domestication syndrome

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Charles Darwin's study of The Variation of Animals and Plants Under Domestication in 1868 identified various behavioral, morphological, and physiological traits that are shared by domestic animals, but not by their wild ancestors. These shared traits became known as "the domestication syndrome", a term originally used to describe common changes in domesticated grains.{{Cite journal |last1=Harlan |first1=Jack R. |last2=de Wet |first2=J. M. J. |last3=Price |first3=E. Glen |date=1973 |title=Comparative Evolution of Cereals |url=https://www.jstor.org/stable/2406971 |journal=Evolution |volume=27 |issue=2 |pages=311–325 |doi=10.2307/2406971|jstor=2406971 |pmid=28564784 }}{{Cite journal |last=Hammer |first=Karl |date=June 1984 |title=Das Domestikationssyndrom |url=http://link.springer.com/10.1007/BF02098682 |journal=Die Kulturpflanze |language=de |volume=32 |issue=1 |pages=11–34 |doi=10.1007/BF02098682 |s2cid=42389667 |issn=0075-7209}} In animals, these traits include tameness, docility, floppy ears, altered tails, novel coat colors and patterns, reduced brain size, reduced body mass and smaller teeth.{{Cite journal |last1=Sánchez-Villagra |first1=Marcelo R. |last2=Geiger |first2=Madeleine |last3=Schneider |first3=Richard A. |date=June 2016 |title=The taming of the neural crest: a developmental perspective on the origins of morphological covariation in domesticated mammals |journal=Royal Society Open Science |language=en |volume=3 |issue=6 |pages=160107 |doi=10.1098/rsos.160107 |issn=2054-5703 |pmc=4929905 |pmid=27429770|bibcode=2016RSOS....360107S }} Other traits include changes in craniofacial morphology, alterations to the endocrine system, and changes to the female estrous cycles including the ability to breed all year-round.

A recent hypothesis suggests that neural crest cell behaviour may be modified by domestication, which then leads to those traits that are common across many domesticated animal species.{{Cite journal |last=Wilkins |first=Adam S. |date=January 2020 |title=A striking example of developmental bias in an evolutionary process: The "domestication syndrome" |url=https://onlinelibrary.wiley.com/doi/10.1111/ede.12319 |journal=Evolution & Development |language=en |volume=22 |issue=1–2 |pages=143–153 |doi=10.1111/ede.12319 |pmid=31545016 |issn=1520-541X}}{{Cite journal |last1=Wilkins |first1=Adam S |last2=Wrangham |first2=Richard |last3=Fitch |first3=W Tecumseh |date=2021-08-26 |editor-last=Peichel |editor-first=C L |title=The neural crest/domestication syndrome hypothesis, explained: reply to Johnsson, Henriksen, and Wright |url=https://academic.oup.com/genetics/article/doi/10.1093/genetics/iyab098/6323656 |journal=Genetics |language=en |volume=219 |issue=1 |doi=10.1093/genetics/iyab098 |issn=1943-2631 |pmc=8633094 |pmid=34849912}} This hypothesis has claimed support from many gene-based studies; e.g.,{{Cite journal |last1=Librado |first1=Pablo |last2=Gamba |first2=Cristina |last3=Gaunitz |first3=Charleen |last4=Der Sarkissian |first4=Clio |last5=Pruvost |first5=Mélanie |last6=Albrechtsen |first6=Anders |last7=Fages |first7=Antoine |last8=Khan |first8=Naveed |last9=Schubert |first9=Mikkel |last10=Jagannathan |first10=Vidhya |last11=Serres-Armero |first11=Aitor |last12=Kuderna |first12=Lukas F. K. |last13=Povolotskaya |first13=Inna S. |last14=Seguin-Orlando |first14=Andaine |last15=Lepetz |first15=Sébastien |date=2017-04-28 |title=Ancient genomic changes associated with domestication of the horse |url=https://www.science.org/doi/10.1126/science.aam5298 |journal=Science |language=en |volume=356 |issue=6336 |pages=442–445 |doi=10.1126/science.aam5298 |pmid=28450643 |bibcode=2017Sci...356..442L |s2cid=206656021 |issn=0036-8075}}{{Cite journal |last1=Pendleton |first1=Amanda L. |last2=Shen |first2=Feichen |last3=Taravella |first3=Angela M. |last4=Emery |first4=Sarah |last5=Veeramah |first5=Krishna R. |last6=Boyko |first6=Adam R. |last7=Kidd |first7=Jeffrey M. |date=December 2018 |title=Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication |journal=BMC Biology |language=en |volume=16 |issue=1 |page=64 |doi=10.1186/s12915-018-0535-2 |doi-access=free |issn=1741-7007 |pmc=6022502 |pmid=29950181}} However, recent publications have disputed this support; pointing out that observed change in neural crest related genes only reveals change in neural crest-derived features. In effect, it is not evidence of linked trait changes in different species due to pleiotropic neural crest mechanisms as claimed by the neural crest cell hypothesis. For example, all of the craniofacial skeleton is derived from the neural crest, so any animal population that experiences evolutionary change in craniofacial features will show changes in genes associated with the neural crest. The number and importance of neural crest cell features in all vertebrates means change in these features is almost inevitable under the major selective regime shifts experienced by animals making the wild to domestic transition.

