dimethyl pimelimidate

{{chembox

| Name = Dimethyl pimelimidate

| ImageFile = Dimethyl pimelimidate.png

| ImageFile1 = Dimethyl-pimelimidate-3D-balls.png

| PIN = Dimethyl heptanediimidate

| OtherNames = Pimelimidic acid dimethyl ester dihydrochloride,
dimethyl heptane-1,7-diimidate dihydrochloride

| Section1 = {{Chembox Identifiers

| SMILES = COC(=N)CCCCCC(=N)OC

| CASNo = 36875-25-9

| CASNo2 = 58537-94-3

| CASNo2_Comment = (dihydrochloride)

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = L9U23Y3EV3

| PubChem = 65403

| ChemSpiderID=16742681

}}

| Section2 = {{Chembox Properties

| C=9|H=18|N=2|O=2

| Appearance = White crystalline powder (dihydrochloride)

| Solubility = Slightly soluble (dihydrochloride)

| MeltingPtC = 122

| MeltingPt_notes = dihydrochloride

}}

| Section4 = {{Chembox Thermochemistry

}}

| Section7 = {{Chembox Hazards

| NFPA-H = 1

| NFPA-F = 1

| NFPA-R = 0

| FlashPt = Not determined

}}

}}

Dimethyl pimelimidate (DMP) is an organic chemical compound with two functional imidate groups. It is usually available as the more stable dihydrochloride salt. It binds free amino groups at pH range 7.0-10.0 to form amidine bonds.

Uses

DMP is used mainly as bifunctional coupling reagent to link proteins. It is often used to prepare antibody affinity columns. The appropriate antibody is first incubated with Protein A or Protein G-agarose and allowed to bind. DMP is then added to couple the molecules together.

Health effects

DMP is irritating to the eyes, skin, mucous membranes and upper respiratory tract. It can exert harmful effects by inhalation, ingestion, or skin absorption.

References

  • [http://www.mpbio.com/includes/msds/ansi/en/150945-en-ansi.pdf MSDS safety data], also available in [http://www.mpbio.com/product_info.php?cPath=491_1_12&products_id=150945&processTab=technical other languages]{{Dead link|date=July 2019 |bot=InternetArchiveBot |fix-attempted=yes }}
  • [http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/D8388 Sigma-Aldrich product detail]
  • [https://web.archive.org/web/20061119062130/http://www.technochemical.com/msds/EN0118.pdf MSDS datasheet]

Category:Carboximidates