary structure of Destrin.{{PDB|1AK6}}; {{cite journal | vauthors = Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F | title = Tertiary structure of destrin and structural similarity between two actin-regulating protein families | journal = Cell | volume = 85 | issue = 7 | pages = 1047–55 |date=June 1996 | pmid = 8674111 | doi = 10.1016/S0092-8674(00)81305-7 | s2cid = 11470231 | doi-access = free }}

| image = Destrin.png

| width =

| HGNCid = 15750

| Symbol = DSTN

| AltSymbols = ADF

| EntrezGene = 11034

| OMIM = 609114

| RefSeq = NM_006870

| UniProt = P60981

| PDB =

| ECnumber =

| Chromosome = 20

| Arm = p

| Band = 12.1

| LocusSupplementaryData =

}}

Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the DSTN gene.{{cite web | title = Entrez Gene: Destrin | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11034 }}{{cite journal | vauthors = Hawkins M, Pope B, Maciver SK, Weeds AG | title = Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments | journal = Biochemistry | volume = 32 | issue = 38 | pages = 9985–93 |date=September 1993 | pmid = 8399167 | doi = 10.1021/bi00089a014}}{{cite journal | vauthors = Deloukas P, Matthews LH, Ashurst J | title = The DNA sequence and comparative analysis of human chromosome 20 | journal = Nature | volume = 414 | issue = 6866 | pages = 865–71 | year = 2001 | pmid = 11780052 | doi = 10.1038/414865a | bibcode = 2001Natur.414..865D |display-authors=etal| doi-access = free }} Destrin is a component protein in microfilaments.

The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.