Login
Login

eIF5A

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene.{{cite journal | vauthors = Steinkasserer A, Jones T, Sheer D, Koettnitz K, Hauber J, Bevec D | title = The eukaryotic cofactor for the human immunodeficiency virus type 1 (HIV-1) rev protein, eIF-5A, maps to chromosome 17p12-p13: three eIF-5A pseudogenes map to 10q23.3, 17q25, and 19q13.2 | journal = Genomics | volume = 25 | issue = 3 | pages = 749–752 | date = February 1995 | pmid = 7759117 | doi = 10.1016/0888-7543(95)80025-H }}

It is the only known protein to contain the unusual amino acid hypusine [Nε-(4-amino-2-hydroxybutyl)-lysine], which is synthesized on eIF5A at a specific lysine residue from the polyamine spermidine by two catalytic steps.{{cite journal | vauthors = Wolff EC, Kang KR, Kim YS, Park MH | title = Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification | journal = Amino Acids | volume = 33 | issue = 2 | pages = 341–350 | date = August 2007 | pmid = 17476569 | pmc = 2572820 | doi = 10.1007/s00726-007-0525-0 }}

EF-P is the bacterial homolog of eIF5A, which is modified post-translationally in a similar but distinct way.{{cite journal | vauthors = Park JH, Johansson HE, Aoki H, Huang BX, Kim HY, Ganoza MC, Park MH | title = Post-translational modification by β-lysylation is required for activity of Escherichia coli elongation factor P (EF-P) | journal = The Journal of Biological Chemistry | volume = 287 | issue = 4 | pages = 2579–2590 | date = January 2012 | pmid = 22128152 | pmc = 3268417 | doi = 10.1074/jbc.M111.309633 | doi-access = free }}{{cite journal | vauthors = Peil L, Starosta AL, Virumäe K, Atkinson GC, Tenson T, Remme J, Wilson DN | title = Lys34 of translation elongation factor EF-P is hydroxylated by YfcM | journal = Nature Chemical Biology | volume = 8 | issue = 8 | pages = 695–697 | date = August 2012 | pmid = 22706199 | doi = 10.1038/nchembio.1001 }} Both proteins are believed to catalyze peptide bond formation and help resolve ribosomal stalls, making them elongation factors despite the "initiation factor" name originally assigned.{{cite journal | vauthors = Rossi D, Kuroshu R, Zanelli CF, Valentini SR | title = eIF5A and EF-P: two unique translation factors are now traveling the same road | journal = Wiley Interdisciplinary Reviews. RNA | volume = 5 | issue = 2 | pages = 209–222 | date = 2013 | pmid = 24402910 | doi = 10.1002/wrna.1211 | s2cid = 25447826 }}

Faundes-Banka syndrome

File:Excessive length of ears; facial asymmetry (Peterson 260).jpg is seen in patients with Faundes-Banka syndrome]]

Germline deleterious heterozygous EIF5A variants cause Faundes-Banka syndrome.{{cite journal | vauthors = Faundes V, Jennings MD, Crilly S, Legraie S, Withers SE, Cuvertino S, Davies SJ, Douglas AG, Fry AE, Harrison V, Amiel J, Lehalle D, Newman WG, Newkirk P, Ranells J, Splitt M, Cross LA, Saunders CJ, Sullivan BR, Granadillo JL, Gordon CT, Kasher PR, Pavitt GD, Banka S | title = Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine | journal = Nature Communications | volume = 12 | issue = 1 | pages = 833 | date = February 2021 | pmid = 33547280 | pmc = 7864902 | doi = 10.1038/s41467-021-21053-2 | bibcode = 2021NatCo..12..833F }}{{Cite web|title=OMIM Entry - # 619376 - FAUNDES-BANKA SYNDROME; FABAS |url=https://omim.org/entry/619376 |access-date=2022-01-03 |website=omim.org}} This rare human disorder is characterized by variable combinations of developmental delay, microcephaly, micrognathia and dysmorphic features. It was named after Víctor Faundes and Siddharth Banka.