Many similar traits – both in animals and plants – are produced by orthologs; however, whether this is true for domestication traits or merely for wild forms is less clear. Especially in the case of plant crops, doubt has been cast because some domestication traits have been found to result from unrelated loci.

In 2018, a study identified 429 genes that differed between modern dogs and modern wolves. As the differences in these genes could also be found in ancient dog fossils, these were regarded as being the result of the initial domestication and not from recent breed formation. These genes are linked to neural crest and central nervous system development. These genes affect embryogenesis and can confer tameness, smaller jaws, floppy ears, and diminished craniofacial development, which distinguish domesticated dogs from wolves and are considered to reflect domestication syndrome. The study concluded that during early dog domestication, the initial selection was for behavior. This trait is influenced by those genes which act in the neural crest, which led to the phenotypes observed in modern dogs.

The 2023 parasite-mediated domestication hypothesis suggests that endoparasites such as helminths and protozoa could have mediated the domestication of mammals. Domestication involves taming, which has an endocrine component; and parasites can modify endocrine activity and microRNAs. Genes for resistance to parasites might be linked to those for the domestication syndrome; it is predicted that domestic animals are less resistant to parasites than their wild relatives.{{cite journal |last=Skok |first=J. |date=2023a |title=The Parasite-Mediated Domestication Hypothesis |journal=Agricultura Scientia |doi=10.18690/agricsci.20.1.1 |volume=20 |issue=1 |pages=1–7 |doi-access=free}}{{Cite journal |last=Skok|first=J. |date=2023b |title=Addendum to "The parasite-mediated domestication hypothesis" |journal=OSF |doi=10.31219/osf.io/f92aj |doi-access=free}}

A dog's cranium is 15% smaller than an equally heavy wolf's, and the dog is less aggressive and more playful. Other species pairs show similar differences. Bonobos, like chimpanzees, are a close genetic cousin to humans, but unlike the chimpanzees, bonobos are not aggressive and do not participate in lethal inter-group aggression or kill within their own group. The most distinctive features of a bonobo are its cranium, which is 15% smaller than a chimpanzee's, and its less aggressive and more playful behavior. These, and other, features led to the proposal that bonobos are a 'self-domesticated' ape.{{Cite journal |last1=Hare |first1=Brian |last2=Wobber |first2=Victoria |last3=Wrangham |first3=Richard |date=March 2012 |title=The self-domestication hypothesis: evolution of bonobo psychology is due to selection against aggression |url=https://linkinghub.elsevier.com/retrieve/pii/S000334721100546X |journal=Animal Behaviour |language=en |volume=83 |issue=3 |pages=573–585 |doi=10.1016/j.anbehav.2011.12.007|s2cid=3415520 }} In other examples, the guinea pig's cranium is 13% smaller than its wild cousin the cavy, and domestic fowl show a similar reduction to their wild cousins. In a famous Russian farm fox experiment, foxes selectively bred for reduced aggression appeared to show other traits associated with domestication syndrome. This prompted the claim that domestication syndrome was caused by selection for tameness. The foxes were not selectively bred for smaller craniums and teeth, floppy ears, or skills at using human gestures, but these traits were demonstrated in the friendly foxes. Natural selection favors those that are the most successful at reproducing, not the most aggressive. Selection against aggression made possible the ability to cooperate and communicate among foxes, dogs and bonobos.{{rp|114}} The more docile animals have been found to have less testosterone than their more aggressive counterparts, and testosterone controls aggression and brain size. The further away a dog breed is genetically from wolves, the larger the relative brain size is.[https://phys.org/news/2023-05-brains-modern-dog-larger-ancient.html Study finds the brains of modern dog breeds are larger than those of ancient breeds]

