eIF4B

eIF4B has been shown to interact with and stimulate the activity of eIF4A and bind to the eIF3 complex through the eIF3A subunit.{{cite journal | vauthors = Merrick WC | title = eIF4F: a retrospective | journal = The Journal of Biological Chemistry | volume = 290 | issue = 40 | pages = 24091–9 | date = Oct 2015 | pmid = 26324716 | doi = 10.1074/jbc.R115.675280 | pmc = 4591800 | doi-access = free }} This interaction results in the recruitment of the eukaryotic small ribosomal subunit (40S) to the mRNA which will in turn set the stage for the later steps leading to elongation.

• Eukaryotic translation
• eIF4F

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = van Heugten HA, Kasperaitis MA, Thomas AA, Voorma HO | title = Evidence that eukaryotic initiation factor (eIF) 2 is a cap-binding protein that stimulates cap recognition by eIF-4B and eIF-4F | journal = J. Biol. Chem. | volume = 266 | issue = 11 | pages = 7279–84 | year = 1991 | doi = 10.1016/S0021-9258(20)89641-0 | pmid = 2016328 | doi-access = free }}
• {{cite journal | vauthors = Milburn SC, Hershey JW, Davies MV, Kelleher K, Kaufman RJ | title = Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif | journal = EMBO J. | volume = 9 | issue = 9 | pages = 2783–90 | year = 1990 | pmid = 2390971 | pmc = 551988 | doi = 10.1002/j.1460-2075.1990.tb07466.x}}
• {{cite journal | vauthors = Howe JG, Hershey JW | title = Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells | journal = Cell | volume = 37 | issue = 1 | pages = 85–93 | year = 1984 | pmid = 6722878 | doi = 10.1016/0092-8674(84)90303-9 | doi-access = free }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Méthot N, Pause A, Hershey JW, Sonenberg N | title = The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence | journal = Mol. Cell. Biol. | volume = 14 | issue = 4 | pages = 2307–16 | year = 1994 | pmid = 8139536 | pmc = 358597 | doi = 10.1128/mcb.14.4.2307 }}
• {{cite journal | vauthors = Naranda T, Strong WB, Menaya J, Fabbri BJ, Hershey JW | title = Two structural domains of initiation factor eIF-4B are involved in binding to RNA | journal = J. Biol. Chem. | volume = 269 | issue = 20 | pages = 14465–72 | year = 1994 | doi = 10.1016/S0021-9258(17)36646-2 | pmid = 8182051 | doi-access = free }}
• {{cite journal | vauthors = Méthot N, Song MS, Sonenberg N | title = A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3 | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5328–34 | year = 1996 | pmid = 8816444 | pmc = 231531 | doi = 10.1128/MCB.16.10.5328}}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Richter NJ, Rogers GW, Hensold JO, Merrick WC | title = Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H | journal = J. Biol. Chem. | volume = 274 | issue = 50 | pages = 35415–24 | year = 1999 | pmid = 10585411 | doi = 10.1074/jbc.274.50.35415 | doi-access = free }}
• {{cite journal | vauthors = Bushell M, Wood W, Clemens MJ, Morley SJ | title = Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis | journal = Eur. J. Biochem. | volume = 267 | issue = 4 | pages = 1083–91 | year = 2000 | pmid = 10672017 | doi = 10.1046/j.1432-1327.2000.01101.x | doi-access = free }}
• {{cite journal | vauthors = Bushell M, Wood W, Carpenter G, Pain VM, Morley SJ, Clemens MJ | title = Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 23922–8 | year = 2001 | pmid = 11274152 | doi = 10.1074/jbc.M100384200 | doi-access = free }}
• {{cite journal | vauthors = Fleming K, Ghuman J, Yuan X, Simpson P, Szendröi A, Matthews S, Curry S | title = Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B | journal = Biochemistry | volume = 42 | issue = 30 | pages = 8966–75 | year = 2003 | pmid = 12885229 | doi = 10.1021/bi034506g }}
• {{cite journal | vauthors = Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW | title = Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases | journal = EMBO J. | volume = 23 | issue = 8 | pages = 1761–9 | year = 2004 | pmid = 15071500 | pmc = 394247 | doi = 10.1038/sj.emboj.7600193 }}
• {{cite journal | vauthors = Doepker RC, Hsu WL, Saffran HA, Smiley JR | title = Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H | journal = J. Virol. | volume = 78 | issue = 9 | pages = 4684–99 | year = 2004 | pmid = 15078951 | pmc = 387725 | doi = 10.1128/JVI.78.9.4684-4699.2004 }}
• {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | bibcode = 2004PNAS..10112130B | doi-access = free }}
• {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 | year = 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
• {{cite journal | vauthors = Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N | title = The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity | journal = EMBO J. | volume = 25 | issue = 12 | pages = 2781–91 | year = 2006 | pmid = 16763566 | pmc = 1500846 | doi = 10.1038/sj.emboj.7601166 }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

{{refend}}

{{PDB Gallery|geneid=1975}}

{{Initiation factors}}

{{gene-12-stub}}