See also

EIF5A2

References

{{Reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Bevec D, Hauber J | title = Eukaryotic initiation factor 5A activity and HIV-1 Rev function | journal = Biological Signals | volume = 6 | issue = 3 | pages = 124–133 | year = 1997 | pmid = 9285095 | doi = 10.1159/000109118 }}
  • {{cite journal | vauthors = Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY | title = Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions | journal = Cell Research | volume = 15 | issue = 11–12 | pages = 923–934 | year = 2006 | pmid = 16354571 | doi = 10.1038/sj.cr.7290370 | doi-access = free }}
  • {{cite journal | vauthors = Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J | title = Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes | journal = Electrophoresis | volume = 13 | issue = 12 | pages = 960–969 | date = December 1992 | pmid = 1286667 | doi = 10.1002/elps.11501301199 | s2cid = 41855774 }}
  • {{cite journal | vauthors = Chung SI, Park MH, Folk JE, Lewis MS | title = Eukaryotic initiation factor 5A: the molecular form of the hypusine-containing protein from human erythrocytes | journal = Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | volume = 1076 | issue = 3 | pages = 448–451 | date = February 1991 | pmid = 1900436 | doi = 10.1016/0167-4838(91)90490-q }}
  • {{cite journal | vauthors = Smit-McBride Z, Dever TE, Hershey JW, Merrick WC | title = Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein | journal = The Journal of Biological Chemistry | volume = 264 | issue = 3 | pages = 1578–1583 | date = January 1989 | pmid = 2492279 | doi = 10.1016/S0021-9258(18)94226-2 | doi-access = free }}
  • {{cite journal | vauthors = Park MH, Liu TY, Neece SH, Swiggard WJ | title = Eukaryotic initiation factor 4D. Purification from human red blood cells and the sequence of amino acids around its single hypusine residue | journal = The Journal of Biological Chemistry | volume = 261 | issue = 31 | pages = 14515–14519 | date = November 1986 | pmid = 3095320 | doi = 10.1016/S0021-9258(18)66899-1 | doi-access = free }}
  • {{cite journal | vauthors = Koettnitz K, Kappel B, Baumruker T, Hauber J, Bevec D | title = The genomic structure encoding human initiation factor eIF-5A | journal = Gene | volume = 144 | issue = 2 | pages = 249–252 | date = July 1994 | pmid = 7545941 | doi = 10.1016/0378-1119(94)90385-9 }}
  • {{cite journal | vauthors = Klier H, Csonga R, Joäo HC, Eckerskorn C, Auer M, Lottspeich F, Eder J | title = Isolation and structural characterization of different isoforms of the hypusine-containing protein eIF-5A from HeLa cells | journal = Biochemistry | volume = 34 | issue = 45 | pages = 14693–14702 | date = November 1995 | pmid = 7578077 | doi = 10.1021/bi00045a010 }}
  • {{cite journal | vauthors = Koettnitz K, Wöhl T, Kappel B, Lottspeich F, Hauber J, Bevec D | title = Identification of a new member of the human eIF-5A gene family | journal = Gene | volume = 159 | issue = 2 | pages = 283–284 | date = July 1995 | pmid = 7622067 | doi = 10.1016/0378-1119(95)00136-T }}
  • {{cite journal | vauthors = Joe YA, Park MH | title = Structural features of the eIF-5A precursor required for posttranslational synthesis of deoxyhypusine | journal = The Journal of Biological Chemistry | volume = 269 | issue = 41 | pages = 25916–25921 | date = October 1994 | pmid = 7929297 | doi = 10.1016/S0021-9258(18)47333-4 | doi-access = free }}
  • {{cite journal | vauthors = Bevec D, Klier H, Holter W, Tschachler E, Valent P, Lottspeich F, Baumruker T, Hauber J | display-authors = 6 | title = Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 23 | pages = 10829–10833 | date = November 1994 | pmid = 7971969 | pmc = 45119 | doi = 10.1073/pnas.91.23.10829 | doi-access = free | bibcode = 1994PNAS...9110829B }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Ruhl M, Himmelspach M, Bahr GM, Hammerschmid F, Jaksche H, Wolff B, Aschauer H, Farrington GK, Probst H, Bevec D | display-authors = 6 | title = Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation | journal = The Journal of Cell Biology | volume = 123 | issue = 6 Pt 1 | pages = 1309–1320 | date = December 1993 | pmid = 8253832 | pmc = 2290910 | doi = 10.1083/jcb.123.6.1309 }}
  • {{cite journal | vauthors = Liu YP, Nemeroff M, Yan YP, Chen KY | title = Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification | journal = Biological Signals | volume = 6 | issue = 3 | pages = 166–174 | year = 1997 | pmid = 9285100 | doi = 10.1159/000109123 }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Singh US, Li Q, Cerione R | title = Identification of the eukaryotic initiation factor 5A as a retinoic acid-stimulated cellular binding partner for tissue transglutaminase II | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 1946–1950 | date = January 1998 | pmid = 9442029 | doi = 10.1074/jbc.273.4.1946 | doi-access = free }}
  • {{cite journal | vauthors = Schatz O, Oft M, Dascher C, Schebesta M, Rosorius O, Jaksche H, Dobrovnik M, Bevec D, Hauber J | display-authors = 6 | title = Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 4 | pages = 1607–1612 | date = February 1998 | pmid = 9465063 | pmc = 19115 | doi = 10.1073/pnas.95.4.1607 | doi-access = free | bibcode = 1998PNAS...95.1607S }}
  • {{cite journal | vauthors = Lee YB, Joe YA, Wolff EC, Dimitriadis EK, Park MH | title = Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor | journal = The Biochemical Journal | volume = 340 | issue = 1 | pages = 273–281 | date = May 1999 | pmid = 10229683 | pmc = 1220246 | doi = 10.1042/0264-6021:3400273 }}

{{refend}}

{{Initiation factors}}

{{gene-17-stub}}

Category:Rare diseases