The domestication syndrome was reported to have appeared in the domesticated silver fox cultivated by Dmitry Belyayev's breeding experiment. However, in 2015 canine researcher Raymond Coppinger found historical evidence that Belyayev's foxes originated in fox farms on Prince Edward Island and had been bred there for fur farming since the 1800s, and that the traits demonstrated by Belyayev had occurred in the foxes prior to the breeding experiment.{{Cite news |last=Gorman |first=James |date=2019-12-03 |title=Why Are These Foxes Tame? Maybe They Weren't So Wild to Begin With |work=The New York Times |url=https://www.nytimes.com/2019/12/03/science/foxes-tame-belyaev.html |access-date=2020-11-18}} A 2019 opinion paper by Lord and colleagues argued that the results of the "Russian farm fox experiment" were overstated, although the pre-domesticated origins of these Russian foxes were already a matter of scientific record.{{Cite journal |last1=Statham |first1=Mark J. |last2=Trut |first2=Lyudmila N. |last3=Sacks |first3=Ben N. |last4=Kharlamova |first4=Anastasiya V. |last5=Oskina |first5=Irina N. |last6=Gulevich |first6=Rimma G. |last7=Johnson |first7=Jennifer L. |last8=Temnykh |first8=Svetlana V. |last9=Acland |first9=Gregory M. |last10=Kukekova |first10=Anna V. |date=May 2011 |title=On the origin of a domesticated species: identifying the parent population of Russian silver foxes (Vulpes vulpes): THE ORIGIN OF RUSSIAN SILVER FOXES |journal=Biological Journal of the Linnean Society |language=en |volume=103 |issue=1 |pages=168–175 |doi=10.1111/j.1095-8312.2011.01629.x |pmc=3101803 |pmid=21625363}}

In 2020, Wright et al.{{Cite journal |last1=Wright |first1=Dominic |last2=Henriksen |first2=Rie |last3=Johnsson |first3=Martin |date=December 2020 |title=Defining the Domestication Syndrome: Comment on Lord et al. 2020 |url=https://linkinghub.elsevier.com/retrieve/pii/S016953472030224X |journal=Trends in Ecology & Evolution |language=en |volume=35 |issue=12 |pages=1059–1060 |doi=10.1016/j.tree.2020.08.009|pmid=32917395 |bibcode=2020TEcoE..35.1059W |s2cid=221636622 }} argued Lord et al.'s critique refuted only a narrow and unrealistic definition of domestication syndrome because their criteria assumed it must be caused by genetic pleiotropy, and arises in response to 'selection for tameness'--as was claimed by Belyaev,{{Cite journal |url=https://academic.oup.com/jhered/article/70/5/301/813519 |access-date=2024-03-05 |journal=Journal of Heredity|doi=10.1093/oxfordjournals.jhered.a109263 |title=Destabilizing selection as a factor in domestication |date=1979 |last1=Belyaev |first1=D. K. |volume=70 |issue=5 |pages=301–308 |pmid=528781 }} Trut,{{Cite journal |last=Trut |first=Lyudmila |date=1999 |title=Early Canid Domestication: The Farm-Fox Experiment |url=http://www.americanscientist.org/issues/feature/1999/2/early-canid-domestication-the-farm-fox-experiment |journal=American Scientist |language=en |volume=87 |issue=2 |pages=160 |doi=10.1511/1999.2.160 |issn=0003-0996 |archive-date=2017-04-01 |access-date=2024-03-05 |archive-url=https://web.archive.org/web/20170401042436/http://www.americanscientist.org/issues/feature/1999/2/early-canid-domestication-the-farm-fox-experiment |url-status=dead }} and the proposers of the neural crest hypothesis. In the same year, Zeder{{Cite journal |last=Zeder |first=Melinda A. |date=August 2020 |title=Straw Foxes: Domestication Syndrome Evaluation Comes Up Short |url=https://linkinghub.elsevier.com/retrieve/pii/S0169534720300756 |journal=Trends in Ecology & Evolution |language=en |volume=35 |issue=8 |pages=647–649 |doi=10.1016/j.tree.2020.03.001|pmid=32668211 |bibcode=2020TEcoE..35..647Z |s2cid=216513400 }} pointed out that it makes no sense to deny the existence of domestication syndrome on the basis that domestication syndrome traits were present in the pre-domesticated founding foxes.

The hypothesis that neural crest genes underlie some of the phenotypic differences between domestic and wild horses and dogs is supported by the functional enrichment of candidate genes under selection. But, the observation of changed neural crest cell genes between wild and domestic populations need only reveal changes to features derived from neural crest, it does not support the claim of a common underlying genetic architecture that causes all of the domestication syndrome traits in all of the different animal species.

