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eIF5

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.{{cite journal | vauthors = Si K, Das K, Maitra U | title = Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5) | journal = J Biol Chem | volume = 271 | issue = 28 | pages = 16934–8 |date=Aug 1996 | pmid = 8663286 | doi =10.1074/jbc.271.28.16934 | doi-access = free}}{{cite web | title = Entrez Gene: EIF5 eukaryotic translation initiation factor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1983}}

EIF5 is a GTPase-activating protein.{{cite journal |vauthors=Das S, Ghosh R, Maitra U |title=Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein |journal=J. Biol. Chem. |volume=276 |issue=9 |pages=6720–6 |date=March 2001 |pmid=11092890 |doi=10.1074/jbc.M008863200 |doi-access=free }}

References

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External links

  • [http://www.nature.com/nrmicro/journal/v5/n1/box/nrmicro1558_BX1.html Cap-dependent translation initiation] from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
  • [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P55010 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)

Further reading

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  • {{cite journal | vauthors=Das S, Maiti T, Das K, Maitra U |title=Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31712–8 |year= 1998 |pmid= 9395514 |doi=10.1074/jbc.272.50.31712 |doi-access=free }}
  • {{cite journal | vauthors=Bandyopadhyay A, Maitra U |title=Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells. |journal=Nucleic Acids Res. |volume=27 |issue= 5 |pages= 1331–7 |year= 1999 |pmid= 9973622 |doi=10.1093/nar/27.5.1331 | pmc=148320 }}
  • {{cite journal | vauthors=Das S, Maitra U |title=Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3942–50 |year= 2000 |pmid= 10805737 |doi=10.1128/MCB.20.11.3942-3950.2000 | pmc=85746 }}
  • {{cite journal | vauthors=Choi SK, Olsen DS, Roll-Mecak A |title=Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2. |journal=Mol. Cell. Biol. |volume=20 |issue= 19 |pages= 7183–91 |year= 2000 |pmid= 10982835 |doi=10.1128/MCB.20.19.7183-7191.2000 | pmc=86272 |display-authors=etal}}
  • {{cite journal | vauthors=Das S, Ghosh R, Maitra U |title=Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6720–6 |year= 2001 |pmid= 11092890 |doi= 10.1074/jbc.M008863200 |doi-access= free }}
  • {{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
  • {{cite journal | vauthors=Asano K, Shalev A, Phan L |title=Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2326–37 |year= 2001 |pmid= 11331597 |doi= 10.1093/emboj/20.9.2326 | pmc=125443 |display-authors=etal}}
  • {{cite journal | vauthors=Majumdar R, Bandyopadhyay A, Deng H, Maitra U |title=Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo. |journal=Nucleic Acids Res. |volume=30 |issue= 5 |pages= 1154–62 |year= 2002 |pmid= 11861906 |doi=10.1093/nar/30.5.1154 | pmc=101238 }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Marintchev A, Kolupaeva VG, Pestova TV, Wagner G |title=Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 4 |pages= 1535–40 |year= 2003 |pmid= 12569173 |doi= 10.1073/pnas.0437845100 | pmc=149867 |bibcode=2003PNAS..100.1535M |doi-access=free }}
  • {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
  • {{cite journal | vauthors=Homma MK, Wada I, Suzuki T |title=CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 43 |pages= 15688–93 |year= 2005 |pmid= 16227438 |doi= 10.1073/pnas.0506791102 | pmc=1266118 |bibcode=2005PNAS..10215688H |display-authors=etal|doi-access=free }}
  • {{cite journal | vauthors=Conte MR, Kelly G, Babon J |title=Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. |journal=Biochemistry |volume=45 |issue= 14 |pages= 4550–8 |year= 2006 |pmid= 16584190 |doi= 10.1021/bi052387u |display-authors=etal}}
  • {{cite journal | vauthors=Bieniossek C, Schütz P, Bumann M |title=The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5. |journal=J. Mol. Biol. |volume=360 |issue= 2 |pages= 457–65 |year= 2006 |pmid= 16781736 |doi= 10.1016/j.jmb.2006.05.021 |display-authors=etal}}
  • {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal|doi-access=free }}

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{{PDB Gallery|geneid=1983}}

{{Initiation factors}}

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