Gleeson and Wilson synthesised this debate and showed that animal domestication syndrome is not caused by selection for tameness, or by neural crest cell genetic pleiotropy. However, it could result from shared selective regime changes (which they termed 'reproductive disruption') leading to similarly shared trait changes across different species--in effect, a series of partial trait convergences. They proposed four primary selective pathways that are commonly altered by the shift to a domestic selective context, and would often lead to similar shifts in different populations. These pathways are:

1. Disrupted inter-sexual selection in males (reduced/altered female choice).
2. Disrupted intra-sexual selection in males (reduced/altered male-male competition).
3. Changed resource availability and predation pressure affecting female fertility and offspring survival.
4. Intensified potential for maternal stress, selecting for altered reproductive physiology in females.

Because the 'Reproductive Disruption' hypothesis explains domestication syndrome as a result of changed selective regimes, it can encompass multiple genetic or physiological ways that similar traits might emerge in the different domesticated species. For example, tamer behaviour might be caused by reduced adrenal reactivity,{{Cite journal |last1=Fallahsharoudi |first1=Amir |last2=de Kock |first2=Neil |last3=Johnsson |first3=Martin |last4=Ubhayasekera |first4=S. J. Kumari A. |last5=Bergquist |first5=Jonas |last6=Wright |first6=Dominic |last7=Jensen |first7=Per |date=2015-10-16 |title=Domestication Effects on Stress Induced Steroid Secretion and Adrenal Gene Expression in Chickens |journal=Scientific Reports |language=en |volume=5 |issue=1 |page=15345 |doi=10.1038/srep15345 |issn=2045-2322 |pmc=4608001 |pmid=26471470|bibcode=2015NatSR...515345F }} by increased oxytocin production,{{Cite journal |last1=Herbeck |first1=Yu. E. |last2=Gulevich |first2=R. G. |last3=Shepeleva |first3=D. V. |last4=Grinevich |first4=V. V. |date=May 2017 |title=Oxytocin: Coevolution of human and domesticated animals |url=http://link.springer.com/10.1134/S2079059717030042 |journal=Russian Journal of Genetics: Applied Research |language=en |volume=7 |issue=3 |pages=235–242 |doi=10.1134/S2079059717030042 |s2cid=21631875 |issn=2079-0597}} or by a combination of these or other mechanisms, across the different populations and species.

The same concept appears in the plant domestication process which produces crops, but with its own set of syndrome traits. In cereals, these include little to no shattering/fruit abscission, shorter height (thus decreased lodging), larger grain or fruit size, easier threshing, synchronous flowering, altered timing of flowering, increased grain weight, glutinousness (stickiness, not gluten protein content),{{cite journal | last1=Lenser | first1=Teresa | last2=Theißen | first2=Günter | title=Molecular mechanisms involved in convergent crop domestication | journal=Trends in Plant Science | publisher=Cell Press | volume=18 | issue=12 | year=2013 | issn=1360-1385 | doi=10.1016/j.tplants.2013.08.007 | pages=704–714 | pmid=24035234| bibcode=2013TPS....18..704L }} increased fruit/grain number, altered color compounds, taste, and texture, daylength independence, determinate growth, lesser/no vernalization, less seed dormancy.

Control of the syndrome traits in cereals is by:

; Shattering

• SH1 in sorghum, rice, and maize/corn
• sh4 in the rachis of rice{{cite journal | last1=Chen | first1=Erwang | last2=Huang | first2=Xuehui | last3=Tian | first3=Zhixi | last4=Wing | first4=Rod A. | last5=Han | first5=Bin | title=The Genomics of Oryza Species Provides Insights into Rice Domestication and Heterosis | journal=Annual Review of Plant Biology | publisher=Annual Reviews | volume=70 | issue=1 | date=2019-04-29 | issn=1543-5008 | doi=10.1146/annurev-arplant-050718-100320 | pages=639–665| pmid=31035826 | bibcode=2019AnRPB..70..639C | s2cid=140266038 }}
• qPDH1 in soybean
• Q in wheat
• LG1 in rice

; Plant height

• Rht-B1/Rht-D1 (two orthologous versions of Rht-1 on different subgenomes, Rht standing for reduced height) in wheat{{cite journal |last1=Pearce |first1=Stephen |last2=Saville |first2=Robert |last3=Vaughan |first3=Simon P. |last4=Chandler |first4=Peter M. |last5=Wilhelm |first5=Edward P. |last6=Sparks |first6=Caroline A. |last7=Al-Kaff |first7=Nadia |last8=Korolev |first8=Andrey |last9=Boulton |first9=Margaret I. |last10=Phillips |first10=Andrew L. |last11=Hedden |first11=Peter |last12=Nicholson |first12=Paul |last13=Thomas |first13=Stephen G. |title=Molecular Characterization of Rht-1 Dwarfing Genes in Hexaploid Wheat |journal=Plant Physiology |date=1 December 2011 |volume=157 |issue=4 |pages=1820–1831 |doi=10.1104/pp.111.183657 |pmid=22013218 |doi-access=free|pmc=3327217 }}
• ''GA20ox-2 in rice and barley
• KO2 in one Japanese cultivar of rice
• either dw3 or d2 in sorghum and pearl millet
• Ghd7 in rice
• Q in wheat

;Grain size

• GS3 in maize/corn and rice
• GS5 in rice
• An-1 in rice
• GAD1/RAE2 (smaller) in rice

; Yield

• SPL14/LOC4345998 in rice.{{cite journal |last1=Stange |first1=Madlen |last2=Barrett |first2=Rowan D. H. |last3=Hendry |first3=Andrew P. |title=The importance of genomic variation for biodiversity, ecosystems and people |journal=Nature Reviews Genetics |publisher=Nature Portfolio |volume=22 |issue=2 |date=February 2021 |issn=1471-0056 |doi=10.1038/s41576-020-00288-7 |pages=89–105 |pmid=33067582 |s2cid=223559538}}
• pyl1, pyl4, pyl6 in the PYL gene family in rice

; Threshability

• Q and Nud
• An-1 (by reducing or eliminating awns) in rice
• An-2/LABA1 - small awn reduction/barbless awns - in rice
• GAD1/RAE2 - awn elimination in rice
• tga1 - naked kernels in maize

; Flowering time

• VRN1 in barley, wheat, ryegrass

; Grain weight

• GW2 in rice, wheat, maize/corn
• GW5 in rice
• GLW2 in rice
• GASR7 in wheat
• GW5 in rice
• TGW6 in rice

; Glutinousness

• GBSSI or Waxy in rice{{cite journal | last1=Chen | first1=Kunling | last2=Wang | first2=Yanpeng | last3=Zhang | first3=Rui | last4=Zhang | first4=Huawei | last5=Gao | first5=Caixia | title=CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture | journal=Annual Review of Plant Biology | publisher=Annual Reviews | volume=70 | issue=1 | date=2019-04-29 | issn=1543-5008 | doi=10.1146/annurev-arplant-050718-100049 | pages=667–697| pmid=30835493 | s2cid=73471425 | doi-access=free | bibcode=2019AnRPB..70..667C }} (especially glutinous rice), wheat, corn, barley, sorghum, foxtail millet{{cite journal | last1=Purugganan | first1=Michael D. | last2=Fuller | first2=Dorian Q. | title=The nature of selection during plant domestication | journal=Nature | publisher=Nature Research | volume=457 | issue=7231 | year=2009 | issn=0028-0836 | doi=10.1038/nature07895 | pages=843–848| pmid=19212403 | bibcode=2009Natur.457..843P | s2cid=205216444 }}
• SBEIIb in rice

; Determinate growth

• TERMINAL FLOWER 1/TFL1 in Arabidopsis thaliana and orthologs
• Specifically, four orthologs in Glycine max and eight in Phaseolus vulgaris

; Standability

• PROSTRATE GROWTH/Prog1/PROG1 in rice
• teosinte branched1/tb1 (apical dominance) in maize/corn

; Grain/fruit number

• An-1 in rice
• GAD1/RAE2 in rice
• PROG1 (by increasing tiller number) in rice
• Gn1a in rice
• AAP3 (by increasing tiller number) in rice

; Panicle size

• DEP1 in rice and wheat

; Spike number

• vrs1 in barley

; Fragrance

• BADH2 produces 2-Acetyl-1-pyrroline when defective in rice; can be artificially disrupted to produce the same compound

; Delayed sprouting

• pyl1, pyl4, pyl6 in the PYL gene family - reduced preharvest sprouting in rice

; Altered color

• Rc - white pericarp in rice

; Unspecified trait

• Teosinte glume architecture/tga in maize/corn

Many of these are mutations in regulatory genes, especially transcription factors, which is likely why they work so well in domestication: They are not new, and are relatively ready to have their magnitudes altered. In annual grains, loss of function and altered expression are by far the most common, and thus are the most interesting goals of mutation breeding, while copy number variation and chromosomal rearrangements are far less common.

• Agricultural weed syndrome

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Category:Domestication

Category:Genetics

Category:Agriculture